Polymeric X-ray compositions containing iodinated polymeric beads

Claim 1

A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral or rectal administration to the patient an x-ray contrast composition designed for depositing a thin, flexible film membrane onto the mucosal lining of the nutrient absorbing inner surface of the intestine of a patient to form a barrier between said nutrient absorbing inner surface and the content of said intestine, said flexible film membrane to remain bound to said mucosal lining until eliminated by normal cell turnover comprising based on w/v; (a) of from about 0.001 to about 25% of a polymeric material capable of forming a film membrane on the gastrointestinal tract in the pH range of form about 5 to 8, said polymeric material being selected from the group consisting of: dermatan sulfate, hepatosulfate, hyabromic acid, heparin, chitin, polyvinylpyrrolidone, polyvinyl alcohol and ethylene oxide; (b) of from about 0.1 to about 20% of a divalent cation to potentiate the binding of said flexible film membrane to said mucosal lining selected from the group consisting of Ca ++ , Mg ++ , Zn ++ and Ba ++ ; and c) of from about 5 to about 95% of an iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000μ wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR12## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing an iodinated aromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based on the molecular weight of X, in a liquid pharmaceutically acceptable carrier comprising: a surfactant selected from the group consisting of cetyltrimethyl ammonium bromide, dodecyl ammonium bromide, sodium lauryl sulfate, sodium heptadecyl sulfate, alkyl benzene sulfonic acid, sodium butylnaphthalene sulfonate, sodium butylnaphthalene sulphosucinate, carboxylic esters, carboxylic amides, ethoxylated alkylphenols, ethoxylated aliphatic alcohols, sorbitan esters, polyoxyethylene alkyl ethers and polyoxyethylene sorbitan fatty acid esters; and exposing the gastrointestinal tract containing said x-ray contrast composition to x-rays to form an x-ray image pattern corresponding to the presence of said x-ray contrast composition, and visualizing said image pattern.

Claim 2

A method of carrying out x-ray examination of the gastrointestinal tract of a patient, said method comprises the oral or rectal administration to the patient an x-ray contrast composition designed for depositing a thin, flexible film membrane onto the mucosal lining of the nutrient absorbing inner surface of the intestine of a patient to form a barrier between said nutrient absorbing inner surface and the content of said intestine, said flexible film membrane to remain bound to said mucosal lining until eliminated by normal cell turnover comprising based on w/v; (a) of from about 0.001 to about 25% of a polymeric material capable of forming a film membrane on the gastrointestinal tract in the pH range of form about 5 to 8, said polymeric material being selected from the group consisting of: dermatan sulfate, hepatosulfate, hyabromic acid, heparin, chitin, polyvinylpyrrolidone, polyvinyl alcohol and ethylene oxide; (b) of from about 0.1 to about 20% of a divalent cation to potentiate the binding of said flexible film membrane to said mucosal lining selected from the group consisting of Ca ++ , Mg ++ , Zn ++ and Ba ++ ; and c) of from about 5 to about 95% of an iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000μ wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) ##STR12## wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing an iodinated aromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based on the molecular weight of X, in a liquid pharmaceutically acceptable carrier comprising: a surfactant selected from the group consisting of cetyltrimethyl ammonium bromide, dodecyl ammonium bromide, sodium lauryl sulfate, sodium heptadecyl sulfate, alkyl benzene sulfonic acid, sodium butylnaphthalene sulfonate, sodium butylnaphthalene sulphosucinate, carboxylic esters, carboxylic amides, ethoxylated alkylphenols, ethoxylated aliphatic alcohols, sorbitan esters, polyoxyethylene alkyl ethers and polyoxyethylene sorbitan fatty acid esters; and exposing the gastrointestinal tract containing said x-ray contrast composition to x-rays to form an x-ray image pattern corresponding to the presence of said x-ray contrast composition, and visualizing said image pattern.