US3639213A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Streptokinase chemically bonded to a carbohydrate matrix
Assignee: Baxter International Inc
•
Filing: 1969-12-02
•
Granted: 1972-02-01
•
Expires: 1989-12-02
Abstract
Abstract One part by weight of streptokinase is chemically bonded to 1 to 500 parts by weight of a carbohydrate, to form a material which has improved stability compared with free streptokinase.
Inventors
- 👤 Leonard George Ginger
- 👤 Adaline Nicoles Mather
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:14
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/164; A61K38/166; C; C12; C12N; C12N11/00; C12N11/02; C12N11/10
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
16 words
The composition of claim 1 in which said dextran support medium is modified with carboxyalkyl groups.
Claim 2
Dependent Claim
27 words
The composition of claim 1 in which from 10 to 200 parts by weight of said dextran support medium are present per part by weight of streptokinase.
Claim 3
Dependent Claim
69 words
The composition of claim 1 in which said streptokinase is bonded to a dextran support medium by at least one moiety shown within the brackets of the formula in which R is said dextran support medium having a bond on an oxygen atom thereof connected to said moiety, R'' is said streptokinase having a bond connected to said moiety on an atom thereof and n is a positive integer.
Claim 4
Dependent Claim
26 words
The composition of claim 4 in which from 10 to 200 parts by weight of said support medium are present per part by weight of streptokinase.
Claim 5
Dependent Claim
15 words
The composition of claim 5 in which n has a value of one to two.
Claim 6
Dependent Claim
14 words
the composition of claim 6 in which said support medium is a carboxylakyl dextran.
Claim 7
Dependent Claim
28 words
The composition of claim 1 in which said streptokinase is bonded to a dextran support medium by at least one moiety shown within the brackets of the formula
Claim 8
Dependent Claim
27 words
The composition of claim 8 in which from 10 to 200 parts bY weight of said dextran support medium are present per part by weight of streptokinase.
Claim 9
Dependent Claim
10 words
The composition of claim 9 in which X is chlorine.
Claim 10
Dependent Claim
52 words
The process of contacting a dextran with cyanogen bromide under alkaline conditions to form a reaction product therebetween, and thereafter contacting one part by weight of streptokinase with from 1 to 500 parts by weight of said reaction product to form a chemically bonded water soluble adduct comprising said dextran and streptokinase.
Claim 11
Dependent Claim
11 words
The chemically bonded adduct prepared by the process of claim 11.
Claim 12
Dependent Claim
26 words
The composition of claim 12 produced by contacting from 10 to 200 parts by weight of said reaction product with one part by weight of streptokinase.
Claim 13
Dependent Claim
23 words
The composition of claim 13 in which said alkaline conditions used for preparing said reaction product constitute a pH of at least 11.
Claim 14
Dependent Claim
54 words
The process of contacting from 1 to 500 parts by weight of a dextran, having pendant groups of the formula bonded to oxygen atoms of said carbohydrate, with one part by weight of streptokinase to form a water soluble covalently bonded adduct of said dextran and streptokinase, in which n is a positive integer.
Claim 15
Dependent Claim
69 words
The process of contacting (1) from 1 to 500 parts by weight of the reaction product of a dextran and a compound of the formula in which X is selected from the group consisting of halogen, hydrogen, and monovalent hydrocarbon radicals of no more than 4 carbon atoms with (2) one part by weight of streptokinase to form a water soluble covalently bonded adduct of said dextran and streptokinase.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-01-31 | 1975-08-02 | 1976-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-01-31 | 1979-08-02 | 1980-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-01-31 | 1983-08-02 | 1984-02-01 | $7700.00 | Window Closed / Lapsed |