Patent US4105637A successfully refreshed from Google Patents.
US4871357A
Expired / Lapsed
US
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Ionic heparin coating
Assignee: Edwards Lifesciences Corp
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Filing: 1987-09-14
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Granted: 1989-10-03
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Expires: 2007-09-14
Abstract
Abstract A non thrombogenic quarternary ammonium/heparin complex coating for a medical article is disclosed where the organic cationic salt is an alkylbenzyldimethyl ammonium ion present in an amount of at least 50% by weight and having the following formula: <IMAGE> where R is a uniform alkyl group containing between 16 to 18 carbon atoms.
Inventors
- 👤 Li-Chien Hsu
- 👤 Sun D. Tong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:24
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A blood contacting medical article comprising: (a) a substrate polymeric surface; and (b) an anti-thrombogenic, saline stable surface coating of a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt having the following formula: ##STR5## where R is an alkyl group having from 16 to 18 carbon atoms.
Claim 2
Dependent Claim
55 words
A blood contacting medical article comprising: (a) a substrate polymeric surface; and (b) an anti-thrombogenic, saline stable surface coating of a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt having the following formula: ##STR5## where R is an alkyl group having from 16 to 18 carbon atoms.
Claim 3
Dependent Claim
11 words
The medical article of claim 1 wherein complex is cetalkonium heparin.
Claim 4
Dependent Claim
12 words
The medical article of claim 2 wherein the complex is stearylkonium heparin.
Claim 5
Dependent Claim
14 words
The medical article of claim 1 wherein the substrate surface comprises a polymeric resin.
Claim 6
Dependent Claim
26 words
The medical article of claim 1 wherein the organic cationic salt is present in an amount of 60 to 70% by weight of the complex composition.
Claim 7
Dependent Claim
59 words
A process for rendering the polymeric surfaces of blood contacting medical articles non-thrombogenic comprising: (a) providing a medical article; and (b) coating the medical article with a complex of heparin and at least 50%, by weight of an alkylbenzyl dimethyl ammonium cationic salt of the formula: ##STR6## where R is an alkyl group from 16 to 18 carbon atoms.
Claim 8
Dependent Claim
59 words
A process for rendering the polymeric surfaces of blood contacting medical articles non-thrombogenic comprising: (a) providing a medical article; and (b) coating the medical article with a complex of heparin and at least 50%, by weight of an alkylbenzyl dimethyl ammonium cationic salt of the formula: ##STR6## where R is an alkyl group from 16 to 18 carbon atoms.
Claim 9
Dependent Claim
43 words
The process of claim 6 wherein the coating step comprises: (a) providing an organic solution of the heparin complex; (b) applying the solution to the surface of a medical article; and (c) drying the medical article to form an integral adhesive coating thereon.
Claim 10
Dependent Claim
62 words
A process of claim 6 wherein the coating step comprises: (a) treating the medical article with a solution of a cationic quarternary ammonium organic salt having the following formula: ##STR7## where R is an alkyl group containing from 16 to 18 carbon atoms and X is a halogen; and (b) subsequently treating the medical article with an aqueous solution of heparin salt.
Claim 11
Dependent Claim
39 words
A blood contacting saline stable coating comprising: a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt of the formula: ##STR8## wherein: R is a C 16 to C 18 alkyl grouping.
Claim 12
Dependent Claim
39 words
A blood contacting saline stable coating comprising: a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt of the formula: ##STR8## wherein: R is a C 16 to C 18 alkyl grouping.
Claim 13
Dependent Claim
13 words
The blood contacting article of claim 9 wherein said complex is cetalkonium heparin.
Claim 14
Dependent Claim
13 words
The blood contacting article of claim 9 wherein said complex is stearylkonium heparin.
Claim 15
Dependent Claim
23 words
The blood contacting article of claim 9 wherein ammonium salt comprises from about sixty to about seventy percent by weight of the complex.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |