US5165919A
Expired / Lapsed
US
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Medical material containing covalently bound heparin and process for its production
Assignee: Asahi Kasei Medical Co Ltd
•
Filing: 1989-03-15
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Granted: 1992-11-24
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Expires: 2009-03-15
Abstract
Abstract A medical material comprising a high-molecular weight material and a heparin derivative is provided, which high-molecular weight material comprises a high-molecular weight compound having functional groups capable of binding with epoxy groups, a compound having at least two amino groups and a polymer having a number of epoxy groups, said functional groups and some of said amino groups being bound to said epoxy groups, and which heparin derivative comprises heparin and an epoxy compound having at least two epoxy groups part of which is bound to amino groups in the heparin, the amino groups not bound to the epoxy groups in said high-molecular weight material being bound to the epoxy groups not bound to the amino groups in the heparin derivative. Also provided are an intermediate (high-molecular weight material) to be used for said medical material, as well as processes for producing said medical material and said intermediate. This medical material retains the activity of heparin intact and has it bound strongly and in a large amount. Further, this medical material has good biocompatibility. The above-described intermediate and processes for production further enhance the characteristics of the above-described medical material.
Inventors
- 👤 Masatomi Sasaki
- 👤 Shinichi Kaneda
- 👤 Nobuyoshi Kashiwagi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:55
CPC Classifications
C; C08; C08L; C08L63/00; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; C08L63/06; Y; Y10; Y10S; Y10S623/00; Y10S623/924; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2938; Y10T428/31504; Y10T428/31511; Y10T428/31515; Y10T428/31536; Y10T428/31855; Y10T428/3188; Y10T428/31884; Y10T428/31909; Y10T428/31913; Y10T428/31917; Y10T428/3192
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
156 words
A medical material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component; said functional groups of the polymer (A) and some of said amino groups of the polymer (D) have reacted with the epoxy groups of the polymer (B); said heparin derivative (F) comprises heparin and a polymer (H) having two glycidyl groups per one polymer chain; some of the epoxy groups of said polymer (H) have reacted with amino groups int he heparin; and the amino groups remaining unreacted in said high-molecular weight material (E) have reacted with the epoxy groups remaining unreacted in the heparin derivative (F).
Claim 2
Dependent Claim
156 words
A medical material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component; said functional groups of the polymer (A) and some of said amino groups of the polymer (D) have reacted with the epoxy groups of the polymer (B); said heparin derivative (F) comprises heparin and a polymer (H) having two glycidyl groups per one polymer chain; some of the epoxy groups of said polymer (H) have reacted with amino groups int he heparin; and the amino groups remaining unreacted in said high-molecular weight material (E) have reacted with the epoxy groups remaining unreacted in the heparin derivative (F).
Claim 3
Dependent Claim
24 words
A medical material according to claim 1, wherein the polymer (B) having epoxy groups has at least three epoxy groups per unit chain length.
Claim 4
Dependent Claim
15 words
A medical material according to claim 1, wherein the polymer (D) is polyethyleneimine or polyacrylamide.
Claim 5
Dependent Claim
14 words
A medical material according to claim 1, wherein polymer (H) is polyethyleneglycol diglycidyl ether.
Claim 6
Dependent Claim
152 words
A process for producing the medical material of claim 1, which comprises reacting unreacted epoxy groups of a heparin derivative (F) with unreacted amino groups of a high-molecular weight material (E) in an aqueous solution, wherein said heparin derivative (F) comprises heparin and a polymer (H) having two diglycidyl groups per one polymer chain; some of the epoxy groups of said polymer (H) have reacted with amino groups in the heparin; said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different form polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component; and the functional groups of the polymer (A) and some of the amino groups of the polymer (D) have reacted with the epoxy groups of the polymer (B).
Claim 7
Dependent Claim
23 words
A process according to claim 5 wherein the epoxy group containing polymer (B) has at least three epoxy groups per unit chain length.
Claim 8
Dependent Claim
14 words
A process according to claim 5, wherein the polymer (D) is polyethyleneimine or polyacrylamide.
Claim 9
Dependent Claim
13 words
A process according to claim 6, wherein polymer (H) is polyethyleneglycol diglycidyl ether.
Claim 10
Dependent Claim
156 words
An antithrombotic material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component; said functional groups of the polymer (A) and some of the amino groups of the polymer (D) have reacted with the epoxy groups of the polymer (B); said heparin derivative (F) comprises heparin and a polymer (H) having two glycidyl groups per one polymer chain; some of the epoxy groups of said polymer (H) have reacted with amino groups in the heparin; and the amino groups remaining unreacted in said high-molecular weight material (E) have reacted with the epoxy groups remaining unreacted in the heparin derivative (F).
Claim 11
Dependent Claim
156 words
An antithrombotic material which comprises a high-molecular weight material (E) and a heparin derivative (F), wherein said high-molecular weight material (E) comprises a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups, a polymer (D), different from polymer A, having at least two amino groups and an epoxy group containing polymer (B) having a vinyl monomer as an essential component; said functional groups of the polymer (A) and some of the amino groups of the polymer (D) have reacted with the epoxy groups of the polymer (B); said heparin derivative (F) comprises heparin and a polymer (H) having two glycidyl groups per one polymer chain; some of the epoxy groups of said polymer (H) have reacted with amino groups in the heparin; and the amino groups remaining unreacted in said high-molecular weight material (E) have reacted with the epoxy groups remaining unreacted in the heparin derivative (F).
Claim 12
Dependent Claim
24 words
An antithrombotic material according to claim 9, wherein the epoxy group containing polymer (B) has at least three epoxy groups per unit chain length.
Claim 13
Dependent Claim
15 words
An antithrombotic material according to claim 9, wherein the polymer (D) is polyethyleneimine or polyacrylamide.
Claim 14
Dependent Claim
14 words
An antithrombotic material according to claim 9, wherein polymer (H) is polyethyleneglycol diglycidyl ether.
Claim 15
Dependent Claim
129 words
A medical material obtained by reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein the high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
Claim 16
Dependent Claim
129 words
A medical material obtained by reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein the high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
Claim 17
Dependent Claim
24 words
A medical material according to claim 13, wherein the epoxy group containing polymer (B) has at least three epoxy groups per unit chain length.
Claim 18
Dependent Claim
15 words
A medical material according to claim 13, wherein the polymer (D) is polyethyleneimine or polyacrylamide.
Claim 19
Dependent Claim
14 words
A medical material according to claim 13, wherein polymer (H) is polyethyleneglycol diglycidyl ether.
Claim 20
Dependent Claim
133 words
A process for producing a medical material, which comprises reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein said high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
Claim 21
Dependent Claim
133 words
A process for producing a medical material, which comprises reacting unreacted amino groups of a high-molecular weight material (E) with unreacted epoxy groups of a heparin derivative (F), wherein said high-molecular weight material (E) is obtained by reacting a reaction product containing unreacted epoxy groups which is obtained by reacting a polymer (A) having functional groups selected from the group consisting of hydroxyl groups, amino groups and carboxyl groups with an epoxy group containing polymer (B) having a vinyl monomer as an essential component, with a polymer (D), different from polymer A, having at least two amino groups, and wherein said heparin derivative (F) is obtained by reacting heparin with a polymer (H) having two diglycidyl groups per one polymer chain wherein some of the epoxy groups of the polymer (H) remain unreacted.
Claim 22
Dependent Claim
23 words
A process according to claim 17, wherein the epoxy group containing polymer (B) has at least three epoxy groups per unit chain length.
Claim 23
Dependent Claim
14 words
A process according to claim 17, wherein the polymer (D) is polyethyleneimine or polyacrylamide.
Claim 24
Dependent Claim
13 words
A process according to claim 17, wherein polymer (H) is polyethyleneglycol diglycidyl ether.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-24 | 1996-05-25 | 1996-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-24 | 2000-05-25 | 2000-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-24 | 2004-05-25 | 2004-11-24 | $7700.00 | Window Closed / Lapsed |