US4120649A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Transplants
Assignee: Individual
•
Filing: 1976-03-29
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Granted: 1978-10-17
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Expires: 1996-03-29
Abstract
Abstract Transplants, particularly from pigskin, from humans, and amniotic membranes of newborns are prepared from the appropriate tissue -- which tissue is treated with the compound glutaraldehyde (GA). The so treated tissue excels by favorable biological function: increased resistance to infection, markedly reduced antigenicity, and prolonged retention time on the recipient, as well as the possibility to store so treated tissue for a prolonged span of time.
Inventors
- 👤 Israel Schechter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:04
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687; A61K; A61K35/00; A61K35/12; A61K35/36; A61K35/44; A61L27/50; A61L27/60; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
79 words
A process for diminishing the antigenicity of tissues derived from one species when used as a transplant in a different species, for rendering such tissues substantially resistant to infection, and for rendering such tissues liable to be stored for a prolonged period of time, comprising: treating the tissue in a solution of glutaraldehyde in an aqueous solvent of suitable pH; and transplanting the treated tissue into an animal species different than that from which the original tissue was derived.
Claim 2
Dependent Claim
79 words
A process for diminishing the antigenicity of tissues derived from one species when used as a transplant in a different species, for rendering such tissues substantially resistant to infection, and for rendering such tissues liable to be stored for a prolonged period of time, comprising: treating the tissue in a solution of glutaraldehyde in an aqueous solvent of suitable pH; and transplanting the treated tissue into an animal species different than that from which the original tissue was derived.
Claim 3
Dependent Claim
21 words
The process according to claim 1, wherein said treating step is effected in a 0.3 to 5.0 percent solution of glutaraldehyde.
Claim 4
Dependent Claim
17 words
The process according to claim 2, wherein said treating step is effected during 7 to 20 minutes.
Claim 5
Dependent Claim
30 words
The process according to claim 1, further including the step of washing the tissue after said treating step and before said transplanting step so as to remove any free glutaraldehyde.
Claim 6
Dependent Claim
42 words
The process according to claim 1, further including the step of washing the tissue after said treating step and before said transplanting step with a suitable amino acid, amine or other nucleophile to block any free functional groups of the bound glutaraldehyde.
Claim 7
Dependent Claim
19 words
The process according to claim 5, wherein said suitable amino acid, amine or other nucleophile is a suitable amine.
Claim 8
Dependent Claim
35 words
The process according to claim 1, further including the step of treating the tissue, after treatment with glutaraldehyde and before said transplanting step, with an agent adapted to modify the surface properties of the tissue.
Claim 9
Dependent Claim
23 words
The process according to claim 7, wherein said agent is adapted to attach negative or positive charges to the surface of the tissue.
Claim 10
Dependent Claim
21 words
The process according to claim 7, wherein said agent is adapted to attach hydrophobic moieties to the surface of the tissue.
Claim 11
Dependent Claim
20 words
The process according to claim 1, wherein the tissue used is skin and said transplanting step is a skin graft.
Claim 12
Dependent Claim
13 words
The process according to claim 1, wherein the tissue is a blood vessel.
Claim 13
Dependent Claim
26 words
A process according to claim 1, wherein the treated tissue is transplanted into a human and was derived from an animal species other than a human.
Claim 14
Dependent Claim
21 words
A process according to claim 1, wherein the treated tissue is pig skin, and said transplanting step is a skin graft.
Claim 15
Dependent Claim
60 words
A process for diminishing the antigenicity of tissues intended for use as transplants, for rendering such tissues substantially resistant to infection, and for rendering such tissues liable to be stored for prolonged periods of time, comprising: treating the tissue in a solution of glutaraldehyde in an aqueous solvent of suitable pH; and transplanting the treated tissue into a human patient.
Claim 16
Dependent Claim
60 words
A process for diminishing the antigenicity of tissues intended for use as transplants, for rendering such tissues substantially resistant to infection, and for rendering such tissues liable to be stored for prolonged periods of time, comprising: treating the tissue in a solution of glutaraldehyde in an aqueous solvent of suitable pH; and transplanting the treated tissue into a human patient.
Claim 17
Dependent Claim
14 words
A process according to claim 14, wherein the tissue is derived from a human.
Claim 18
Dependent Claim
16 words
The process according to claim 15, wherein the tissue is an amniotic membrane of a newborn.
Claim 19
Dependent Claim
18 words
A process according to claim 14, wherein the tissue is derived from an animal species other than human.
Claim 20
Dependent Claim
20 words
A process according to claim 17, wherein the tissue is pig skin, and said transplanting step is a skin graft.
Claim 21
Dependent Claim
34 words
A process according to claim 14, further including, after said glutaraldehyde treating step and prior to said transplanting step, the step of: treating the glutaraldehyde treated tissue with an aqueous solution including glutamic acid.
Claim 22
Dependent Claim
13 words
A process according to claim 19, wherein the tissue is a blood vessel.
Claim 23
Dependent Claim
28 words
A process according to claim 20, wherein said transplanting step comprises transplanting said treated blood vessel as a substitute for a damaged blood vessel in the human patient.
Claim 24
Dependent Claim
12 words
A process according to claim 7, wherein said agent is glutamic acid.
Claim 25
Dependent Claim
16 words
A process according to claim 1, wherein said suitable pH is from about 4 to 12.
Claim 26
Dependent Claim
36 words
A process according to claim 1, further including, after said glutaraldehyde treating step and prior to said transplanting step, the step of: storing the glutaraldehyde treated tissue in a transplant bank for prolonged periods of time.
Claim 27
Dependent Claim
36 words
A process according to claim 14, further including, after said gluaraldehyde treating step and prior to said transplanting step, the step of: storing the glutaraldehyde treated tissue in a transplant bank for prolonged periods of time.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-16 | 1982-04-17 | 1982-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-16 | 1986-04-17 | 1986-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-16 | 1990-04-17 | 1990-10-17 | $7700.00 | Window Closed / Lapsed |