US5545213A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for administering a bioactive agent
Assignee: Medtronic Inc
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Filing: 1995-04-27
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Granted: 1996-08-13
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Expires: 2015-04-27
Abstract
Abstract Articles having a graft polymer with a net ionic charge bonded to a polymeric substrate surface provide an improved method for administering a bioactive agent having a net ionic charge. The [articles are] method is especially useful [as] for thromboresistant and/or antimicrobial medical devices.
Inventors
- 👤 James R. Keogh
- 👤 Christopher M. Hobot
- 👤 John W. Eaton
- 👤 Allan H. Jevne
- 👤 Matthew A. Bergan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:04
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/204; A61L2300/206; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/42; A61L2300/442; A61L2300/60; A61L2300/602; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
147 words
A method for administering a bioactive agent having a net ionic charge to a patient comprising the steps of: (a) providing an implantable article having a polymeric surface; (b) preparing an aqueous solution comprising as a first monomer, a water soluble monomer which includes pendant groups selected from the group consisting of amine groups and acid groups, said groups capable of imparting a net ionic charge in a graft polymer, and as a second monomer, a neutral, hydrophilic monomer; (c) contacting the polymeric surface of the implantable article with the monomer solution for a period of time effective to provide a copolymer of the first and second monomers grafted to the surface, said copolymer having a net ionic charge; (d) placing the bioactive agent having a net charge onto the grafted surface; and (e) implanting the article and bioactive agent into the patient's body in blood contact.
Claim 2
Independent Claim
147 words
A method for administering a bioactive agent having a net ionic charge to a patient comprising the steps of: (a) providing an implantable article having a polymeric surface; (b) preparing an aqueous solution comprising as a first monomer, a water soluble monomer which includes pendant groups selected from the group consisting of amine groups and acid groups, said groups capable of imparting a net ionic charge in a graft polymer, and as a second monomer, a neutral, hydrophilic monomer; (c) contacting the polymeric surface of the implantable article with the monomer solution for a period of time effective to provide a copolymer of the first and second monomers grafted to the surface, said copolymer having a net ionic charge; (d) placing the bioactive agent having a net charge onto the grafted surface; and (e) implanting the article and bioactive agent into the patient's body in blood contact.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the bioactive agent has the same net charge as the graft copolymer.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the graft copolymer has a net (+) charge and the bioactive agent has a net (-) charge.
Claim 5
Dependent Claim
23 words
The method of claim 1 wherein the graft copolymer has a net (-) charge and the bioactive agent has a net (+) charge.
Claim 6
Dependent Claim
25 words
The method of claim 1 wherein the first monomer is selected from the group consisting of acrylic acid, 2-acrylamido-2-methylpropane sulfonic acid, and N-(3-aminopropyl) methacrylamide hydrochloride.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein the second monomer is acrylamide.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the bioactive agent is a cationic antimicrobial compound.
Claim 9
Dependent Claim
27 words
The method of claim 7 wherein the cationic antimicrobial compound is selected from the group consisting of gentamycin, kanamycin, neomycin, silver ion, chlorhexidine, vancomycin, streptomycin and erythromycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-13 | 2000-02-12 | 2000-08-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-13 | 2004-02-12 | 2004-08-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-13 | 2008-02-12 | 2008-08-13 | $7700.00 | Window Closed / Lapsed |