US5709934A
Expired / Lapsed
US
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Bipolymer foams having extracellular matrix particulates
Assignee: Medtronic International Ltd Hong Kong
•
Filing: 1994-11-22
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Granted: 1998-01-20
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Expires: 2014-11-22
Abstract
Abstract A biopolymer solution is polymerized to form a gel which is freeze-dried and crosslinked with ultraviolet radiation to form a biopolymer foam. The foam is filled with a collagen solution and the combination is freeze-dried or the foam is filled with a collagen solution containing extracellular matrix particulates and that combination is freeze-dried, thereby forming a foam to which extracellular matrix particulates are attached.
Inventors
- 👤 Eugene Bell
- 👤 Timothy W. Fofonoff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:41
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/425; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/40; A61L27/44; A61L27/46; A61L27/48; A61L27/50; A61L27/56; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61L31/14; A61L31/146; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; C12; C12N; C12N5/00; C12N5/0068; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; C12N2533/00; C12N2533/50; C12N2533/54; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249954; Y10T428/25
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
20 words
A sponge, comprising: a biopolymer foam comprising a biopolymer matrix having interstices surrounded by biocompatible biopolymer; and extracellular matrix particulates.
Claim 2
Dependent Claim
20 words
A sponge, comprising: a biopolymer foam comprising a biopolymer matrix having interstices surrounded by biocompatible biopolymer; and extracellular matrix particulates.
Claim 3
Dependent Claim
24 words
The sponge of claim 1, wherein the biopolymer is selected from the group consisting of collagen, alginic acid, polyvinyl alcohol, laminin, fibrinogen, and fibronectin.
Claim 4
Dependent Claim
17 words
The sponge of claim 1, wherein the biopolymer comprises a mixture of at least two different biopolymers.
Claim 5
Dependent Claim
10 words
The sponge of claim 2, wherein the biopolymer is collagen.
Claim 6
Dependent Claim
11 words
The sponge of claim 4, wherein the collagen is porcine collagen.
Claim 7
Dependent Claim
12 words
The sponge of claim 5, wherein the collagen is fetal porcine collagen.
Claim 8
Dependent Claim
11 words
The sponge of claim 4, wherein the collagen includes crosslinked collagen.
Claim 9
Dependent Claim
11 words
The sponge of claim 4, wherein the collagen includes uncrosslinked collagen.
Claim 10
Dependent Claim
15 words
The sponge of claim 1, wherein the extracellular matrix particulates are dispersed throughout the foam.
Claim 11
Dependent Claim
19 words
The sponge of claim 9, wherein the extracellular matrix particulates are dispersed in a biopolymer solution filling the foam.
Claim 12
Dependent Claim
25 words
The sponge of claim 1, wherein a suspension of extracellular matrix particulates in a collagen solution is coated on the surface of the biopolymer foam.
Claim 13
Dependent Claim
13 words
The sponge of claim 11, wherein the biopolymer foam and suspension are freeze-dried.
Claim 14
Dependent Claim
15 words
A vascular prosthesis comprising the sponge of claim 1 in the form of a tube.
Claim 15
Dependent Claim
28 words
The vascular prosthesis of claim 13, wherein the tube is seeded internally with smooth muscle cells, externally with adventitial fibroblasts, and on its luminal surface with endothelial cells.
Claim 16
Dependent Claim
17 words
A glandular implant comprising the sponge of claim 1, wherein the foam is seeded with glandular cells.
Claim 17
Dependent Claim
15 words
The glandular implant of claim 15, wherein the glandular cells are derived from the pancreas.
Claim 18
Dependent Claim
22 words
A periodontal prosthesis comprising the sponge of claim 1, wherein the biopolymer foam or the sponge is seeded with periodontal ligament cells.
Claim 19
Dependent Claim
9 words
A skin prosthesis comprising the sponge of claim 1.
Claim 20
Dependent Claim
27 words
A sponge, comprising: a biopolymer foam comprising a biopolymer matrix having interstices surrounded by biocompatible biopolymer wherein the interstices are occupied by cells; and extracellular matrix particulates.
Claim 21
Dependent Claim
27 words
A sponge, comprising: a biopolymer foam comprising a biopolymer matrix having interstices surrounded by biocompatible biopolymer wherein the interstices are occupied by cells; and extracellular matrix particulates.
Claim 22
Dependent Claim
14 words
The sponge of claim 1 further comprising cells occupying the interstices of the foam.
Claim 23
Dependent Claim
10 words
The sponge of claim 10, wherein the biopolymer is collagen.
Claim 24
Dependent Claim
13 words
The sponge of claim 1, wherein the biopolymer is derived from a pig.
Claim 25
Dependent Claim
14 words
The sponge of claim 22, wherein the biopolymer is derived from a fetal pig.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-19 | 2001-07-21 | 2002-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-19 | 2005-07-21 | 2006-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-19 | 2009-07-21 | 2010-01-20 | $7700.00 | Window Closed / Lapsed |