EP0419275A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Flowable demineralized bone powder composition and its use in bone repair
Assignee: Osteotech Inc
•
Filing: 1990-09-21
•
Granted: —
•
Expires: 2010-09-21
Abstract
Abstract A flowable demineralized bone powder composition is provided for use in surgical bone repair.
Inventors
- 👤 Robert K. O'leary
- 👤 Patrick A. Mcbrayer
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 00:41
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/686; A61B17/82; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/2803; A61F2/2846; A61F2/30; A61F2/46; A61F2/4644; A61K; A61K35/00; A61K35/12; A61K35/32; A61L24/00; A61L24/0005; A61L27/14; A61L27/22; A61L27/227; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61F2/44; A61F2/4455; A61F2002/2817; A61F2002/2835; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30075; A61F2002/30108; A61F2002/30199; A61F2002/302; A61F2002/30224; A61F2002/30235; A61F2002/30261; A61F2210/00; A61F2210/0061; A61F2230/00; A61F2230/0063; A61F2230/0065; A61F2230/0069; A61F2230/0082; A61L2400/00; A61L2400/06; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
69 words
A flowable composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth-inducing amount of demineralized osteogenic bone powder in a biocompatible carrier, the carrier being selected from a member of the group consisting of liquid polyhydroxy compound, liquid polyhydroxy compound derivative, liquid solution of solid polyhydroxy compound, liquid solution of solid polyhydroxy compound derivative and mixtures thereof.
Claim 2
Dependent Claim
69 words
A flowable composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth-inducing amount of demineralized osteogenic bone powder in a biocompatible carrier, the carrier being selected from a member of the group consisting of liquid polyhydroxy compound, liquid polyhydroxy compound derivative, liquid solution of solid polyhydroxy compound, liquid solution of solid polyhydroxy compound derivative and mixtures thereof.
Claim 3
Dependent Claim
21 words
The composition of Claim 1 wherein the carrier is selected from the group consisting of glycerol, glycerol monoester and glycerol diester.
Claim 4
Dependent Claim
27 words
The composition of Claim 1 wherein the carrier is selected from the group consisting of monosaccharide, monosaccharide derivative, disaccharide, disaccharide derivative, oligosaccharide, oligosaccharide derivative and mixtures thereof.
Claim 5
Dependent Claim
20 words
The composition of Claim 1 wherein the carrier is selected from the group consisting of fructose, glucose and mixtures thereof.
Claim 6
Dependent Claim
14 words
The composition of Claim 1 wherein the carrier is a liquid solution of sucrose.
Claim 7
Dependent Claim
14 words
The composition of Claim 1 wherein the carrier is an aqueous solution of sucrose.
Claim 8
Dependent Claim
19 words
The composition of Claim 1 wherein the carrier is a liquid solution of a fatty acid monoester of glycerol.
Claim 9
Dependent Claim
27 words
The composition of Claim 1 wherein the carrier is a fatty acid monoester dissolved in a solvent which is a different liquid polyhydroxy compound and/or derivative thereof.
Claim 10
Dependent Claim
34 words
The composition of Claim 1 wherein the carrier is a fatty acid monoester dissolved in a solvent selected from the group consisting of propylene glycol, glycerol, monoacetin, diacetin, liquid polyethylene glycol and mixtures thereof.
Claim 11
Dependent Claim
15 words
The composition of Claim 1 wherein the carrier is glycerol monolaurate dissolved in a solvent.
Claim 12
Dependent Claim
25 words
The composition of Claim 1 wherein the carrier is glycerol monolaurate dissolved in a solvent which is a different liquid polyhydroxy compound and/or derivative thereof.
Claim 13
Dependent Claim
32 words
The composition of Claim 1 wherein the carrier is glyceryl monolaurate dissolved in a solvent selected from the group consisting of propylene glycol, glycerol, monoacetin, diacetin, liquid polyethylene glycol and mixtures thereof.
Claim 14
Dependent Claim
22 words
The composition of Claim 1 wherein the average particle size of the demineralized bone powder is from about 0.1 to about 1.2cm.
Claim 15
Dependent Claim
22 words
The composition of Claim 1 wherein the average particle size of the demineralized bone powder is from about 0.2 to about 1cm.
Claim 16
Dependent Claim
24 words
The composition of Claim 1 wherein the demineralized bone powder is derived from cortical bone, cancellous and/or corticocancellous autogenous, xenogenic and/or allogenic bone tissue.
Claim 17
Dependent Claim
27 words
The composition of Claim 1 containing from about 5 to about 90 weight percent demineralized bone powder and from about 10 to about 95 weight percent carrier.
Claim 18
Dependent Claim
27 words
The composition of Claim 1 containing from about 20 to about 80 weight percent demineralized bone powder and from about 20 to about 80 weight percent carrier.
Claim 19
Dependent Claim
80 words
The composition of Claim 1 containing at least one additional ingredient selected from the group consisting of antiviral agent, antimicrobial agent, antibiotic agent, amino acid, peptide, vitamin, inorganic element, protein synthesis co-factor, hormone, endocrine tissue, synthesizer, enzyme, polymer-cell scaffolding agent with parenchymal cells, angiogenic drug, polymeric drug carrier, collagen lattice, antigenic agent, cytoskeletal agent, mesenchymal stem cells, bone digester, antitumor agent, cellular attractant, fibronectin, growth hormone cellular attachment agent, immunosuppressant, nucleic acid, surface active agent, hydroxy apatite and penetration enhancer.
Claim 20
Dependent Claim
9 words
The composition of Claim 1 containing a bioerodable polymer.
References Cited (Backward Citations)
EP0082621A1
Cited
US4440750A
Cited
US4563489A
Cited
GB2175807A
Cited
WO1986007265A1
Cited
WO1989004646A1
Cited
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.