US3922338A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tablets containing in their mass controlled-release micro-capsules and process for manufacture of said tablets
Assignee: Choay SA
•
Filing: 1974-07-10
•
Granted: 1975-11-25
•
Expires: 1994-07-10
Abstract
Abstract The present invention relates to new tablets for administration of medicaments, which tablets contain in their mass, controlledrelease microcapsules, that is to say elemental particles coated with a protective covering which contains an encapsulated product which is gradually released in a controlled, regular and timedependent way. These new tablets are characterised in that they are constituted by the association of a plurality of superposed layers of which the medial layer is essentially constituted by microcapsules containing an active substance, whilst the exterior layers constitute means of protecting the microcapsules of the medial layer, particularly against the shock of compression when compressing them to tablets. The invention also relates to a process for manufacturing said tablets.
Inventors
- 👤 Yvette Fr M J Estevenel
- 👤 Maurice H Thely
- 👤 Wladimir A Coulon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2086; A61K9/209; A61J; A61J3/00; A61J3/07; A61J3/10; A61K9/2077; A61K9/2081
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
82 words
COMPRESSED LAYERED TABLETS CONTAINING, IN THEIR MASS, CONTROLLED-RELEASE MICROCAPSULES, COMPRISING THE ASSOCIATION OF A PLURALITY OF SUPERPOSED LAYERS, OF WHICH THE MEDIAL LAYER ESSENTIALLY COMPRISES MICROCAPSULES CONTANING AN ACTIVE SUBSTANCE, WHILE THE EXTERIOR LAYERS, WHICH HAVE A MICROCRYSTALLINE CELLULOSE, STARCH, ALGINATE, OR POLYOXY ETHYLENE GLYCOL TABLET EXCIPIENT COMPOSITION, CONSTITUTE MEANS OF PROTECTING THE MICROCAPSULES OF THE MEDIAL LAYER, PARTICULARLY AGAINST THE SHOCK OF COMPRESSION, SAID TABLET EXCIPIENT COMPOSITION BEING IN THE FROM OF GRANULES HAVING THE SAME GRAIN SIZE AS SAID MICROCAPSULES.
Claim 2
Dependent Claim
82 words
COMPRESSED LAYERED TABLETS CONTAINING, IN THEIR MASS, CONTROLLED-RELEASE MICROCAPSULES, COMPRISING THE ASSOCIATION OF A PLURALITY OF SUPERPOSED LAYERS, OF WHICH THE MEDIAL LAYER ESSENTIALLY COMPRISES MICROCAPSULES CONTANING AN ACTIVE SUBSTANCE, WHILE THE EXTERIOR LAYERS, WHICH HAVE A MICROCRYSTALLINE CELLULOSE, STARCH, ALGINATE, OR POLYOXY ETHYLENE GLYCOL TABLET EXCIPIENT COMPOSITION, CONSTITUTE MEANS OF PROTECTING THE MICROCAPSULES OF THE MEDIAL LAYER, PARTICULARLY AGAINST THE SHOCK OF COMPRESSION, SAID TABLET EXCIPIENT COMPOSITION BEING IN THE FROM OF GRANULES HAVING THE SAME GRAIN SIZE AS SAID MICROCAPSULES.
Claim 3
Dependent Claim
13 words
Tables according to claim 1, wherein said exterior layers also contain active substances.
Claim 4
Dependent Claim
17 words
Tablets according to claim 2, wherein said active substances contained in the exterior layers are identical substances.
Claim 5
Dependent Claim
21 words
Tablets according to claim 2, wherein said active substances contained in each of the exterior layers are different from each other.
Claim 6
Dependent Claim
34 words
Tablets according to claim 1, wherein said tablets have a hardness of the order of 10 to 20 kg on their surface and of the order of 8 to 16 kg on their periphery.
Claim 7
Dependent Claim
33 words
Tablets according to claim 1, wherein the ratio between the sum of the thicknesses of the external layers and the thickness of the medial layer containing the microcapsules, is between 0.8 and 4.
Claim 8
Dependent Claim
33 words
Tablets according to claim 1, wherein the ratio between the sum of the thicknesses of the external layers and the thickness of the medial layer containing the microcapsules is between 1 and 2.4.
References Cited (Backward Citations)
US462990A
Cited
US3048526A
Cited
US3096248A
Cited
US3341416A
Cited
US3488418A
Cited
US3524910A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-24 | 1979-05-26 | 1979-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-24 | 1983-05-26 | 1983-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-24 | 1987-05-26 | 1987-11-25 | $7700.00 | Window Closed / Lapsed |