US4891359A
Expired / Lapsed
US
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Hemostatic collagen paste composition
Assignee: Ethicon Inc
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Filing: 1988-12-08
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Granted: 1990-01-02
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Expires: 2008-12-08
Abstract
Abstract A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 2 to 30% of crosslinked collagen powder of 10 to 100 mesh particle size and 30 to 98% of water or an aqueous saline solution and hemostatic paste compositions that also comprise a hemostatic enhancing amount of thrombin, as well as methods of making and using such hemostatic collagen paste compositions.
Inventors
- 👤 Lowell Saferstein
- 👤 Stephen J. Wolf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:08
CPC Classifications
A; A61; A61L; A61L26/00; A61L26/0061; A61L26/0066; A61L24/00; A61L24/001; A61L24/0015; A61L26/0009; A61L26/0028; A61L26/0033; A61P; A61P7/00; A61P7/04; A61L2300/00; A61L2300/40; A61L2300/418; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
43 words
A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 5 to 30% of a water insoluble crosslinked collagen powder of 10 to 100 mesh particle size and 70 to 95% of water or an aqueous saline solution.
Claim 2
Dependent Claim
43 words
A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 5 to 30% of a water insoluble crosslinked collagen powder of 10 to 100 mesh particle size and 70 to 95% of water or an aqueous saline solution.
Claim 3
Dependent Claim
41 words
The collagen paste composition of claim 1 wherein the composition comprises about 5 to 30% crosslinked collagen powder of 20 to 60 particle mesh size and about 70 to 95% water or aqueous saline solution by weight of the total compositions.
Claim 4
Dependent Claim
20 words
The collagen paste composition of claim 1 wherein the aqueous saline solution has a saline concentration of 0.1 to 2.7%.
Claim 5
Dependent Claim
19 words
The collagen Paste composition of claim 1 wherein the aqueous saline solution has a saline concentration of about 0.9.
Claim 6
Dependent Claim
18 words
The collagen paste composition of claim 2 wherein the powder is of 40 to 60 Particle mesh size.
Claim 7
Dependent Claim
29 words
The collagen Paste composition of claim 2 wherein the composition comprises about 12% crosslinked collagen powder and about 88% water or saline solution by weight of the total composition.
Claim 8
Dependent Claim
19 words
A collagen paste composition product comprising the composition of claim 3 packed in a squeeze tube or syringe package.
Claim 9
Dependent Claim
48 words
A collagen paste hemostatic product comprising a mixture, by weight of the total composition, of 5 to 30% of a water insoluble crosslinked collagen powder of 40 to 60 mesh particles size and 70 to 95% of an aqueous glycerine solution containing a hemostatic enhancing amount of thrombin.
Claim 10
Dependent Claim
48 words
A collagen paste hemostatic product comprising a mixture, by weight of the total composition, of 5 to 30% of a water insoluble crosslinked collagen powder of 40 to 60 mesh particles size and 70 to 95% of an aqueous glycerine solution containing a hemostatic enhancing amount of thrombin.
Claim 11
Dependent Claim
31 words
A mammalian hemostatic method for treating a bleeding wound comprising applying the collagen paste product of claim 1 to a wound to make intimate contact with bleeding capillaries in the wound.
Claim 12
Dependent Claim
30 words
A mammalian method for treating a bleeding wound comprising applying the collagen paste product of claim 2 to a wound to make intimate contact with bleeding capillaries in the wound.
Claim 13
Independent Claim
62 words
A method of making a hemostatic collagen paste composition comprising the steps of: grinding a water insoluble crosslinked collagen sponge material to prepare water insoluble crosslinked collagen powder to 10 to 100 mesh; and admicing from 5 to 30% of the crosslinked collagen powder with from 70 to 95% water or an aqueous saline solution to produce a collagen paste composition therefrom.
Claim 14
Independent Claim
62 words
A method of making a hemostatic collagen paste composition comprising the steps of: grinding a water insoluble crosslinked collagen sponge material to prepare water insoluble crosslinked collagen powder to 10 to 100 mesh; and admicing from 5 to 30% of the crosslinked collagen powder with from 70 to 95% water or an aqueous saline solution to produce a collagen paste composition therefrom.
Claim 15
Dependent Claim
19 words
The method of claim 11 wherein a hemostatic enhancing effective amount of thrombin is added to the collagen paste.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-01 | 1993-07-03 | 1994-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-01 | 1997-07-03 | 1998-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-01 | 2001-07-03 | 2002-01-02 | $7700.00 | Window Closed / Lapsed |