Patent US4874614A successfully refreshed from Google Patents.
US4874614A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical tableting method
Assignee: Abbott Laboratories
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Filing: 1989-01-30
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Granted: 1989-10-17
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Expires: 2009-01-30
Abstract
Abstract A method of preventing the fracture of coated drug granules during the compression of the granules into a commercially acceptable tablet matrix is disclosed. The method involves incorporating into the matrix, along with the granules, from about 10% to about 50% by weight microcrystalline cellulose.
Inventors
- 👤 Wallace E. Becker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61J; A61J3/00; A61J3/10
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
75 words
In an improved method of making a pharmaceutical tablet comprised of a tablet matrix of friable enteric or controlled release coated fracturable granules and the tablet having a hardness sufficient to resist an applied fracturing pressure of at least 15kg/in 2 , the improvement comprising: incorporating into the matrix prior to applying at least said fracturing pressure, microcrystalline cellulose in the amount of from about 10% to about 50%, by weight of the total matrix.
Claim 2
Dependent Claim
75 words
In an improved method of making a pharmaceutical tablet comprised of a tablet matrix of friable enteric or controlled release coated fracturable granules and the tablet having a hardness sufficient to resist an applied fracturing pressure of at least 15kg/in 2 , the improvement comprising: incorporating into the matrix prior to applying at least said fracturing pressure, microcrystalline cellulose in the amount of from about 10% to about 50%, by weight of the total matrix.
Claim 3
Dependent Claim
13 words
A method according to claim 1, wherein the granules have an enteric coating.
Claim 4
Dependent Claim
14 words
A method according to claim 2 wherein the matrix further comprises noncoated drug granules.
Claim 5
Dependent Claim
20 words
A method according to claim 3 wherein the noncoated granules comprise the same drug as the friable enteric coated granules.
Claim 6
Dependent Claim
24 words
A method according to claim 3 wherein the noncoated drug granules contain a drug different from the drug in the friable enteric coated granules.
References Cited (Backward Citations)
US2099402A
Cited
US2953497A
Cited
US2996431A
Cited
US2866735A
Cited
US2798024A
Cited
US2853420A
Cited
US2928770A
Cited
US3081233A
Cited
US3115441A
Cited
US3119742A
Cited
US3488418A
Cited
US4025613A
Cited
US3906086A
Cited
US3860733A
Cited
US3865935A
Cited
US3883647A
Cited
US3927194A
Cited
US3954959A
Cited
US3891755A
Cited
US3922338A
Cited
US3961041A
Cited
US4079125A
Cited
US4076804A
Cited
US4250166A
Cited
US4173626A
Cited
US4289751A
Cited
US4432966A
Cited
US4459295A
Cited
US4259315A
Cited
US4340582A
Cited
EP0063266A2
Cited
US4434152A
Cited
US4370313A
Cited
US4415547A
Cited
US4461759A
Cited
US4555399A
Cited
US4599326A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-16 | 1993-04-17 | 1993-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-16 | 1997-04-17 | 1997-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-16 | 2001-04-17 | 2001-10-17 | $7700.00 | Window Closed / Lapsed |