Patent US5693034A successfully refreshed from Google Patents.
US5693034A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Lubricous polymer network
Assignee: Boston Scientific Scimed Inc
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Filing: 1995-06-02
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Granted: 1997-12-02
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Expires: 2015-06-02
Abstract
Abstract A polymer network useful as a lubricous coating, the polymer network comprising a reaction product of a vinyl prepolymer and an uncrosslinked hydrogel retained within the reaction product such that the network exhibits a greater lubricity when wet.
Inventors
- 👤 Paul J. Buscemi
- 👤 Paul C. Slaikeu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:55
CPC Classifications
C; C08; C08L; C08L33/00; C08L33/04; C08L33/06; A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; C09; C09D; C09D133/00; C09D133/04; C09D133/06; C08L2205/00; C08L2205/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
137 words
An angioplasty catheter including a composition coating the distal end of said catheter, the composition comprising: the reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acrylates, styrene, and divinyl benzene said monomers being polymerizable to form a crosslinked polymer that adheres to the surface of the device and resists degradation from rubbing and hydration; a polymerization initiator; and an uncrosslinked linear, water-soluble, hydrophilic hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacryate, said hydrogel being intertwined with the polymer so as to prevent the hydrogel from leaching out of the coating composition, the hydrogel being lubricous when wet and substantially unnoticeable on the surface when dry, and said monomers being polymerized in the presence of the hydrogel; and a solvent.
Claim 2
Dependent Claim
137 words
An angioplasty catheter including a composition coating the distal end of said catheter, the composition comprising: the reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acrylates, styrene, and divinyl benzene said monomers being polymerizable to form a crosslinked polymer that adheres to the surface of the device and resists degradation from rubbing and hydration; a polymerization initiator; and an uncrosslinked linear, water-soluble, hydrophilic hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacryate, said hydrogel being intertwined with the polymer so as to prevent the hydrogel from leaching out of the coating composition, the hydrogel being lubricous when wet and substantially unnoticeable on the surface when dry, and said monomers being polymerized in the presence of the hydrogel; and a solvent.
Claim 3
Dependent Claim
132 words
An angioplasty catheter including a drug delivery system coating the distal end of said catheter, said drug delivery system comprising: a reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acylates, styrene and divinyl benzene, said monomers being polymerizable to form a crosslinked polymer that is adherent to a substrate on a medical device and resistant to degradation from rubbing and hydration; with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethyene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polypyrrolidone and 2-hydroxyethyl methyacrylate which is lubricous where wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel; and a drug miscible in water, and leachable from the coating.
Claim 4
Dependent Claim
132 words
An angioplasty catheter including a drug delivery system coating the distal end of said catheter, said drug delivery system comprising: a reaction product of vinyl monomers selected from the group consisting of mono-, di- and tri-acylates, styrene and divinyl benzene, said monomers being polymerizable to form a crosslinked polymer that is adherent to a substrate on a medical device and resistant to degradation from rubbing and hydration; with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethyene oxide, polyacrylic acid, polyacrylamide, poly (sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polypyrrolidone and 2-hydroxyethyl methyacrylate which is lubricous where wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel; and a drug miscible in water, and leachable from the coating.
Claim 5
Dependent Claim
134 words
A catheter for insertion into a human body, the catheter comprising: (a) a shaft having a proximal and a distal and a lumen extending from proximal end to the distal end, wherein the distal end will be inserted into the human body, and (b) a polymer network disposed on a surface of the shit, the polymer network comprising a polymer formed by reacting of a vinyl monomer selected from the group consisting of mono-, di, and tri-acylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
Claim 6
Dependent Claim
134 words
A catheter for insertion into a human body, the catheter comprising: (a) a shaft having a proximal and a distal and a lumen extending from proximal end to the distal end, wherein the distal end will be inserted into the human body, and (b) a polymer network disposed on a surface of the shit, the polymer network comprising a polymer formed by reacting of a vinyl monomer selected from the group consisting of mono-, di, and tri-acylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
Claim 7
Dependent Claim
23 words
The catheter of claim 3 further comprising a guide wire lumen, having a proximal end and a distal end, disposed within the shaft.
Claim 8
Dependent Claim
50 words
The catheter of claim 4 further comprising a balloon having a proximal end and a distal end, the proximal end of the balloon being secured to the distal end of the shaft and the distal end of the balloon being secured to the distal end of the guide wire lumen.
Claim 9
Dependent Claim
14 words
The catheter of claim 5 wherein the polymer network is disposed on the balloon.
Claim 10
Dependent Claim
127 words
A medical device for insertion into a human body, the device comprising: (a) an elongate member having a proximal end and a distal end, wherein the distal end will be inserted into the human body, and (b) a polymer network disposed on a surface of the elongate member, the polymer network comprising a polymer formed by reacting a vinyl monomer selected from the group consisting of mono-, di- and tri-acrylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
Claim 11
Dependent Claim
127 words
A medical device for insertion into a human body, the device comprising: (a) an elongate member having a proximal end and a distal end, wherein the distal end will be inserted into the human body, and (b) a polymer network disposed on a surface of the elongate member, the polymer network comprising a polymer formed by reacting a vinyl monomer selected from the group consisting of mono-, di- and tri-acrylates, styrene and divinyl benzene, with an uncrosslinked linear, hydrophilic, water-soluble hydrogel selected from the group consisting of polyethylene oxide, polyacrylic acid, polyacrylamide, poly(sodium-4-styrenesulfonate), poly(3-hydroxybutyric acid), polyvinylpyrrolidone and 2-hydroxyethyl methacrylate which is lubricous when wet and substantially-unnoticeable on the substrate when dry and retained within the reaction product, said monomers being polymerized in the presence of the hydrogel.
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