US5735897A — Intravascular stent pump

Claim 1

Independent Claim 113 words

An implantable device constructed and arranged in a laminate structure comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer of a matrix material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, wherein said device upon implantation has a predetermined outer diameter selected to correspond substantially with an inner diameter of an implant site, whereby when the device is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable matrix material.

Claim 2

Dependent Claim 113 words

An implantable device constructed and arranged in a laminate structure comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer of a matrix material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, wherein said device upon implantation has a predetermined outer diameter selected to correspond substantially with an inner diameter of an implant site, whereby when the device is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable matrix material.

Claim 3

Dependent Claim 16 words

The device of claim 1 wherein the first and second layers are comprised of polymeric material.

Claim 4

Dependent Claim 27 words

The device of claim 2 wherein the polymeric material is selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof.

Claim 5

Dependent Claim 10 words

The device of claim 1 in a cylindrical, stent-like configuration.

Claim 6

Dependent Claim 20 words

The device of claim 1 wherein at least one of the first and second layers is comprised of polymeric material.

Claim 7

Dependent Claim 48 words

The device of claim 1 wherein the intermediate layer is made of a material selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide or polyvinyl alcohol, said intermediate layer being made up in an aqueous solution containing the dissolved drug or therapeutic to be contained therein.

Claim 8

Dependent Claim 39 words

A device as in claim 1 wherein the first and second spaced layers are each comprised of a curable and resorbable material and the intermediate third layer and the drug or therapeutic contained in the intermediate layer are resorbable.

Claim 9

Dependent Claim 93 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate matrix layer of blood-swellable material, the matrix layer containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable matrix material, said device upon implantation having a predetermined outer diameter selected to correspond substantially with an inner diameter of an implant site.

Claim 10

Dependent Claim 93 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate matrix layer of blood-swellable material, the matrix layer containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable matrix material, said device upon implantation having a predetermined outer diameter selected to correspond substantially with an inner diameter of an implant site.

Claim 11

Dependent Claim 19 words

The device of claim 8 wherein the inner and outer layers of support material are comprised of polymeric material.

Claim 12

Dependent Claim 20 words

The device of claim 8 wherein at least one of the inner and outer layers is comprised of polymeric material.

Claim 13

Dependent Claim 35 words

The device of claim 10 wherein the at least one polymeric layer is made of a polymeric material selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof.

Claim 14

Dependent Claim 41 words

The device of claim 8 wherein the outer layer is comprised of a polymer, a reactive monomer and a polymerization initiator; the intermediate layer is comprised of a swellable drug-bearing layer, and the inner layer is comprised of a porous material.

Claim 15

Dependent Claim 155 words

The device of claim 8 wherein: a) the outer layer is comprised of a polymeric material selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof, a reactive monomer and a polymerization initiator; b) the intermediate layer is comprised of a swellable drug-bearing layer made of a material selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide or polyvinyl alcohol, said intermediate layer being made up in an aqueous solution containing the dissolved drug or therapeutic to be contained therein; and c) the inner layer is a porous polymeric material comprising a polymer selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof, a reactive monomer, a polymerization initiator and a component selected from the group consisting of microcrystalline salts, simple inorganic salts, sugars, polysaccharides or mixtures thereof in an effective amount to impart porosity to said inner layer.

Claim 16

Dependent Claim 27 words

A device as in claim 8 wherein the inner and outer binding layers are curable and resorbable and the intermediate matrix layer containing therapeutic materials is resorbable.

Claim 17

Dependent Claim 109 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: a) an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and additionally including microcrystalline sodium heparin; b) an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone; and c) an intermediate matrix layer of blood-swellable material, the matrix layer containing therapeutic materials to be dispersed into the blood, said intermediate matrix layer being comprised of polyvinylpyrrolidone, water and sodium heparin.

Claim 18

Dependent Claim 109 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: a) an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and additionally including microcrystalline sodium heparin; b) an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone; and c) an intermediate matrix layer of blood-swellable material, the matrix layer containing therapeutic materials to be dispersed into the blood, said intermediate matrix layer being comprised of polyvinylpyrrolidone, water and sodium heparin.

Claim 19

Dependent Claim 131 words

An implantable device constructed and arranged in a laminate structure, the device comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer of a matrix material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, wherein said device has a first outer diameter prior to implantation in a body and a second outer diameter after implantation, and the outer diameter of the device after implantation corresponds substantially with an inner diameter of an implant site, whereby when the device is implanted in a body, the drug or therapeutic is pumped into the implant site in response to the swelling of the fluid-swellable matrix material.

Claim 20

Dependent Claim 131 words

An implantable device constructed and arranged in a laminate structure, the device comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer of a matrix material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, wherein said device has a first outer diameter prior to implantation in a body and a second outer diameter after implantation, and the outer diameter of the device after implantation corresponds substantially with an inner diameter of an implant site, whereby when the device is implanted in a body, the drug or therapeutic is pumped into the implant site in response to the swelling of the fluid-swellable matrix material.

Claim 21

Dependent Claim 110 words

An implantable device having a generally cylindrical form constructed and arranged for fluid flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate matrix layer of fluid-swellable material, the matrix layer containing therapeutic materials to be dispersed into an implant site in a body in response to the swelling of the fluid-swellable matrix material, said device having a first outer diameter prior to implantation, and a second outer diameter after implantation, the outer diameter of the device after implantation corresponds substantially with an inner diameter of the implant site.

Claim 22

Dependent Claim 110 words

An implantable device having a generally cylindrical form constructed and arranged for fluid flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate matrix layer of fluid-swellable material, the matrix layer containing therapeutic materials to be dispersed into an implant site in a body in response to the swelling of the fluid-swellable matrix material, said device having a first outer diameter prior to implantation, and a second outer diameter after implantation, the outer diameter of the device after implantation corresponds substantially with an inner diameter of the implant site.

Claim 23

Dependent Claim 117 words

An implantable device constructed and arranged in a laminate structure, comprising: first and second spaced layers of support material comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, at least one of which is fluid permeable and is further comprised of microcrystalline sodium heparin, an intermediate third of a matrix material having fluid-swellable characteristics, said intermediate layer being comprised of polyvinylpyrrolidone water and sodium heparin, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, whereby when the device is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable matrix material.

Claim 24

Dependent Claim 117 words

An implantable device constructed and arranged in a laminate structure, comprising: first and second spaced layers of support material comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, at least one of which is fluid permeable and is further comprised of microcrystalline sodium heparin, an intermediate third of a matrix material having fluid-swellable characteristics, said intermediate layer being comprised of polyvinylpyrrolidone water and sodium heparin, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, whereby when the device is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable matrix material.

Claim 25

Dependent Claim 111 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, and microcrystalline sodium heparin; an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1propanone, and an intermediate matrix layer of blood-swellable material, the matrix layer being comprised of polyvinylpyrrolidone, water and sodium heparin and further containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable matrix material.

Claim 26

Dependent Claim 111 words

An implantable intravascular device having a generally cylindrical form constructed and arranged for blood flow therethrough, said device comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, and microcrystalline sodium heparin; an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1propanone, and an intermediate matrix layer of blood-swellable material, the matrix layer being comprised of polyvinylpyrrolidone, water and sodium heparin and further containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable matrix material.

Claim 27

Dependent Claim 118 words

An implantable stent comprising: a) first and second spaced layers of support material, at least one of said layers being fluid permeable; b) an intermediate third layer of a material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, said first, second and third layers being constructed and arranged in a laminate structure; and c) a drug or therapeutic contained in the intermediate layer, wherein said stent upon implantation has an outer diameter adapted to fit an inner diameter of an implant site, whereby when the stent is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable material.

Claim 28

Dependent Claim 118 words

An implantable stent comprising: a) first and second spaced layers of support material, at least one of said layers being fluid permeable; b) an intermediate third layer of a material having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, said first, second and third layers being constructed and arranged in a laminate structure; and c) a drug or therapeutic contained in the intermediate layer, wherein said stent upon implantation has an outer diameter adapted to fit an inner diameter of an implant site, whereby when the stent is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable material.

Claim 29

Dependent Claim 16 words

The implantable stent of claim 20 adapted to be expanded in situ to fit the vessel.

Claim 30

Dependent Claim 12 words

The implantable stent of claim 21 wherein the stent is balloon expandable.

Claim 31

Dependent Claim 11 words

The implantable stent of claim 21 wherein the stent is self-expanding.

Claim 32

Dependent Claim 21 words

The implantable stent of claim 20 wherein at least one of the first and second layers is comprised of polymeric material.

Claim 33

Dependent Claim 17 words

The implantable stent of claim 24 wherein the first and second layers are comprised of polymeric material.

Claim 34

Dependent Claim 28 words

The implantable stent of claim 24 wherein the polymeric material is selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides, and mixtures thereof.

Claim 35

Dependent Claim 49 words

The implantable stem of claim 20 wherein the intermediate layer is made of a material selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide or polyvinyl alcohol, said intermediate layer being made up in an aqueous solution containing the dissolved drug or therapeutic to be contained therein.

Claim 36

Dependent Claim 39 words

A implantable stent of claim 26 wherein the first and second spaced layers are each comprised of a curable and resorbable material and the intermediate third layer and the drug or therapeutic contained in the intermediate layer are resorbable.

Claim 37

Dependent Claim 86 words

An implantable intravascular stent having a generally cylindrical form adapted for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate layer of blood-swellable material, the intermediate layer containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable material, said stent upon implantation having an outer diameter adapted to fit an inner diameter of an implant site.

Claim 38

Dependent Claim 86 words

An implantable intravascular stent having a generally cylindrical form adapted for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate layer of blood-swellable material, the intermediate layer containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable material, said stent upon implantation having an outer diameter adapted to fit an inner diameter of an implant site.

Claim 39

Dependent Claim 14 words

The stent of claim 29 adapted to be expanded to fit the implant site.

Claim 40

Dependent Claim 9 words

The stent of claim 30 which is balloon expandable.

Claim 41

Dependent Claim 8 words

The stent of claim 30 which is self-expanding.

Claim 42

Dependent Claim 19 words

The stent of claim 29 wherein the inner and outer layers of support material are comprised of polymeric material.

Claim 43

Dependent Claim 20 words

The stent of claim 29 wherein at least one of the inner and outer layers is comprised of polymeric material.

Claim 44

Dependent Claim 35 words

The stent of claim 34 wherein the at least one polymeric layer is made of a polymeric material selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof.

Claim 45

Dependent Claim 155 words

The stent of claim 29 wherein: a) the outer layer is comprised of a polymeric material selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof, a reactive monomer and a polymerization initiator; b) the intermediate layer is comprised of a swellable drug-bearing layer made of a material selected from the group consisting of polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide or polyvinyl alcohol, said intermediate layer being made up in an aqueous solution containing the dissolved drug or therapeutic to be contained therein; and c) the inner layer is a porous polymeric material comprising a polymer selected from the group consisting of polylactics, polyacetates, polyacrylates, polyglycol, polycaprolactones, polyesters, polyethers, polyamides and mixtures thereof, a reactive monomer, a polymerization initiator and a component selected from the group consisting of microcrystalline salts, simple inorganic salts, sugars, polysaccharides or mixtures thereof in an effective amount to impart porosity to said inner layer.

Claim 46

Dependent Claim 27 words

A stent as in claim 29 wherein the inner and outer binding layers are curable and resorbable and the intermediate matrix layer containing therapeutic materials is resorbable.

Claim 47

Dependent Claim 41 words

The stent of claim 29 wherein the outer layer is comprised of a polymer, a reactive monomer and a polymerization initiator; the intermediate layer is comprised of a swellable drug-bearing layer, and the inner layer is comprised of a porous material.

Claim 48

Dependent Claim 107 words

An implantable intravascular stent having a generally cylindrical form constructed and arranged for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: a) an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and additionally including microcrystalline sodium heparin; b) an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone; and c) an intermediate layer of blood-swellable material, the intermediate layer containing therapeutic materials to be dispersed into the blood, said intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin.

Claim 49

Dependent Claim 107 words

An implantable intravascular stent having a generally cylindrical form constructed and arranged for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: a) an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and additionally including microcrystalline sodium heparin; b) an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone; and c) an intermediate layer of blood-swellable material, the intermediate layer containing therapeutic materials to be dispersed into the blood, said intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin.

Claim 50

Dependent Claim 14 words

The stent of claim 39 adapted to be expanded to fit the implant site.

Claim 51

Dependent Claim 10 words

The stent of claim 40, said stent being balloon expandable.

Claim 52

Dependent Claim 9 words

The stent of claim 40, said stent being self-expanding.

Claim 53

Dependent Claim 120 words

An implantable stent comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate third layer, wherein said stent has a first outer diameter prior to implantation in a body and a second outer diameter after implantation, and the outer diameter of the stent after implantation corresponds substantially with an inner diameter of an implant site, whereby when the stent is implanted in a body, the drug or therapeutic is pumped into the implant site in response to the swelling of the fluid-swellable intermediate third layer.

Claim 54

Dependent Claim 120 words

An implantable stent comprising: first and second spaced layers of support material, at least one of said layers being fluid permeable, an intermediate third layer having fluid-swellable characteristics, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate third layer, wherein said stent has a first outer diameter prior to implantation in a body and a second outer diameter after implantation, and the outer diameter of the stent after implantation corresponds substantially with an inner diameter of an implant site, whereby when the stent is implanted in a body, the drug or therapeutic is pumped into the implant site in response to the swelling of the fluid-swellable intermediate third layer.

Claim 55

Dependent Claim 14 words

The stent of claim 43 adapted to be expanded to fit the implant site.

Claim 56

Dependent Claim 9 words

The stent of claim 44 which is balloon expandable.

Claim 57

Dependent Claim 8 words

The stent of claim 45 which is self-expanding.

Claim 58

Dependent Claim 109 words

An implantable stent having a generally cylindrical form and being adapted for fluid flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate layer of fluid-swellable material, the intermediate layer containing therapeutic materials to be dispersed into an implant site in a body in response to the swelling of the fluid-swellable material, said stent having a first outer diameter prior to implantation, and a second outer diameter after implantation, wherein the outer diameter of the stent after implantation corresponds substantially with an inner diameter of the implant site.

Claim 59

Dependent Claim 109 words

An implantable stent having a generally cylindrical form and being adapted for fluid flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material; an outer binding layer of support material, and an intermediate layer of fluid-swellable material, the intermediate layer containing therapeutic materials to be dispersed into an implant site in a body in response to the swelling of the fluid-swellable material, said stent having a first outer diameter prior to implantation, and a second outer diameter after implantation, wherein the outer diameter of the stent after implantation corresponds substantially with an inner diameter of the implant site.

Claim 60

Dependent Claim 14 words

The stent of claim 47 adapted to be expanded to fit the implant site.

Claim 61

Dependent Claim 9 words

The stent of claim 48 which is balloon expandable.

Claim 62

Dependent Claim 8 words

The stent of claim 48 which is self-expanding.

Claim 63

Dependent Claim 106 words

An implantable stent comprising: first and second spaced layers of support material comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, at least one of which is fluid permeable and is further comprised of microcrystalline sodium heparin, an intermediate third layer having fluid-swellable characteristics, said intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, whereby when the stent is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable material.

Claim 64

Dependent Claim 106 words

An implantable stent comprising: first and second spaced layers of support material comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, at least one of which is fluid permeable and is further comprised of microcrystalline sodium heparin, an intermediate third layer having fluid-swellable characteristics, said intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin, the intermediate layer being held between the first and second layers, and a drug or therapeutic contained in the intermediate layer, whereby when the stent is implanted in a vessel in a body, the drug or therapeutic is pumped into the vessel in response to the swelling of the fluid-swellable material.

Claim 65

Dependent Claim 14 words

The stent of claim 51 adapted to be expanded to fit the implant site.

Claim 66

Dependent Claim 9 words

The stent of claim 52 which is balloon expandable.

Claim 67

Dependent Claim 8 words

The stent of claim 52 which is self-expanding.

Claim 68

Dependent Claim 107 words

An implantable intravascular stent having a generally cylindrical form adapted for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, and microcrystalline sodium heparin; an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and an intermediate layer of blood-swellable material, the intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin and further containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable material.

Claim 69

Dependent Claim 107 words

An implantable intravascular stent having a generally cylindrical form adapted for blood flow therethrough, said stent comprising a multi-layer wall, said wall comprising at least: an inner binding layer of permeable support material, said inner layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, and microcrystalline sodium heparin; an outer binding layer of support material, said outer layer being comprised of poly-D,L-lactic acid, ethylene glycol dimethacrylate and 2-hydroxy-2-methyl-1-phenyl-1-propanone, and an intermediate layer of blood-swellable material, the intermediate layer being comprised of polyvinylpyrrolidone, water and sodium heparin and further containing therapeutic materials to be dispersed into the blood in response to the swelling of the blood-swellable material.

Claim 70

Dependent Claim 14 words

The stent of claim 55 adapted to be expanded to fit the implant site.

Claim 71

Dependent Claim 9 words

The stent of claim 56 which is balloon expandable.

Claim 72

Dependent Claim 8 words

The stent of claim 56 which is self-expanding.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2001-04-06	2001-10-06	2002-04-07	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2005-04-06	2005-10-06	2006-04-07	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2009-04-06	2009-10-06	2010-04-07	$7700.00	Window Closed / Lapsed

Intravascular stent pump

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