US5871535A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intralumenal drug eluting prosthesis
Assignee: Medtronic Inc
•
Filing: 1995-04-27
•
Granted: 1999-02-16
•
Expires: 2015-04-27
Abstract
Abstract A prosthesis for insertion into a lumen to limit restenosis of the lumen. The prosthesis carries restenosis-limiting drugs which elute after the device is positioned in the lumen.
Inventors
- 👤 Rodney G. Wolff
- 👤 Vincent W. Hull
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:16
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61F2/95; A61F2/958; A61L; A61L31/00; A61L31/14; A61L31/16; D; D04; D04C; D04C1/00; D04C1/02; A61F2/852; A61F2210/00; A61F2210/0076; A61F2250/00; A61F2250/0014; A61F2250/0048; A61F2250/0058; A61F2250/006; A61F2250/0063; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/416; D10; D10B; D10B2509/00; D10B2509/06
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
142 words
A method for administration of a drug to the interior of a body lumen comprising: (a) providing a catheter having mounted thereon a tubular, open-ended body including supporting elements and a preformed, flexible, polymeric element comprising at least one polymeric filament with an incorporated drug attached to the supporting elements and exposed at an exterior surface of the tubular body; (b) inserting the catheter and tubular body into the selected portion of a body lumen to be treated; (c) expanding the tubular body radially into contact with the wall of the selected portion of the body lumen such that a portion of the polymeric filament contacts the body lumen wall; and (d) removing the catheter from the body lumen such that the tubular body with supporting elements and polymeric filament remains in the body lumen in contact with the body lumen wall.
Claim 2
Independent Claim
142 words
A method for administration of a drug to the interior of a body lumen comprising: (a) providing a catheter having mounted thereon a tubular, open-ended body including supporting elements and a preformed, flexible, polymeric element comprising at least one polymeric filament with an incorporated drug attached to the supporting elements and exposed at an exterior surface of the tubular body; (b) inserting the catheter and tubular body into the selected portion of a body lumen to be treated; (c) expanding the tubular body radially into contact with the wall of the selected portion of the body lumen such that a portion of the polymeric filament contacts the body lumen wall; and (d) removing the catheter from the body lumen such that the tubular body with supporting elements and polymeric filament remains in the body lumen in contact with the body lumen wall.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the tubular body is radially expanded by a balloon.
Claim 4
Dependent Claim
32 words
The method of claim 1 wherein the tubular body is expanded radially by axially moving a first end of the tubular body with respect to a second end of the tubular body.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein the polymeric filament includes a bioabsorbable polymer.
Claim 6
Dependent Claim
24 words
The method of claim 4 wherein the bioabsorbable polymer is selected from the group consisting of polylactic acid, polyglycolic acid, polyanhydride, and polyphosphate ester.
Claim 7
Dependent Claim
13 words
The method of claim 1 wherein the polymeric filament includes a biostable polymer.
Claim 8
Dependent Claim
19 words
The method of claim 6 wherein the biostable polymer is selected from the group consisting of silicone and polyurethane.
Claim 9
Dependent Claim
13 words
The method of claim 1 wherein the incorporated drug is an antiplatelet drug.
Claim 10
Dependent Claim
13 words
The method of claim 1 wherein the incorporated drug is an anticoagulant drug.
Claim 11
Dependent Claim
21 words
The method of claim 9 wherein the anticoagulant drug is selected from the group consisting of heparin, coumadin, protamine and hirudin.
Claim 12
Dependent Claim
13 words
The method of claim 1 wherein the incorporated drug is an anti-replicate drug.
Claim 13
Dependent Claim
25 words
The method of claim 11 wherein the anti-replicate drug is selected from the group consisting of methotrexate, colchicine, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin.
Claim 14
Dependent Claim
13 words
The method of claim 1 wherein the incorporated drug is an anti-inflammatory drug.
Claim 15
Dependent Claim
12 words
The method of claim 13 wherein the anti-inflammatory drug is a glucocorticoid.
Claim 16
Dependent Claim
27 words
The method of claim 1 wherein the filament is adapted to release the incorporated drug in the body lumen over a period of 4 to 6 months.
Claim 17
Dependent Claim
20 words
The method of claim 1 wherein the filament is adapted to release the incorporated drug by elution of the drug.
Claim 18
Dependent Claim
21 words
The method of claim 1 wherein the filament is adapted to degrade in the body lumen to release the incorporated drug.
Claim 19
Dependent Claim
23 words
The method of claim 1 wherein the polymeric filament is attached to the supporting elements by weaving the filament into the supporting elements.
Claim 20
Dependent Claim
14 words
The method of claim 1 wherein a plurality of polymeric filaments are woven together.
Claim 21
Dependent Claim
15 words
The method of claim 1 wherein the polymeric filament is wound around the tubular body.
Claim 22
Dependent Claim
16 words
The method of claim 20 wherein the polymeric filament is helically wound around the tubular body.
Claim 23
Dependent Claim
25 words
The method of claim 1 wherein the bonding of the polymeric filament and the support structure is accomplished by bonding them together at a juncture.
Claim 24
Dependent Claim
15 words
The method of claim 22 wherein the bonding is accomplished by heating the polymeric filament.
Claim 25
Dependent Claim
13 words
The method of claim 1 wherein the polymeric filament includes multiple polymer layers.
Claim 26
Dependent Claim
19 words
The method of claim 24 wherein the polymeric filament includes a drug-containing inner layer and an outer barrier layer.
Claim 27
Dependent Claim
21 words
The method of claim 25 wherein the barrier layer includes a polymer selected from the group consisting of silicone and polyurethane.
Claim 28
Dependent Claim
33 words
The method of claim 1 also comprising the step of retaining the polymeric filament in contact with the luminal wall until tissue overgrowth causes the polymeric filament to grow into the luminal wall.
Claim 29
Independent Claim
129 words
A method for administration of a drug to the interior of a body lumen comprising: (a) providing a catheter having a stent mounted thereon and a preformed, flexible, polymeric element comprising at least one polymeric filament with an incorporated drug attached to the stent and exposed at an exterior surface of the stent; (b) inserting the catheter and stent into the selected portion of a body lumen to be treated; (c) expanding the stent radially into contact with the wall of the selected portion of the body lumen such that a portion of the polymeric filament contacts the body lumen wall; and (d) removing the catheter from the body lumen such that the stent with polymeric filament remains in the body lumen in contact with the body lumen wall.
Claim 30
Independent Claim
129 words
A method for administration of a drug to the interior of a body lumen comprising: (a) providing a catheter having a stent mounted thereon and a preformed, flexible, polymeric element comprising at least one polymeric filament with an incorporated drug attached to the stent and exposed at an exterior surface of the stent; (b) inserting the catheter and stent into the selected portion of a body lumen to be treated; (c) expanding the stent radially into contact with the wall of the selected portion of the body lumen such that a portion of the polymeric filament contacts the body lumen wall; and (d) removing the catheter from the body lumen such that the stent with polymeric filament remains in the body lumen in contact with the body lumen wall.
Claim 31
Dependent Claim
13 words
The method of claim 28 wherein the polymeric filament includes a biostable polymer.
Claim 32
Dependent Claim
19 words
The method of claim 29 wherein the biostable polymer is selected from the group consisting of silicone and polyurethane.
Claim 33
Dependent Claim
13 words
The method of claim 28 wherein the incorporated drug is an antiplatelet drug.
Claim 34
Dependent Claim
13 words
The method of claim 28 wherein the incorporated drug is an anticoagulant drug.
Claim 35
Dependent Claim
21 words
The method of claim 32 wherein the anticoagulant drug is selected from the group consisting of heparin, coumadin, protamine and hirudin.
Claim 36
Dependent Claim
13 words
The method of claim 28 wherein the incorporated drug is an anti-replicate drug.
Claim 37
Dependent Claim
25 words
The method of claim 34 wherein the anti-replicate drug is selected from the group consisting of methotrexate, colchicine, azathioprine, vincristine, vinblastine, fluorouracil, adriamycin, and mutamycin.
Claim 38
Dependent Claim
13 words
The method of claim 28 wherein the incorporated drug is an anti-inflammatory drug.
Claim 39
Dependent Claim
12 words
The method of claim 36 wherein the anti-inflammatory drug is a glucocorticoid.
Claim 40
Dependent Claim
27 words
The method of claim 28 wherein the filament is adapted to release the incorporated drug in the body lumen over a period of 4 to 6 months.
Claim 41
Dependent Claim
20 words
The method of claim 28 wherein the filament is adapted to release the incorporated drug by elution of the drug.
Claim 42
Dependent Claim
21 words
The method of claim 28 wherein the filament is adapted to degrade in the body lumen to release the incorporated drug.
Claim 43
Dependent Claim
21 words
The method of claim 28 wherein the polymeric filament is attached to the stent by weaving the filament into the stent.
Claim 44
Dependent Claim
14 words
The method of claim 28 wherein a plurality of polymeric filaments are woven together.
Claim 45
Dependent Claim
14 words
The method of claim 28 wherein the polymeric filament is wound onto the stent.
Claim 46
Dependent Claim
15 words
The method of claim 43 wherein the polymeric filament is helically wound onto the stent.
Claim 47
Dependent Claim
25 words
The method of claim 28 wherein the bonding of the polymeric filament and the support structure is accomplished by bonding them together at a juncture.
Claim 48
Dependent Claim
15 words
The method of claim 45 wherein the bonding is accomplished by heating the polymeric filament.
Claim 49
Dependent Claim
13 words
The method of claim 28 wherein the polymeric filament includes multiple polymer layers.
Claim 50
Dependent Claim
19 words
The method of claim 47 wherein the polymeric filament includes a drug-containing inner layer and an outer barrier layer.
Claim 51
Dependent Claim
21 words
The method of claim 48 wherein the barrier layer includes a polymer selected from the group consisting of silicone and polyurethane.
Claim 52
Dependent Claim
33 words
The method of claim 28 also comprising the step of retaining the polymeric filament in contact with the luminal wall until tissue overgrowth causes the polymeric filament to grow into the luminal wall.
References Cited (Backward Citations)
US4326532A
Cited
US4678466A
Cited
US4655771A
Cited
US4655771B1
Cited
GB2153235A
Cited
US4923470A
Cited
US4871365A
Cited
US4650466A
Cited
US4739762A
Cited
US4739762B1
Cited
US5102417A
Cited
US4944767A
Cited
US5028597A
Cited
US5061275A
Cited
US4872874A
Cited
US5059211A
Cited
US5047020A
Cited
WO1989003232A1
Cited
US4886062A
Cited
US4892539A
Cited
US5019096A
Cited
US5165919A
Cited
US5213580A
Cited
US5019090A
Cited
US5053048A
Cited
US5062829A
Cited
US5171262A
Cited
US5015253A
Cited
US5152783A
Cited
US5152784A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-15 | 2002-08-17 | 2003-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-15 | 2006-08-17 | 2007-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-15 | 2010-08-17 | 2011-02-16 | $7700.00 | Window Closed / Lapsed |