Patent US5110604A successfully refreshed from Google Patents.
US5110604A
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Processes for producing collagen matrixes and methods of using same
Assignee: Surgical Specialties US Corp
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Filing: 1990-12-19
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Granted: 1992-05-05
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Expires: 2010-12-19
Abstract
Abstract Collagen implants that are useful as wound healing matrices are characterized by being formed of collagen fibrils that are not chemically cross-linked, and having a bulk density of 0.01 to 0.3 g/cm 3 and a pore population in which at least about 80% of the pores have an average pore size of 35 to 250 microns. The implants are capable of promoting connective tissue deposition, angiogenesis, reepithelialization, and fibroplasia. The wound healing matrix also serves as an effective sustained delivery system for bioactive agents.
Inventors
- 👤 George H. Chu
- 👤 Yasushi Ogawa
- 👤 John M. McPherson
- 👤 George Ksander
- 👤 Bruce Pratt
- 👤 Diana Hendricks
- 👤 Hugh McMullin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:17
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L27/50; A61L27/54; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/426; Y; Y10; Y10S; Y10S128/00; Y10S128/08; Y10S623/00; Y10S623/915
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
75 words
A method for promoting wound healing in a mammal having a wound, which method comprises: applying to said wound a matrix having a density of about 0.01 to about 0.3 g/cm 3 , a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprises fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked.
Claim 2
Independent Claim
75 words
A method for promoting wound healing in a mammal having a wound, which method comprises: applying to said wound a matrix having a density of about 0.01 to about 0.3 g/cm 3 , a thickness of about 1-20 mm, and having pores at least 80% of which are at least 35 um in diameter, wherein said matrix comprises fibrillar atelopeptide collagen, wherein said fibrils are about 50-200 nm in diameter, and are not chemically cross-linked.
Claim 3
Dependent Claim
19 words
The method of claim 1, wherein said matrix further comprises a biological growth factor in a wound-healing effective amount.
Claim 4
Dependent Claim
38 words
The method of claim 2 wherein said growth factor comprises TGF-beta1, TGF-beta2, PDGF-AA, PDGF-AB, PDGF-BB, EGF, acidic FGF, basic FGF, TGF-alpha, connective tissue activating peptides, beta-thromboglobulin, insulin-like growth factors, tumor necrosis factors, interleukins, nerve growth factor, or interferons.
Claim 5
Dependent Claim
15 words
The method as claimed in claim 2, wherein the biological growth factor is a TGF-beta.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-05-05 | 1995-11-04 | 1996-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-05-05 | 1999-11-04 | 2000-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-05-05 | 2003-11-04 | 2004-05-05 | $7700.00 | Window Closed / Lapsed |