US5437287A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sterilization of tissue implants using iodine
Assignee: Carbomedics Inc
•
Filing: 1992-08-17
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Granted: 1995-08-01
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Expires: 2012-08-17
Abstract
Abstract The present invention provides an iodine-based solution, and a method of using that solution, which sterilizes tissue implants without denaturing the proteins in the implant and without inducing calcification of the implant in vivo. Preferably, the tissue implants sterilized using the present invention are fixed without using glutaraldehyde. Most preferably, the tissue implants are fixed by photooxidation.
Inventors
- 👤 Richard E. Phillips
- 👤 Mark A. Moore
- 👤 Ruth L. Russell
- 👤 David Cheung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:36
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61L2/00; A61L2/16; A61L2/18; A61L27/3687; A61L2103/00; A61L2103/05; Y; Y10; Y10S; Y10S623/00; Y10S623/92
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
70 words
A method for sterilizing a medical device intended for implantation inside the body of a mammal comprising the steps of: providing an implant comprised at least in part of excised proteinaceous tissue; and incubating said implant in a germicidal solution comprising elemental iodine at a concentration, a temperature, and for a time effective to sterilize said implant without damaging said implant, said germicidal solution having a pH between about 5.0-6.8.
Claim 2
Independent Claim
70 words
A method for sterilizing a medical device intended for implantation inside the body of a mammal comprising the steps of: providing an implant comprised at least in part of excised proteinaceous tissue; and incubating said implant in a germicidal solution comprising elemental iodine at a concentration, a temperature, and for a time effective to sterilize said implant without damaging said implant, said germicidal solution having a pH between about 5.0-6.8.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein said germicidal solution further comprises iodine stabilizing salts.
Claim 4
Dependent Claim
16 words
The method of claim 2 wherein said iodine stabilizing salts are potassium iodide and sodium iodide.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein said elemental iodine comprises about 0.01% to 0.20% by weight of said solution.
Claim 6
Dependent Claim
19 words
The method of claim 2 wherein said elemental iodine comprises about 0.01% to 0.20% by weight of said solution.
Claim 7
Dependent Claim
19 words
The method of claim 3 wherein said elemental iodine comprises about 0.01% to 0.20% by weight of said solution.
Claim 8
Dependent Claim
23 words
The method of claim 3 wherein said potassium iodide and sodium iodide each comprise about 0.01% to 0.40% by weight of said solution.
Claim 9
Dependent Claim
25 words
The method of claim 7 wherein said elemental iodine, potassium iodide, and sodium iodide each comprise about 0.09% to 0.11% by weight of said solution.
Claim 10
Dependent Claim
14 words
The method of claim 8 wherein said pH is between about 6.4 to 6.6.
Claim 11
Dependent Claim
30 words
The method of claim 1 wherein said time of exposure is between about three hours and two weeks and said incubation temperature is between about 20° C. and 50° C.
Claim 12
Dependent Claim
26 words
The method of claim 9 wherein said time of exposure is about two days and said incubation temperature is between about 35° C. and 39° C.
Claim 13
Dependent Claim
28 words
The method of claim 9 where said time of exposure comprises two twenty-four hour stages wherein said iodine solution is refreshed after a first twenty four hour stage.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-07-31 | 1999-01-30 | 1999-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-07-31 | 2003-01-30 | 2003-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-07-31 | 2007-01-30 | 2007-08-01 | $7700.00 | Window Closed / Lapsed |