US20060147545A1
Expired / Lapsed
US
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Volume maintaining osteoinductive/osteoconductive compositions
Assignee: Individual
•
Filing: 2005-11-22
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Granted: —
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Expires: 2025-11-22
Abstract
Abstract An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
Inventors
- 👤 Nelson Scarborough
- 👤 Sergio Gadaleta
- 👤 David Kaes
- 👤 Albert Manrique
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/32; A61P; A61P19/00; Y; Y10; Y10S; Y10S606/00; Y10S606/907; Y10S606/909
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
71 words
1 . An osteoinductive and osteoconductive composition comprising: (a) a quantity of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, (b) a quantity of shaped non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less, and (c) a biocompatible fluid carrier, wherein the composition withstands a compressive force greater than 7.9 N without substantial deformation.
Claim 2
Dependent Claim
71 words
1 . An osteoinductive and osteoconductive composition comprising: (a) a quantity of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, (b) a quantity of shaped non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less, and (c) a biocompatible fluid carrier, wherein the composition withstands a compressive force greater than 7.9 N without substantial deformation.
Claim 3
Dependent Claim
74 words
2 . The osteoinductive and osteoconductive composition of claim 1 of which about 50 to about 100 percent by weight of the fibrous bone element is made up of demineralized fibrous bone elements having a median length of from about 2 mm to about 400 mm, a median thickness of from about 0.05 mm to about 2 mm and a median length to median thickness ratio of at least 10:1 up to about 500:1.
Claim 4
Dependent Claim
35 words
3 . The osteoinductive and osteoconductive composition of claim 1 in which a shape of the non-fibrous bone elements is selected from the group consisting of triangular prism, sphere, cube, cylinder and other regular shapes.
Claim 5
Dependent Claim
43 words
4 . The osteoinductive and osteoconductive composition of claim 1 wherein the bone elements are obtained from cortical autogenic, cortical allogenic, cortical xenogenic cancellous autogenic, cancellous allogenic, cancellous xenogenic, cortical transgenic, cancellous transgenic, corticocancellous autogenic, corticocancellous allogenic, corticocancellous xenogenic or corticocancelldus transgenic bone.
Claim 6
Dependent Claim
89 words
5 . The osteoinductive and osteoconductive composition of claim 1 of which about 20 to about 80 weight percent of the non-fibrous bone elements of the invention are non-fibrous bone elements having a median length to median width to median height ratio of at least about 1:0.3:1 and up to about 1:5:1, a imedian length of from about 1 mm to about 10 mm, a median width of from about 1 mm to about 10 mm and a median height of from about 1 mm to about 10 mm.
Claim 7
Dependent Claim
25 words
6 . The osteoinductive and osteoconductive composition of claim 1 wherein about 0 to about 50 percent by weight of the bone elements are mineralized.
Claim 8
Dependent Claim
26 words
7 . The osteoinductive and osteoconductive composition of claim 1 wherein about 0 to about 80 percent by weight of the bone elements are partially demineralized.
Claim 9
Dependent Claim
25 words
8 . The osteoinductive and osteoconductive composition of claim 1 wherein about 0 to about 100 percent by weight of the bone elements are demineralized.
Claim 10
Dependent Claim
15 words
9 . The osteoinductive and osteoconductive composition of claim 1 further comprising a thixotropic agent.
Claim 11
Dependent Claim
18 words
10 . The osteoinductive and osteoconductive composition of claim 1 further comprising at least one medically/surgically useful substance.
Claim 12
Dependent Claim
17 words
11 . The osteoinductive and osteoconductive composition of claim 1 wherein the fibrous bone elements are entangled.
Claim 13
Dependent Claim
24 words
12 . The osteoinductive and osteoconductive composition of claim 11 wherein the non-fibrous bone elements are thoroughly mixed in the entangled fibrous bone elements.
Claim 14
Dependent Claim
45 words
13 . The osteoinductive and osteoconductive composition of claim 1 containing from about 20 to about 70 weight percent demineralized fibrous bone elements, from about 20 to about 70 weight percent non-fibrous bone elements, and from about 10 to about 80 weight percent fluid carrier.
Claim 15
Dependent Claim
24 words
14 . The osteoinductive and osteoconductive composition of claim 1 wherein the ratio of fibrous to non-fibrous elements is about 0.2:1 to about 1:0.2.
Claim 16
Dependent Claim
50 words
15 . The osteoinductive and osteoconductive composition of claim 1 further comprising at least one additive selected from the group consisting of autograft bone marrow aspirate, autograft bone, preparations of selected autograft cells, autograft cells containing genes encoding bone promoting action and autograft cells expanded outside the body and returned.
Claim 17
Dependent Claim
26 words
16 . The osteoinductive and osteoconductive composition of claim 1 wherein the composition withstands a compressive force of at least about 10.3 N without significant deformation.
Claim 18
Dependent Claim
26 words
17 . The osteoinductive and osteoconductive composition of claim 1 wherein the amount of mineral remaining in the elements allows for radiographic imaging of the composition.
Claim 19
Dependent Claim
32 words
18 . The osteoinductive and osteoconductive composition of claim 1 further comprising at least one radiopaque material selected from the group consisting of barium sulfate, iodine containing compounds, titanium and mineralized bone.
Claim 20
Dependent Claim
26 words
19 . method of using the osteoinductive and osteoconductive composition of claim 1 wherein the composition is packed appropriately into an appropriate size bone defect site.
Claim 21
Dependent Claim
33 words
20 . The method of claim 19 wherein the composition is packed into the defect site utilizing at least one means selected from the group consisting of spatula, forceps, syringe and dental equipment.
Claim 22
Dependent Claim
44 words
21 . The method of claim 19 wherein the defect site is selected from the group consisting of ulna defects, metaphyseal defects, tibia plateau defects, acetabular defects, sinus defects, long bone cortical defects, cranial defects, ilium defects, wrist/hand defects, ankle/foot defects and oral/maxillofacial defects.
Claim 23
Dependent Claim
50 words
22 . The method of claim 19 wherein the composition further comprises at least one additional additive selected from the group consisting of autograft bone marrow aspirate, autograft bone, autograft cell preparations, autograft cells containing genes encoded for bone stimulating activity and autograft cells expanded outside the body and returned.
Claim 24
Dependent Claim
75 words
23 . The osteoinductive and osteoconductive composition of claim 1 containing about X weight units of component (a), about Y weight units of component (b) and about Z weight units of component (c) a given amount of the composition exhibiting a greater resistance to deformation than the identical amount of a second osteoinductive and osteoconductive composition containing X+Y weight units of component (a), no amount of component (b) and Z weight units of component (c).
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