US5567410A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Composotions and methods for radiographic imaging
Assignee: General Hospital Corp
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Filing: 1994-06-24
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Granted: 1996-10-22
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Expires: 2014-06-24
Abstract
Abstract A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporating radiopaque molecules via covalent bonds.
Inventors
- 👤 Vladimir P. Torchilin
- 👤 Vladimir S. Trubetskoy
- 👤 Gerald L. Wolf
- 👤 G. Scott Gazelle
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:32
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0461; A61K49/0466; A61K49/0442; A61K49/0471; C; C07; C07C; C07C233/00; C07C233/01; C07C233/45; C07C233/53; C07C233/54; C07C237/00; C07C237/28; C07C237/46; C08; C08G; C08G81/00; Y; Y10; Y10S; Y10S977/00; Y10S977/902; Y10S977/904; Y10S977/927; Y10S977/928
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
49 words
A compound capable of reversibly forming micelles in an aqueous solution, said compound comprising a hydrophilic polymer linked to a hydrophobic polymer, and said hydrophobic polymer comprising a backbone incorporating radiopaque molecules via covalent bonds, wherein said micelles dissociate in vivo into said compound over a 24 hour period.
Claim 2
Dependent Claim
49 words
A compound capable of reversibly forming micelles in an aqueous solution, said compound comprising a hydrophilic polymer linked to a hydrophobic polymer, and said hydrophobic polymer comprising a backbone incorporating radiopaque molecules via covalent bonds, wherein said micelles dissociate in vivo into said compound over a 24 hour period.
Claim 3
Dependent Claim
31 words
A compound of claim 1, wherein said hydrophilic polymer is polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, poly-(N-hydroxypropyl)-methacrylamide, polyvinylalcohol, a polymethacrylate, a polysaccharide, a polyamino acid, or a polyacrylic ester, or a derivative thereof.
Claim 4
Dependent Claim
12 words
A compound of claim 1, wherein said hydrophilic polymer is polyethylene glycol.
Claim 5
Dependent Claim
35 words
A compound of claim 1, wherein said backbone is an amino-containing polymer, a polymer of amino acids, a polycarboxylic acid, a polyanhydride, a polyhydroxy acid, a polysaccharide, polystyrene, polyisoprene, polyalkalene oxide, or a derivative thereof.
Claim 6
Dependent Claim
10 words
A compound of claim 4, wherein said backbone is poly-L-lysine.
Claim 7
Dependent Claim
16 words
A compound of claim 1, wherein said radiopaque molecule comprises an element with a heavy nucleus.
Claim 8
Dependent Claim
11 words
A compound of claim 6, wherein said radiopaque molecule comprises iodine.
Claim 9
Dependent Claim
15 words
A compound of claim 7, wherein said radiopaque molecule is diatrizoate, iothalamate, metrizoate, or iodipamide.
Claim 10
Dependent Claim
12 words
A compound of claim 1, wherein said radiopaque molecule is triiodobenzoic acid.
Claim 11
Dependent Claim
11 words
A compound of claim 1, wherein said radiopaque molecule comprises bromine.
Claim 12
Dependent Claim
13 words
A compound of claim 10, wherein said radiopaque molecule is perfluorooctyl bromide (PFOB).
Claim 13
Dependent Claim
30 words
A compound of claim 1, wherein said hydrophilic polymer has a molecular weight of 10,000 to 15,000 daltons, and said backbone has a molecular weight of 3000 to 6000 daltons.
Claim 14
Dependent Claim
17 words
A compound of claim 1, wherein said hydrophilic polymer is polyethylene glycol, and said backbone is poly-L-lysine.
Claim 15
Dependent Claim
26 words
A compound of claim 13, wherein said polyethylene glycol has a molecular weight of 12,000 daltons, and said hydrophobic polymer has a molecular weight of 9,000.
Claim 16
Dependent Claim
12 words
A compound of claim 14, wherein said radiopaque molecule is triiodobenzoic acid.
Claim 17
Dependent Claim
50 words
A method of imaging a region in a patient, said method comprising administering a diagnostically effective amount of a compound of claim 1 in the form of micelles to the patient, exposing said region to radiation, and obtaining an image of said region by detecting said micelles of said compound.
Claim 18
Dependent Claim
12 words
A method of claim 16, wherein said region is the blood pool.
Claim 19
Dependent Claim
13 words
A method of claim 16, wherein said region is the liver or spleen.
Claim 20
Dependent Claim
12 words
A method of claim 16, wherein said region is the lymph nodes.
Claim 21
Dependent Claim
38 words
A radiographic imaging agent comprising a plurality of block copolymers forming a micelle, said block copolymers comprising a hydrophilic polymer linked to a hydrophobic polymer, and said hydrophobic polymer comprising a backbone incorporating radiopaque molecules via covalent bonds.
Claim 22
Dependent Claim
38 words
A radiographic imaging agent comprising a plurality of block copolymers forming a micelle, said block copolymers comprising a hydrophilic polymer linked to a hydrophobic polymer, and said hydrophobic polymer comprising a backbone incorporating radiopaque molecules via covalent bonds.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-22 | 2000-04-22 | 2000-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-22 | 2004-04-22 | 2004-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-22 | 2008-04-22 | 2008-10-22 | $7700.00 | Window Closed / Lapsed |