EP0539751A1
Expired / Lapsed
EP
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Biodegradable polymer composition
Assignee: Tolmar Therapeutics Inc
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Filing: 1992-10-01
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Granted: —
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Expires: 2012-10-01
Abstract
Abstract The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
Inventors
- 👤 Richard L. Dunn
- 👤 Arthur J. Tipton
- 👤 George L. Southard
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:01
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L; A61L15/00; A61L15/07; A61L15/14; A61K31/00; A61K31/74; A61K33/00; A61K33/42; A61K47/00; A61K47/30; A61K47/34; A61K6/00; A61K6/50; A61K6/58; A61K9/0053; A61K9/0063; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/22; A61L27/227; A61L27/50; A61L27/54; A61L27/56; A61L27/58; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/14; A61L31/146; A61L31/148; A61L31/16; B; B29; B29C; B29C41/00; B29C41/02; B29C41/08; B29C41/12; B29C67/00; B29C67/02; B29C67/06; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/60; A61L2300/602; A61L2300/604
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
78 words
A composition suitable for forming an in situ solid implant in an animal, comprising: a liquid formulation of a biodegradable, bioerodible thermoplastic polymer that is substantially insoluble in aqueous or body fluid, and an organic solvent that is miscible or dispersible in aqueous or body fluid, the composition being capable of coagulating or solidifying to form a solid microporous matrix upon its contact with an aqueous or body fluid, the matrix being a core surrounded by a skin.
Claim 2
Dependent Claim
25 words
A composition according to claim 1, wherein the core is porous and the skin is substantially nonporous in comparison to the porosity of the core.
Claim 3
Dependent Claim
15 words
A composition according to claim 1, wherein the core and skin are both substantially porous.
Claim 4
Dependent Claim
11 words
A composition according to claim 1, further comprising a pore-forming agent.
Claim 5
Dependent Claim
28 words
A composition according to claim 4, wherein the pore-forming agent is a sugar, salt, or water-soluble polymer, or water-insoluble substance that rapidly degrades to a water soluble substance.
Claim 6
Dependent Claim
53 words
A composition according to claim 1, wherein the thermoplastic polymer is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamides, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates, polymalic acid, polyamino acids, polymethyl vinyl ether, chitin, chitosan, and copolymers, terpolymers, and any combination thereof.
Claim 7
Dependent Claim
52 words
A composition according to claim 1, wherein the solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, ethanol, propylene glycol, propylene carbonate, acetone, acetic acid, ethyl acetate, ethyl lactate, methyl acetate, methyl ethyl ketone, dimethylformamide, dimethyl sulfoxide, dimethyl sulfone, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, N,N-diethyl-m-toluamide, and 1-dodecylazacycloheptan-2-one, and any combination thereof.
Claim 8
Dependent Claim
13 words
A composition according to claim 1, further comprising at least one biologically-active agent.
Claim 9
Dependent Claim
25 words
A composition according to claim 8, wherein the biologically-active agent is a polypeptide or derivatives thereof derived from a natural, synthetic, or recombinant DNA source.
Claim 10
Dependent Claim
56 words
A composition according to claim 8, wherein the biologically-active agent is selected from a group consisting of anti-inflammatory agents, antibacterial agents, antiparasitic agents, antifungal agents, antiviral agents, anti-neoplastic agents, analgesic agents, anaesthetics, vaccines, central nervous system agents, growth factors, hormones, antihistamines, osteoinductive agents, cardiovascular agents, anti-ulcer agents, bronchodilators, vasodilators, birth control agents, and fertility enhancing agents.
Claim 11
Dependent Claim
42 words
A composition suitable for forming an in situ solid implant in an animal, comprising: a liquid formulation of a biodegradable, bioerodible thermoset polymer, the composition being capable of forming a solid microporous matrix, the matrix being a core surrounded by a skin.
Claim 12
Dependent Claim
25 words
A composition according to claim 11, wherein the core is porous and the skin is substantially nonporous in comparison to the porosity of the core.
Claim 13
Dependent Claim
15 words
A composition according to claim 11, wherein the core and skin are both substantially porous.
Claim 14
Dependent Claim
28 words
A composition according to claim 11 further comprising a pore-forming agent, an organic solvent that is miscible or dispersible in aqueous or body fluid or a combination thereof.
Claim 15
Dependent Claim
20 words
A composition according to claim 14 wherein the pore-forming agent is a sugar, salt, water-soluble polymer, or water-miscible organic solvent.
Claim 16
Dependent Claim
23 words
A composition according to claim 11, wherein the polymer is an acrylic ester-terminated biodegradable prepolymer capable of cross-linking to form a polymer matrix.
Claim 17
Dependent Claim
56 words
A composition according to claim 16, wherein the acrylic ester-terminated biodegradable prepolymer is selected from the group consisting essentially of polylactides, polyglycolides, polycaprolactones, polyanhydrides, polyamides, polyurethanes, polyesteramides, polyorthoesters, polydioxanones, polyacetals, polyketals, polycarbonates, polyorthocarbonates, polyphosphazenes, polyhydroxybutyrates, polyhydroxyvalerates, polyalkylene oxalates, polyalkylene succinates, polymalic acid, polyamino acids, polymethyl vinyl ether, chitin, chitosan, and copolymers, terpolymers, and any combination thereof.
Claim 18
Dependent Claim
11 words
A composition according to claim 11, further comprising a curing agent.
Claim 19
Dependent Claim
30 words
A composition according to claim 11, further comprising at least one biologically-active agent that is free of functional groups that would interfere with the thermosetting reaction of the thermoset polymer.
Claim 20
Dependent Claim
25 words
A composition according to claim 19, wherein the biologically-active agent is a polypeptide or derivatives thereof derived from a natural, synthetic, or recombinant DNA source.
Claim 21
Dependent Claim
56 words
A composition according to claim 19, wherein the biologically-active agent is selected from a group consisting of anti-inflammatory agents, antibacterial agents, antiparasitic agents, antifungal agents, antiviral agents, anti-neoplastic agents, analgesic agents, anaesthetics, vaccines, central nervous system agents, growth factors, hormones, antihistamines, osteoinductive agents, cardiovascular agents, anti-ulcer agents, bronchodilators, vasodilators, birth control agents and fertility enhancing agents.
Claim 22
Independent Claim
103 words
A method of forming an implant suitable for altering a biological or physiological activity in an animal, comprising: administering to the animal a composition in an amount effective to form in situ a solid implant, the composition being a liquid formulation of a biodegradable, bioerodible thermoplastic polymer that is substantially insoluble in aqueous or body fluid, and an organic solvent that is miscible or dispersible in aqueous or body fluid, and the composition undergoing coagulation or solidification of the polymer and dispersion of the solvent into body fluid to form a solid microporous matrix, the matrix being a core surrounded by a skin.
Claim 23
Dependent Claim
15 words
A method according to claim 22, wherein the implant is capable of enhancing tissue regeneration.
Claim 24
Dependent Claim
17 words
A method according to claim 22, wherein the implant is capable of filling in defects in tissue.
Claim 25
Dependent Claim
16 words
A method according to claim 22, wherein the composition further comprises at least one biologically-active agent.
Claim 26
Dependent Claim
57 words
A method according to claim 25, wherein the biologically active agent is selected from the group consisting of anti-inflammatory agents, antibacterial agents, antiparasitic agents, antifungal agents, antiviral agents, anti-neoplastic agents, analgesic agents, anaesthetics, vaccines, central nervous system agents, growth factors, hormones, antihistamines, osteoinductive agents, cardiovascular agents, anti-ulcer agents, vasodilators, bronchodilators, birth control agents, and fertility enhancing agents.
Claim 27
Dependent Claim
19 words
A method of claim 25, wherein the biologically-active agent alters the biological or physiological action of the reproductive system.
Claim 28
Independent Claim
74 words
A method of forming an implant suitable for altering a biological or physiological activity in an animal, comprising: administering to the animal a composition in an amount effective to form in situ a solid implant, the composition being a liquid formulation of a biodegradable, bioerodible thermoset polymer that is insoluble in aqueous or body fluid and the composition undergoing curing to form a microporous matrix, the matrix being a core surrounded by a skin.
References Cited (Backward Citations)
EP0430474A1
Cited
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