US3865615A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Non-thrombogenic plastics
Assignee: Air Products and Chemicals Inc
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Filing: 1973-05-07
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Granted: 1975-02-11
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Expires: 1993-05-07
Abstract
Abstract Non-thrombogenic plastic materials are prepared by a process which first fluorinates polyolefins or polyesters under conditions which produce both fluoride groups and reactive carboxyl groups and then reacts the carboxyl group on the substrate with plasminokinase enzymes which activate plasminogene to plasmin. Such treated plastic materials can be used in devices, coming in direct contact with blood without accelerating clotting, as in membranes for blood dialysis and in other extracorporeal biomedical devices as well as in devices and conduits intended for prosthesis or body implants.
Inventors
- 👤 Donald G Manly
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:42
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0047; C08F; C08F8/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
25 words
NON-THROMBOGENIC PLASTIC COMPRISING A FLUORINATED POLYMERIC PLASTIC FROM THE GROUP CONSISTING OF POLYOLEFINS AND POLYESTERS HAVING CHEMICALLY BOND DIRECTLY THERETO THROUGH AMIDO LINKAGES A PLASMINOKINASE.
Claim 2
Dependent Claim
25 words
NON-THROMBOGENIC PLASTIC COMPRISING A FLUORINATED POLYMERIC PLASTIC FROM THE GROUP CONSISTING OF POLYOLEFINS AND POLYESTERS HAVING CHEMICALLY BOND DIRECTLY THERETO THROUGH AMIDO LINKAGES A PLASMINOKINASE.
Claim 3
Dependent Claim
13 words
A product as defined in claim 1 wherein said polyolefin is a polyethylene.
Claim 4
Dependent Claim
12 words
The product as defined in claim 2 wherein said plasminokinase is urokinase.
Claim 5
Dependent Claim
12 words
The product as defined in claim 2 wherein said plasminokinase is streptokinase.
Claim 6
Dependent Claim
14 words
A product as defined in claim 1 wherein said polyester is a polyethylene terephthalate.
Claim 7
Dependent Claim
12 words
The product as defined in claim 5 wherein said plasminokinase is urokinase.
Claim 8
Dependent Claim
12 words
The product as defined in claim 5 wherein said plasminokinase is streptokinase.
Claim 9
Dependent Claim
12 words
The product as defined in claim 1 wherein said plasminokinase is urokinase.
Claim 10
Dependent Claim
12 words
The product as defined in claim 1 wherein said plasminokinase is streptokinase.
Claim 11
Independent Claim
55 words
THE METHOD OF IMPARTING ANTITHROMBOGENIC PROPERTIES TO THE SURFACE OF A PLASTIC MATERIAL FROM THE GROUP CONSISTING OF POLYOLEFINS AND POLYESTERS WHICH COMPRISES FLUORINATING SUCH PLASTIC MATERIAL UNDER CONDITIONS TO FORM ASSOCIATED CARBOXYLIC MOIETIES THEREIN AND CHEMICALLY BINDING THERETO THROUGH SUCH CARBOXYLIC MOIETIES A PLASMINOGEN ACTIVATOR SELECTED FROM THE GROUP CONSISTING OF UROKINASE ANS STREPTOKIMASE.
Claim 12
Independent Claim
55 words
THE METHOD OF IMPARTING ANTITHROMBOGENIC PROPERTIES TO THE SURFACE OF A PLASTIC MATERIAL FROM THE GROUP CONSISTING OF POLYOLEFINS AND POLYESTERS WHICH COMPRISES FLUORINATING SUCH PLASTIC MATERIAL UNDER CONDITIONS TO FORM ASSOCIATED CARBOXYLIC MOIETIES THEREIN AND CHEMICALLY BINDING THERETO THROUGH SUCH CARBOXYLIC MOIETIES A PLASMINOGEN ACTIVATOR SELECTED FROM THE GROUP CONSISTING OF UROKINASE ANS STREPTOKIMASE.
Claim 13
Dependent Claim
29 words
The method as defined in claim 10 wherein the fluorinated plastic containing carboxylic moieties is esterified by reaction with a carbodiimide compound prior to reaction with said plasminogen activator.
Claim 14
Dependent Claim
28 words
The method as defined in claim 10 wherein said conditions to form associated carboxylic moieties includes the step of subjecting the fluorinated plastic material to contact with water.
Claim 15
Dependent Claim
12 words
The method as defined in claim 11 wherein said polyolefin is polyethylene.
Claim 16
Independent Claim
57 words
THE METHOD WHICH COMPRISES SUBJECTING POLYETHYLENE TO A GASEOUS MIXTURE CONTAINING OXYGEN AND FLUORINE, SAID OXYGEN BEING PRESENT IN A VOLUME RATIO OF 0.5/1 TO 20/1 TO FLUORINE IN SAID GASEOUS MIXTURE, FURTHER REACTING THE OBTAINED OXYFLUORINATED POLYETHYLENE WITH AN AQUEOUS SOLUTION OF UROKINASE FOLLOWED BY FIXING THE THUS BONDED UROKINASE BY FURTHER REACTION WITH HEXAMETHYLENE DIAMINE.
Claim 17
Independent Claim
57 words
THE METHOD WHICH COMPRISES SUBJECTING POLYETHYLENE TO A GASEOUS MIXTURE CONTAINING OXYGEN AND FLUORINE, SAID OXYGEN BEING PRESENT IN A VOLUME RATIO OF 0.5/1 TO 20/1 TO FLUORINE IN SAID GASEOUS MIXTURE, FURTHER REACTING THE OBTAINED OXYFLUORINATED POLYETHYLENE WITH AN AQUEOUS SOLUTION OF UROKINASE FOLLOWED BY FIXING THE THUS BONDED UROKINASE BY FURTHER REACTION WITH HEXAMETHYLENE DIAMINE.
Claim 18
Dependent Claim
19 words
The method according to claim 14 wherein said gaseous mixture comprises about 95 percent oxygen and 5 percent fluorine.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-02-10 | 1978-08-12 | 1979-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-02-10 | 1982-08-12 | 1983-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-02-10 | 1986-08-12 | 1987-02-11 | $7700.00 | Window Closed / Lapsed |