Patent US4170895A successfully refreshed from Google Patents.
Patent US4895566A successfully refreshed from Google Patents.
US4895566A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coating medical devices with cationic antibiotics
Assignee: CR Bard Inc
•
Filing: 1988-06-15
•
Granted: 1990-01-23
•
Expires: 2008-06-15
Abstract
Abstract A medical device having long-lasting bactericidal properties and a method for making the same is provided. The material from which the medical device is made, the substrate, carries a negatively-charged group having a pKa of less than 6. A cationic antibiotic is ionically bonded to the negatively-charged group. The negatively-charged group may be a portion of a larger carrier molecule. The carrier molecule is bound to the substrate such that the negatively-charged group is exposed for ionic interaction with the cationic antibiotic. Heparin is an ideal carrier molecule because it has both anti-bacterial adhesion activity and anti-thrombogenic activity.
Inventors
- 👤 Clarence C. Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:20
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61P; A61P31/00; A61P31/04; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/45; A61L2300/80; A61L2300/802
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
59 words
A medical device having long-lasting bactericidal properties comprising, a substrate, heparin molecules ionically bound to said substrate via anchor molecules, said anchor molecules attached directly to said substrate and interposed between said heparin molecules and said substrate, said anchor molecules selected from the group consisting of BZK and TDMAC, and cationic antibiotic molecules ionically bound to said heparin molecules.
Claim 2
Dependent Claim
59 words
A medical device having long-lasting bactericidal properties comprising, a substrate, heparin molecules ionically bound to said substrate via anchor molecules, said anchor molecules attached directly to said substrate and interposed between said heparin molecules and said substrate, said anchor molecules selected from the group consisting of BZK and TDMAC, and cationic antibiotic molecules ionically bound to said heparin molecules.
Claim 3
Dependent Claim
22 words
A medical device as claimed in claim 1 wherein more than one cationic antibiotic molecule is bound to each molecule of heparin.
Claim 4
Dependent Claim
19 words
A medical device as claimed in claim 1 wherein said cationic antibiotic is an aminoglycoside or a polypeptide antibiotic.
Claim 5
Dependent Claim
23 words
A medical device as claimed in claim 1 wherein said cationic antibiotic is selected from the group consisting of Polymyxin B and Gentamicin.
Claim 6
Dependent Claim
100 words
In a medical device prepared from a substrate, a method of imparting said medical device with long-lasting bactericidal properties comprising, attaching anchor molecules selected from the group consisting of BZK and TDMAC directly to said substrate by soaking said substrate in a solution containing said anchor molecules, next soaking said substrate in a solution containing heparin molecules in monovalent metal salt form to ionically bind said heparin molecules to said anchor molecules on said substrate, and then soaking said substrate in a solution containing a salt form of cationic antibiotic molecules to bind said cationic antibiotic molecules to said heparin.
Claim 7
Dependent Claim
100 words
In a medical device prepared from a substrate, a method of imparting said medical device with long-lasting bactericidal properties comprising, attaching anchor molecules selected from the group consisting of BZK and TDMAC directly to said substrate by soaking said substrate in a solution containing said anchor molecules, next soaking said substrate in a solution containing heparin molecules in monovalent metal salt form to ionically bind said heparin molecules to said anchor molecules on said substrate, and then soaking said substrate in a solution containing a salt form of cationic antibiotic molecules to bind said cationic antibiotic molecules to said heparin.
Claim 8
Dependent Claim
22 words
A method as claimed in claim 5 further characterized by binding more than one cationic antibiotic molecule to each molecule of heparin.
References Cited (Backward Citations)
US3896813A
Cited
US3677800A
Cited
US3987797A
Cited
US4265927A
Cited
US4265928A
Cited
US4326532A
Cited
US4539234A
Cited
US4442133A
Cited
US4678660A
Cited
US4713402A
Cited
US4749585A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-22 | 1993-07-24 | 1994-01-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-22 | 1997-07-24 | 1998-01-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-22 | 2001-07-24 | 2002-01-23 | $7700.00 | Window Closed / Lapsed |