Patent US5092841A successfully refreshed from Google Patents.
US5092841A
Expired / Lapsed
US
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Method for treating an arterial wall injured during angioplasty
Assignee: Wayne State University
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Filing: 1990-05-17
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Granted: 1992-03-03
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Expires: 2010-05-17
Abstract
Abstract A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been mechanically injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and small vessels of the arterial wall during apposition of the angioplasty catheter to the arterial wall; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures, thereby coating the luminal surface of the arterial wall with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Inventors
- 👤 James R. Spears
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:14
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/22; A61B17/00491; A61B17/22004; A61B18/00; A61B18/04; A61B18/08; A61B18/082; A61B18/18; A61B18/20; A61B18/22; A61B18/28; A61B2017/00831; A61B2017/22001; A61B2017/22002; A61B2017/22038; A61B2017/22051; A61B2017/22062; A61B2017/22064; A61B2017/22082; A61B2017/22084; A61B2017/22085; A61B2017/22087; A61M; A61M25/00; A61M25/10; A61M2025/1043; A61M2025/105; A61M25/104; A61M37/00; A61M37/0092
Claims Analysis
Total Claims: 65
Claim 1
Independent Claim
171 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 2
Independent Claim
171 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 3
Independent Claim
13 words
The method of claim wherein the angioplasty catheter utilized includes an inflatable balloon.
Claim 4
Dependent Claim
39 words
The method of claim 2 wherein the inflatable balloon is at least partially inflated before delivering the bioprotective material between the arterial wall and the inflatable balloon so that the layer of the bioprotective material may be formed therebetween.
Claim 5
Dependent Claim
37 words
The method of claim 1 wherein the bioprotective material utilized is macroaggregated albumin which bonds to the luminal surface and within fissures and vessels of the aterial wall as a result of the application of thermal energy.
Claim 6
Dependent Claim
55 words
The method of claim 1 wherein the bioprotective material utilized comprises platelets, injected as a suspension, which upon being trapped between the inflatable balloon and the luminal surface become adherent to the luminal surface and to tissues adjacent to fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 7
Dependent Claim
56 words
The method of claim 1 wherein the bioprotective material comprises red blood cells, injected as a suspension, which upon being trapped between the inflatable balloon and the luminal surface become adherent to the luminal surface and to tissues adjacent to fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 8
Dependent Claim
54 words
The method of claim 1 wherein the bioprotective material comprises liposomes, injected as a suspension, which upon being trapped between the inflatable balloon and the luminal surface become adherent to the luminal surface and to tissues adjacent to fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 9
Dependent Claim
47 words
The method of claim 1 wherein the bioprotective material utilized is gelatin which upon being trapped between the inflatable balloon and the luminal surface bonds to the luminal surface and within fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 10
Dependent Claim
50 words
The method of claim 1 wherein the bioprotective material utilized is a solution of fibrinogen which upon being trapped between the inflatable balloon and the luminal surface precipitates onto the luminal surface and within fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 11
Dependent Claim
50 words
The method of claim 1 wherein the bioprotective material utilized is a solution of collagen which upon being trapped between the inflatable balloon and the luminal surface precipitates onto the luminal surface and within fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 12
Dependent Claim
53 words
The method of claim 1 wherein the bioprotective material utilized is a solution of a high molecular carbohydrate which upon being trapped between the inflatable balloon and the luminal surface precipitates onto the luminal surface and within fissures and vessels of the arterial wall as a result of the application of thermal energy.
Claim 13
Dependent Claim
35 words
The method of claim 1 wherein the bioprotective material utilized entraps a useful pharmaceutical agent in order to provide local drug therapy directly to the luminal surface, and to deeper layers of the arterial wall.
Claim 14
Dependent Claim
13 words
The method of claim 12 wherein the useful pharmaceutical agent is an anti-coagulant.
Claim 15
Dependent Claim
14 words
The method of claim 12 wherein the useful pharmaceutical agent is a fibrinolytic agent.
Claim 16
Dependent Claim
14 words
The method of claim 12 wherein the useful pharmaceutical agent is a thrombolytic agent.
Claim 17
Dependent Claim
14 words
The method of claim 12 wherein the useful pharmaceutical agent is an anti-inflammatory agent.
Claim 18
Dependent Claim
13 words
The method of claim 12 wherein the useful pharmaceutical is an anti-proliferative compound.
Claim 19
Dependent Claim
12 words
The method of claim 12 wherein the useful pharmaceutical is an immunosuppressant.
Claim 20
Dependent Claim
13 words
The method of claim 12 wherein the useful pharmaceutical is a collagen inhibitor.
Claim 21
Dependent Claim
15 words
The method of claim 12 wherein the useful pharmaceutical is an endothelial cell growth promotor.
Claim 22
Dependent Claim
13 words
The method of claim 12 wherein the useful pharmaceutical is a sulfated polysaccharide.
Claim 23
Dependent Claim
36 words
The method of claim 1 wherein the bioprotective material includes a drug which is bound to albumin in solution prior to injection so that the drug is permanently affixed thereto by application of the thermal energy.
Claim 24
Dependent Claim
32 words
The method of claim 1 wherein the bioprotective material includes a drug which is physically trapped within a precipitated layer of albumin after the drug is injected with a solution of albumin.
Claim 25
Dependent Claim
11 words
The method of claim 1 wherein the bioprotective material comprises microspheres.
Claim 26
Dependent Claim
17 words
The method of claim 1 wherein the bioprotective material includes a drug preparation having an encapsulating medium.
Claim 27
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises albumin.
Claim 28
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises carbohydrates.
Claim 29
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises platelets.
Claim 30
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises liposomes.
Claim 31
Dependent Claim
13 words
The method of claim 25 wherein the encapsulating medium comprises red blood cells.
Claim 32
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises gelatin.
Claim 33
Dependent Claim
11 words
The method of claim 25 wherein the encapsulating medium comprises fibrin.
Claim 34
Dependent Claim
13 words
The method of claim 25 wherein the encapsulating medium comprises a synthetic polymer.
Claim 35
Dependent Claim
13 words
The method of claim 25 wherein the encapsulating medium comprises a sulfated polysaccharide.
Claim 36
Dependent Claim
13 words
The method of claim 25 wherein the encapsulating medium comprises an inorganic salt.
Claim 37
Dependent Claim
13 words
The method of claim 25 wherein the encapsulating medium comprises a phosphate glass.
Claim 38
Dependent Claim
18 words
The method of claim 1 wherein the bioprotective material is a suspension of microspheres in a physiologic solution.
Claim 39
Dependent Claim
49 words
The method of claim 1 wherein the step of removing the angioplasty catheter is followed by the step of bonding the bioprotective material to the lesion so that the bioprotective material remains adherent to the arterial wall, and fills cracks and recesses therewithin, thereby providing a smooth, luminal surface.
Claim 40
Dependent Claim
64 words
The method of claim 1 wherein the bioprotective material is delivered from a sleeve thereof provided upon the angioplasty catheter, the sleeve being disposed adjacent the arterial wall during apposition of the angioplastic catheter thereto, so that the sleeve of bioprotective material is transferred therefrom to the luminal surface, thereby becoming persistently affixed thereto upon applying the thermal energy and removing the angioplasty catheter.
Claim 41
Dependent Claim
32 words
The method of claim 1 wherein microspheres are formed in situ at the luminal surface and within the arterial wall as a result of the thermal energy applied to the bioprotective material.
Claim 42
Dependent Claim
18 words
The method of claim 1 wherein a drug, simultaneously injected with the bioprotective material, is entrapped within microspheres.
Claim 43
Dependent Claim
25 words
The method of claim 1 wherein the bioprotective material functions as a physiologic glue, thereby enhancing thermal fusion of fissured tissues within the arterial wall.
Claim 44
Dependent Claim
18 words
The method of claim 1 wherein the bioprotective material includes a chromophore which enhances absorption of electromagnetic radiation.
Claim 45
Dependent Claim
15 words
The method of claim 1 wherein a photosensitive dye is entrapped within the bioprotective material.
Claim 46
Dependent Claim
18 words
The method of claim 25 wherein the encapsulating medium comprises a chromophore which enhances absorption of electromagnetic radiation.
Claim 47
Dependent Claim
13 words
The method of claim 45 wherein the encapsulating medium entraps a photosensitive dye.
Claim 48
Dependent Claim
13 words
The method of claim 1 wherein the angioplasty catheter is a metal probe.
Claim 49
Dependent Claim
13 words
The method of claim 1 wherein the applied thermal energy is electromagnetic radiation.
Claim 50
Dependent Claim
15 words
The method of claim 48 wherein the applied thermal energy is continuous wave electromagnetic radiation.
Claim 51
Dependent Claim
14 words
The method of claim 48 wherein the applied thermal energy is pulsed electromagnetic radiation.
Claim 52
Dependent Claim
12 words
The method of claim 48 wherein the electromagnetic radiation is laser radiation.
Claim 53
Dependent Claim
12 words
The method of claim 48 wherein the electromagnetic radiation is radio-frequency radiation.
Claim 54
Dependent Claim
12 words
The method of claim 48 wherein the electromagnetic radiation is microwave radiation.
Claim 55
Dependent Claim
14 words
The method of claim 48 wherein the electromagnetic radiation is generated from electrical resistance.
Claim 56
Dependent Claim
27 words
The method of claim 1 wherein the bioprotective material is injected into the artery through the angioplasty catheter which is placed proximal to the lesion being treated.
Claim 57
Dependent Claim
32 words
The method of claim 2 wherein the bioprotective material is injected through a channel within the angioplasty catheter to the arterial wall by exiting through ports located proximal to the inflatable balloon.
Claim 58
Dependent Claim
27 words
The method of claim 2 wherein the bioprotective material is injected through the angioplasty catheter to the arterial wall through microscopic perforations provided within the inflatable balloon.
Claim 59
Independent Claim
171 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 60
Independent Claim
171 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall having been injured during an angioplasty procedure, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 61
Independent Claim
163 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: performing angioplasty; positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 62
Independent Claim
163 words
A method for treating a lesion in an arterial wall having plaque thereon and a luminal surface, the arterial wall and the plaque including fissures resulting therefrom, the method comprising the steps of: performing angioplasty; positioning an angioplasty catheter adjacent to the lesion being treated; delivering a bioprotective material between the arterial wall and the angioplasty catheter so that the bioprotective material is entrapped therebetween and permeates into the fissures and vessels of the arterial wall during apposition of the angioplasty catheter thereto; applying thermal energy to the lesion, thereby bonding the bioprotective material to the arterial wall and within the fissures and vessels of the arterial wall; and removing the angioplasty catheter, the bioprotective material remaining adherent to the arterial wall and within the fissures and vessels thereof, thereby coating the luminal surface with an insoluble layer of the bioprotective material so that the insoluble layer provides at least semi-permanent protection to the arterial wall, despite contact with blood flowing adjacent thereto.
Claim 63
Dependent Claim
26 words
The method of claim 1 wherein the step of applying thermal energy to the lesion comprises applying the thermal energy from the angioplasty catheter radially outwardly.
Claim 64
Dependent Claim
31 words
The method of claim 1 wherein the step of applying thermal energy to the lesion comprises delivering the thermal energy from a source thereof disposed outside the arterial wall radially inwardly.
Claim 65
Dependent Claim
37 words
The method of claim 1 wherein the step of applying thermal energy to the lesion comprises the step of applying thermal energy so that the temperature within the bioprotective material is raised to at least 50° C.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-03-03 | 1995-09-02 | 1996-03-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-03 | 1999-09-02 | 2000-03-03 | $3760.00 | Window Closed / Lapsed |
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