US5171273A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic collagen orthopaedic structures such as grafts, tendons and other structures
Assignee: Rutgers Health
•
Filing: 1989-01-13
•
Granted: 1992-12-15
•
Expires: 2009-01-13
Abstract
Abstract The invention provides graft, prothesis, orthopaedic structures, implants and like body replacement parts which are constituted of synthetic collagen fibers, an embodiment of which is a tendon or a ligament prosthesis, graft or implants. These body parts have a combination of very useful properties, particularly high tensile strength combined with biocompatability.
Inventors
- 👤 Frederick H. Silver
- 👤 Yasushi P. Kato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 16:24
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/40; A61L27/44; A61L27/48; A61F; A61F2/00; A61F2/02; A61F2/08; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/10
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
41 words
A biocompatible, biodegradable graft which is a tendon of improved mechanical properties which comprises aligned cross-linked synthetic collagen fibers embedded in a non-crosslinked and loose collagen matrix, said fibers having a diameter in the range of 20 to about 60 microns.
Claim 2
Dependent Claim
41 words
A biocompatible, biodegradable graft which is a tendon of improved mechanical properties which comprises aligned cross-linked synthetic collagen fibers embedded in a non-crosslinked and loose collagen matrix, said fibers having a diameter in the range of 20 to about 60 microns.
Claim 3
Dependent Claim
22 words
The biocompatible, biodegradable graft of claim 1, wherein said fibers have a diameter in the range of 20 to about 60 microns.
Claim 4
Dependent Claim
10 words
The biocompatible, biodegradable graft of claim 2 which is elastic.
Claim 5
Dependent Claim
15 words
The biocompatible, biodegradable graft of claim 3 which maintains elongation of 15 percent to failure.
Claim 6
Dependent Claim
37 words
The biocompatible, biodegradable graft of claim 3 of improved ultimate tensile strength (UTS) which comprises proteoglycans wherein the protoglycans have an average molecular weight of at least 500,000, wherein the protoglycans are incorporated into the interfibrillar spaces.
Claim 7
Dependent Claim
20 words
The biocompatible, biodegradable graft of claim 5 wherein the content of proteoglycans does not exceed about one percent by weight.
Claim 8
Dependent Claim
23 words
The biocompatible, biodegradable graft of claim 6 wherein the proteoglycans have a molecular weight in the range of about 1,000,000 to about 3,000,000.
Claim 9
Dependent Claim
16 words
The biocompatible, biodegradable graft of claim 7 which has an UTS in excess of 30 MPA.
Claim 10
Dependent Claim
21 words
The biocompatible, biodegradable graft of claim 8 which has an UTS in the range of about 30 to about 130 MPA.
Claim 11
Dependent Claim
21 words
The biocompatible, biodegradable graft of claim 9 which has an UTS in the range of about 70 to about 120 MPA.
Claim 12
Dependent Claim
32 words
The biocompatible, biodegradable graft of claim 8 which has a wet ultimate strain in the range of about 17.50±4.40, 14.70±2.10 and 17.70±2.20 at strain rates of 10, 50 and 100 percent, respectively.
Claim 13
Dependent Claim
32 words
The biocompatible, biodegradable graft of claim 9 which has wet low strain modules in the range of about 179.5±54.7, 198.1±56.7 and 170.1±32.9 at strain rates of 10, 50 and 100 percent, respectively.
Claim 14
Dependent Claim
40 words
The biocompatible, biodegradable graft of claim 8 which has a wet ultimate strain in the range of about 16.10±2.70, 13.0±2.90 and 14.50±3.50 at strain rates of 10, 50 and 100 percent, respectively, wherein the fibres were 2 days cross-linked fibers.
Claim 15
Dependent Claim
40 words
The biocompatible, biodegradable graft of claim 8 which has wet low strain modules in the range of about 407.0±96.6, 503.0±127.7 and 412.0±83.4 at strain rates of 10, 50 and 100 percent, respectively, wherein the fibers were 2 days cross-linked fibers.
Claim 16
Dependent Claim
30 words
The biocompatible, biodegradable graft of claim 8 which has an UTS in the range of about 27.4±5.60, 23.9±3.80 and 31.3±4.70 at strain rates of 10, 50 and 100 percent, respectively.
Claim 17
Dependent Claim
35 words
The biocompatible, biodegradable graft of claim 8 which has an UTS in the range of about 66.2±17.20, 59.2±17.30 and 50.0±17.40 at strain rates of 10, 50 and 100 percent, respectively, with 2 days cross-linked fibers.
Claim 18
Dependent Claim
35 words
The biocompatible, biodegradable graft of claim 10 wherein the graft is selected from the group consisting of a sheet, a tube, a mesh, a film, a filament, a fiber and a woven or non-woven sheet.
Claim 19
Dependent Claim
26 words
The biocompatible, biodegradable graft of claim 10 which has an UTS which is in excess of an autograph or of naturally occurring tendon fibers of rats.
References Cited (Backward Citations)
US3551560A
Cited
US4420339A
Cited
US4544516A
Cited
US4801299A
Cited
US4629458A
Cited
US4642117A
Cited
US4911710A
Cited
US4772288A
Cited
US4846835A
Cited
US4880429A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-15 | 1996-06-15 | 1996-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-15 | 2000-06-15 | 2000-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-15 | 2004-06-15 | 2004-12-15 | $7700.00 | Window Closed / Lapsed |