US5344455A
Expired / Lapsed
US
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Graft polymer articles having bioactive surfaces
Assignee: Medtronic Inc
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Filing: 1992-10-30
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Granted: 1994-09-06
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Expires: 2012-10-30
Abstract
Abstract Articles comprised of bioactive agents coupled to or repelled by a graft polymer (made, for example, from monomers such as N-(3-aminopropyl) methacrylamide hydrochloride (APMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm)m and acrylic acid (AA)) which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.
Inventors
- 👤 James R. Keogh
- 👤 Christopher M. Hobot
- 👤 John W. Eaton
- 👤 Allan H. Jevne
- 👤 Matthew A. Bergan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:19
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/204; A61L2300/206; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/42; A61L2300/442; A61L2300/60; A61L2300/602; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
121 words
An article for use in contact with blood or blood products, the article including at least one biocompatible polymeric surface for contacting blood or blood products, the polymeric surface having thereon a first layer and a second layer, the first layer comprising a graft co-polymer grafted onto the polymeric surface by co-polymerizing a first vinyl monomer selected from the group consisting of 2-acrylamido-2-methylpropane sulfonic acid, acrylamide, acrylic acid, and 2-hydroxyethyl methacrylate with a second vinyl monomer of N-(3-aminopropyl) methacrylamide hydrochloride which provides the graft co-polymer with pendant primary amine groups, the second layer comprising a bioactive agent selected from the group consisting of antibiotics, antimicrobials, anticoagulants and albumin-binding dyes coupled to the graft co-polymer by coupling to its primary amine groups.
Claim 2
Dependent Claim
121 words
An article for use in contact with blood or blood products, the article including at least one biocompatible polymeric surface for contacting blood or blood products, the polymeric surface having thereon a first layer and a second layer, the first layer comprising a graft co-polymer grafted onto the polymeric surface by co-polymerizing a first vinyl monomer selected from the group consisting of 2-acrylamido-2-methylpropane sulfonic acid, acrylamide, acrylic acid, and 2-hydroxyethyl methacrylate with a second vinyl monomer of N-(3-aminopropyl) methacrylamide hydrochloride which provides the graft co-polymer with pendant primary amine groups, the second layer comprising a bioactive agent selected from the group consisting of antibiotics, antimicrobials, anticoagulants and albumin-binding dyes coupled to the graft co-polymer by coupling to its primary amine groups.
Claim 3
Dependent Claim
16 words
The article of claim 1 wherein the bioactive agent is ionically coupled to the graft co-polymer.
Claim 4
Dependent Claim
16 words
The article of claim 1 wherein the bioactive agent is covalently coupled to the graft co-polymer.
Claim 5
Dependent Claim
12 words
The article of claim 1 wherein the bioactive agent is an antibiotic.
Claim 6
Dependent Claim
11 words
The article of claim 1 wherein the polymeric surface is polyurethane.
Claim 7
Dependent Claim
11 words
The article of claim 1 wherein the polymeric surface is polyetherurethane.
Claim 8
Dependent Claim
18 words
The article of claim 1 wherein the graft copolymer includes 2-acrylamido-2-methylpropane sulfonic acid as the first vinyl monomer.
Claim 9
Dependent Claim
11 words
The article of claim 1 wherein the bioactive agent is gentamycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-05 | 1998-03-07 | 1998-09-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-05 | 2002-03-07 | 2002-09-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-05 | 2006-03-07 | 2006-09-06 | $7700.00 | Window Closed / Lapsed |