US5990194A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable in-situ forming implants and methods of producing the same
Assignee: Tolmar Therapeutics Inc
•
Filing: 1997-11-07
•
Granted: 1999-11-23
•
Expires: 2017-11-07
Abstract
Abstract A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
Inventors
- 👤 Richard L. Dunn
- 👤 James P. English
- 👤 Donald R. Cowsar
- 👤 David P. Vanderbilt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:08
CPC Classifications
A; A61; A61F; A61F2/00; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L15/62; A61L24/00; A61L24/001; A61L24/0015; A61L24/0026; A61L24/0042; A61L24/04; A61L24/046; A61L24/06; A61L26/00; A61L26/0009; A61L26/0019; A61L26/0061; A61L26/0066; A61L26/0076; A61L26/009; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/26; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L27/58; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2210/00; A61F2210/0004; A61F2210/0085; A61L2300/00; A61L2300/20; A61L2300/25; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/41; A61L2300/60; A61L2300/602; A61L2300/604; Y; Y10; Y10S; Y10S525/00; Y10S525/937
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
108 words
A method of adhering an implant to a patient's tissue, comprising: (a) applying a polymer system to the implant, the tissue, or both, wherein the polymer system comprises an effective amount of a water-insoluble biodegradable thermoplastic polymer and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) implanting the device in a human or animal wherein the polymer system forms a solid biodegradable matrix which adheres the implant to the tissue, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 2
Independent Claim
108 words
A method of adhering an implant to a patient's tissue, comprising: (a) applying a polymer system to the implant, the tissue, or both, wherein the polymer system comprises an effective amount of a water-insoluble biodegradable thermoplastic polymer and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) implanting the device in a human or animal wherein the polymer system forms a solid biodegradable matrix which adheres the implant to the tissue, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 3
Dependent Claim
14 words
The method of claim 1, wherein the polymer system further comprises a biologically-active agent.
Claim 4
Dependent Claim
48 words
The method of claim 1, wherein the thermoplastic polymer is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polydioxanones, polycarbonates, polyhydroxybutyrates, polyalkylene oxalates, polyanhydrides, polyamides, polyesteramides, polyurethanes, polyacetates, polyketals, polyorthocarbonates, polyphosphazenes, polyhydroxyvalerates, polyalkylene succinates, poly(malic acid), poly (amino acids), polyvinylpyrrolidone, polyethylene glycol, polyhydroxycellulose, polyorthoesters, and combinations thereof.
Claim 5
Dependent Claim
22 words
The method of claim 1, wherein the thermoplastic polymer is selected from the group consisting of polylactides, polycaprolactones and glycolide copolymers thereof.
Claim 6
Dependent Claim
40 words
The method of claim 1, wherein the solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, ethanol, propylene glycol, acetone, ethyl acetate, methyl acetate, methyl ethyl ketone, dimethylformamide, dimethyl sulfoxide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, 1-dodecylazacycloheptan-2-one, and combinations thereof.
Claim 7
Dependent Claim
23 words
The method of claim 1, wherein the solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, dimethyl sulfoxide, acetone, and combinations thereof.
Claim 8
Independent Claim
98 words
A method of encapsulating a prosthetic device, comprising: (a) applying a polymer system to the prosthetic device, wherein the polymer system comprises an effective amount of a water-insoluble biodegradable thermoplastic polymer, and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) implanting the prosthesis in a patient wherein the polymer system forms a solid biodegradable matrix that encapsulates the prosthetic device, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 9
Independent Claim
98 words
A method of encapsulating a prosthetic device, comprising: (a) applying a polymer system to the prosthetic device, wherein the polymer system comprises an effective amount of a water-insoluble biodegradable thermoplastic polymer, and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) implanting the prosthesis in a patient wherein the polymer system forms a solid biodegradable matrix that encapsulates the prosthetic device, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 10
Dependent Claim
14 words
The method of claim 7, wherein the polymer system further comprises a biologically-active agent.
Claim 11
Dependent Claim
48 words
The method of claim 7, wherein the thermoplastic polymer is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polydioxanones, polycarbonates, polyhydroxybutyrates, polyalkylene oxalates, polyanhydrides, polyamides, polyesteramides, polyurethanes, polyacetates, polyketals, polyorthocarbonates, polyphosphazenes, polyhydroxyvalerates, polyalkylene succinates, poly(malic acid), poly (amino acids), polyvinylpyrrolidone, polyethylene glycol, polyhydroxycellulose, polyorthoesters, and combinations thereof.
Claim 12
Dependent Claim
22 words
The method of claim 7, wherein the thermoplastic polymer is selected from the group consisting of polylactides, polycaprolactones and glycolide copolymers thereof.
Claim 13
Dependent Claim
40 words
The method of claim 7, wherein the solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, ethanol, propylene glycol, acetone, ethyl acetate, methyl acetate, methyl ethyl ketone, dimethylformamide, dimethyl sulfoxide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, 1-dodecylazacycloheptan-2-one, and combinations thereof.
Claim 14
Dependent Claim
23 words
The method of claim 7, wherein the solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, dimethyl sulfoxide acetone, and combinations thereof.
Claim 15
Dependent Claim
82 words
An implant comprising: (a) a polymer system comprising an effective amount of a water-insoluble biodegradable thermoplastic polymer and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) the implant wherein the polymer system forms a solid biodegradable matrix which adheres the implant to the tissue, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 16
Dependent Claim
82 words
An implant comprising: (a) a polymer system comprising an effective amount of a water-insoluble biodegradable thermoplastic polymer and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) the implant wherein the polymer system forms a solid biodegradable matrix which adheres the implant to the tissue, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 17
Dependent Claim
83 words
An encapsulated prosthetic device, comprising: (a) a polymer system comprising an effective amount of a water-insoluble biodegradable thermoplastic polymer, and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) a prosthetic device wherein the polymer system forms a solid biodegradable matrix that encapsulates the prosthetic device, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
Claim 18
Dependent Claim
83 words
An encapsulated prosthetic device, comprising: (a) a polymer system comprising an effective amount of a water-insoluble biodegradable thermoplastic polymer, and a biocompatible, water-soluble organic solvent which is capable of dissolving the thermoplastic polymer and capable of dissipating or diffusing into a body fluid; and (b) a prosthetic device wherein the polymer system forms a solid biodegradable matrix that encapsulates the prosthetic device, wherein the proportion of polymer in solvent and the polymer molecular weight are effective to provide said dissipating or diffusing function.
References Cited (Backward Citations)
US2155658A
Cited
US3068188A
Cited
US3328246A
Cited
US3218283A
Cited
US3219527A
Cited
US3463158A
Cited
US3520949A
Cited
US3887699A
Cited
US3767784A
Cited
US3760034A
Cited
FR2126270A1
Cited
US3755558A
Cited
US3696811A
Cited
US4450150A
Cited
US3939111A
Cited
US3935308A
Cited
US3931678A
Cited
US4161948A
Cited
US4148871A
Cited
US4408023A
Cited
US4715369A
Cited
US4793336A
Cited
US4447562A
Cited
US4582640A
Cited
US4570629A
Cited
US4677139A
Cited
US4491479A
Cited
US4439420A
Cited
US4443430A
Cited
US5286763A
Cited
US4631188A
Cited
WO1985000969A1
Cited
EP0140766A2
Cited
WO1985002092A1
Cited
EP0159293A1
Cited
US4663077A
Cited
US4745160A
Cited
CA1261549A
Cited
US4595713A
Cited
US4650665A
Cited
US4568536A
Cited
US4772470A
Cited
US4767627A
Cited
US4702917A
Cited
US4767861A
Cited
US4774227A
Cited
EP0241178A1
Cited
US4780320A
Cited
EP0244118A1
Cited
US4857602A
Cited
JPS63137907A
Cited
US4981696A
Cited
US4983689A
Cited
US5013553A
Cited
US4920203A
Cited
US5340849A
Cited
US4938763B1
Cited
US5739176A
Cited
US4938763A
Cited
US5278201A
Cited
US5278202A
Cited
US5324520A
Cited
US5007940A
Cited
US5324519A
Cited
US5368859A
Cited
US5077049A
Cited
EP0537559A1
Cited
EP0539751A1
Cited
EP0560014A1
Cited
EP0649662A1
Cited
US5707647A
Cited
US5717030A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-11-22 | 2003-05-24 | 2003-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-11-22 | 2007-05-24 | 2007-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-11-22 | 2011-05-24 | 2011-11-23 | $7700.00 | Window Closed / Lapsed |