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EP0562864A1
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Heteromorphic sponges containing active agents
Assignee: Ethicon Inc
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Filing: 1993-03-25
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Granted: —
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Expires: 2013-03-25
Abstract
Abstract The invention provides wound dressing and/or implant materials comprising a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein both the matrix structure and the substructure are formed from bioabsorbable biopolymer materials. The substructure may, for example, comprise biopolymer films, flakes, fibres or microspheres embedded in the matrix structure of sponge. The pharmacologically active agent may comprise antiseptics, antibiotics, analgesics. One or more such active agents may be incorporated separately into the matrix and/or the substructure so as to achieve controlled or phasic release of the active agents into the wound.
Inventors
- 👤 Arthur L. Rosenthal
- 👤 Nicholas D. Light
- 👤 Carla A. Haynes
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 04:52
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/009; A61L15/00; A61L15/16; A61L15/22; A61L15/28; A61L15/32; A61L15/325; A61L15/42; A61L15/425; A61L15/44; A61L15/64; A61L26/0066; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/412; A61L2300/414; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
38 words
A bioabsorbable heteromorphic sponge comprising: a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein the matrix structure and the said at least one substructure are formed of bioabsorbable biopolymer materials.
Claim 2
Dependent Claim
39 words
A bioabsorbable heteromorphic sponge according to claim 1 wherein the said at least one substructure is selected from the group consisting of milled freeze-dried sponges, powders, films, flaked or broken films, aggregates, microspheres, fibres, fibre bundles and mixtures thereof.
Claim 3
Dependent Claim
47 words
A bioabsorbable heteromorphic sponge according to claim 1 or 2 wherein the bioabsorbable biopolymer materials comprise macromolecules selected from the group consisting of all collagen types, elastin, fibronectin, vitronectin, laminin, tenascin, hyaluronic acid, chondroitin sulphate, dermatan sulphate, heparan sulphate, fibrin, oxidised regenerated cellulose, dextran and mixtures thereof.
Claim 4
Dependent Claim
33 words
A bioabsorbable heteromorphic sponge according to any preceding claim wherein the said at least one pharmacologically active agent is incorporated separately into the matrix structure or into the said at least one substructure.
Claim 5
Dependent Claim
45 words
A bioabsorbable heteromorphic sponge according to any preceding claim comprising a first pharmacologically active agent incorporated separately in the matrix structure of sponge and a second pharmacologically active agent different from said first pharmacologically active agent incorporated separately in the said at least one substructure.
Claim 6
Dependent Claim
49 words
A bioabsorbable heteromorphic sponge according to any preceding claim wherein the said at least one pharmacologically active agent is selected from the group consisting of antimicrobials, cytokines, growth factors, growth factor antagonists, antibodies, peptides, angiogenic factors, hormones, enzymes, metabolic or breakdown products of biopolymers, pain killers and mixtures thereof.
Claim 7
Independent Claim
75 words
A method of making a bioabsorbable heteromorphic sponge comprising: providing a first biopolymer component and at least one second biopolymer component; adding a pharmacologically active agent to the first biopolymer component or to the second biopolymer component; adding the second biopolymer component to the first biopolymer component; forming a heterogeneous premix comprising the first biopolymer component and the second biopolymer component dispersed in a liquid; and freeze-drying the heterogeneous premix to form the heteromorphic sponge.
Claim 8
Dependent Claim
39 words
A method according to claim 7 wherein the said at least one second biopolymer component is selected from the group consisting of milled free-dried sponges, powders, films, flaked or broken films, aggregates, microspheres, fibres, fibre bundles and mixtures thereof.
Claim 9
Dependent Claim
54 words
A method according to claim 7 or 8 wherein the first biopolymer component and the said at least one second biopolymer component comprise biopolymers selected from the group consisting of all collagen types, elastin, fibronectin, vitronectin, laminin, tenascin, hyaluronic acid, chondroitin sulphate, dermatan sulphate, heparan sulphate, fibrin, oxidised regenerated cellulose, dextran and mixtures thereof.
Claim 10
Dependent Claim
45 words
A method according to claim 7, 8 or 9 wherein the pharmacologically active agent is selected from the group consisting of antimicrobials, cytokines, growth factors, growth factor antagonists, antibodies, peptides, angiogenic factors, hormones, enzymes, metabolic or breakdown products of biopolymers, pain killers and mixtures thereof.
Claim 11
Independent Claim
15 words
A method according to any of claims 7 to 10 wherein the liquid comprises water.
Claim 12
Independent Claim
21 words
A method according to any of claims 7 to 11 wherein the heterogeneous premix is a gel, paste, slurry or emulsion.
Claim 13
Independent Claim
34 words
A method according to any of claims 7 to 12 wherein the heterogeneous premix further contains dissolved acid in an amount sufficient to provide a pH of the heterogeneous premix between 2 and 6.
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