US6426145B1 — Radiopaque compositions for visualization of medi…

Claim 1

Independent Claim 238 words

A radiopaque polymeric composition having the formula wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and a halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 2

Dependent Claim 238 words

A radiopaque polymeric composition having the formula wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and a halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 3

Dependent Claim 45 words

A radiopaque polymeric composition according to claim 1 wherein the substituted or unsubstituted aromatic or aliphatic carbon groups of R 1 and R 3 are a polymeric group, said group being selected from the group consisting of polyester, polyether, polycarbonate, polyamide, or polyester polyamide copolymer.

Claim 4

Dependent Claim 27 words

A radiopaque polymeric composition according to claim 1 wherein R 2 forms an ester group connected to an said aromatic or aliphatic group of R 3 .

Claim 5

Dependent Claim 17 words

A radiopaque polymeric composition according to claim 1 wherein the radiopaque component includes an iodinated aromatic ring.

Claim 6

Dependent Claim 14 words

A radiopaque polymeric composition according to claim 1 which is both biocompatible and biodegradable.

Claim 7

Dependent Claim 16 words

A radiopaque polymeric composition according to claim 1 wherein the polymeric composition is not cross linked.

Claim 8

Dependent Claim 16 words

A radiopaque polymeric composition according to claim 1 applied to the substrate of a medical device.

Claim 9

Dependent Claim 13 words

A medical device according to claim 6 wherein the medical device is implantable.

Claim 10

Dependent Claim 49 words

A radiopaque polymeric composition according to claim 1 wherein R 4 , R 5 and R 6 are chosen to impart characteristics which alter one or more of the composition's properties, said properties being selected from the group consisting of adhesion, crystallinity, tackiness, lubricity, hemocompatibility, cell compatibility, and flexibility.

Claim 11

Dependent Claim 250 words

A medical device having at least one radiopaque surface, said radiopaque surface comprising: a polymeric composition having the formula wherein A is a substituted or unsubstituted aromatic or aliphatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato and halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 12

Dependent Claim 250 words

A medical device having at least one radiopaque surface, said radiopaque surface comprising: a polymeric composition having the formula wherein A is a substituted or unsubstituted aromatic or aliphatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato and halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 13

Dependent Claim 43 words

A medical device according to claim 10 wherein R 1 and R 3 of the polymeric composition which comprises the radiopaque surfaces are a polymeric group, said group being selected from the group consisting of polyester, polyether, polycarbonate, polyamide, or polyester polyamide copolymer.

Claim 14

Dependent Claim 20 words

A medical device according to claim 10 wherein the polymeric composition which comprises the radiopaque surface includes an iodinated ring.

Claim 15

Dependent Claim 21 words

A medical device according to claim 10 wherein the polymeric composition which comprises the radiopaque surface is both biocompatible and biodegradable.

Claim 16

Dependent Claim 20 words

A medical device according to claim 10 wherein the polymeric composition which comprises the radiopaque surface is not cross linked.

Claim 17

Dependent Claim 13 words

A medical device according to claim 10 wherein such device is a graft.

Claim 18

Dependent Claim 13 words

A medical device according to claim 10 wherein such device is a stent.

Claim 19

Dependent Claim 13 words

A medical device according to claim 10 wherein such device is a catherer.

Claim 20

Independent Claim 261 words

A method of imparting a radiopaque polymeric coating to a surface of an article which comprises: a) contacting said surface with a radiopaque polymeric composition, said composition having the following formula: wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 21

Independent Claim 261 words

A method of imparting a radiopaque polymeric coating to a surface of an article which comprises: a) contacting said surface with a radiopaque polymeric composition, said composition having the following formula: wherein A is a substituted or unsubstituted aromatic or aliphatic group containing a radiopaque component and a functional group, said functional group being capable of forming a linkage with R 1 and is selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; R 1 and R 3 are different substituted or unsubstituted aliphatic or aromatic groups having from 1 to 20 carbons, and having at least two reactive ends being the same or different, said reactive ends being selected from the group consisting of carboxyl, amino, hydroxyl, isocyanato, and halo; x is an integer from 1 to 1,000; n is an integer from 1 to 1,000; R 2 , R 7 , and R 8 may be optionally present, and may be the same or different, substituted or unsubstituted groups selected from the difunctional groups consisting of diols, diamines, hydroxy acids, and amino acids; R 4 , R 5 , and R 6 may be the same or different substituents selected from the group consisting of hydrogen, halogen, or a hydrocarbon chain having from 1 to 100 carbons; R 9 is an optional chain extender containing at least two end groups being the same or different and selected from the group consisting of amino, hydroxyl, carbonate, anhydride, acyl chloride, and carboxyl; p is an integer from 1 to 100; q is an integer from 1 to 100.

Claim 22

Dependent Claim 12 words

The method of claim 18 wherein said article is a medical device.

Claim 23

Dependent Claim 11 words

The method of claim 18 wherein said article is a graft.

Claim 24

Dependent Claim 11 words

The method of claim 18 wherein said article is a stent.

Claim 25

Dependent Claim 11 words

The method of claim 18 wherein said article is a catherer.

Claim 26

Dependent Claim 14 words

The method of claim 18 wherein said contacting is by dipping, brushing or spraying.

Claim 27

Dependent Claim 28 words

The method of claim 18 wherein said contacting further comprises applying from about 0 to 100 layers of the radiopaque polymeric composition to the surface of said article.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2005-07-29	2006-01-28	2006-07-30	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2009-07-29	2010-01-28	2010-07-30	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2013-07-29	2014-01-28	2014-07-30	$7700.00	Window Closed / Lapsed

Radiopaque compositions for visualization of medical devices

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