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US5162114A
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US
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Bone collagen matrix for xenogenic implants
Assignee: Stryker Corp
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Filing: 1990-11-21
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Granted: 1992-11-10
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Expires: 2010-11-21
Abstract
Abstract Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area and porosity. The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can be used as a surface coat around implantable prosthetic devices to promote cellular ingrowth or as a carrier for sustained release of various therapeutic compositions.
Inventors
- 👤 Thangavel Kuberasampath
- 👤 Richard J. Ridge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/24; A61L27/28; A61L27/34; A61L27/36; A61L27/3604; A61L27/3608; A61L27/50; A61L27/56; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A61C; A61C8/00; A61C8/0003; A61C8/0004; A61C8/0006; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K38/00; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
71 words
A matrix for implantation in a mammalian host comprising: a) biodegradable, biocompatible, mineral-free Type-I insoluble bone collagen particles, xenogenic to said host and having intraparticle pores, said particles being depleted in noncollagenous protein, having a mean diameter within the range of 70 μm to 850 μm, and an intraparticle surface area greater than the surface are of native demineralized bone powder, and b) an osteogenic protein adsorbed onto a surface thereof.
Claim 2
Dependent Claim
71 words
A matrix for implantation in a mammalian host comprising: a) biodegradable, biocompatible, mineral-free Type-I insoluble bone collagen particles, xenogenic to said host and having intraparticle pores, said particles being depleted in noncollagenous protein, having a mean diameter within the range of 70 μm to 850 μm, and an intraparticle surface area greater than the surface are of native demineralized bone powder, and b) an osteogenic protein adsorbed onto a surface thereof.
Claim 3
Dependent Claim
78 words
A matrix for implantation in a mammalian host comprising: a) biodegradable, biocompatible, mineral-free Type-I insoluble bone collagen particles, xenogenic to said host and having intraparticle pores, said particles being depleted in noncollagenous protein, having a mean diameter within the range of 70 μm to 850 μm, and an intraparticle surface area greater than the surface area of native demineralized bone powder, and b) a therapeutic drug adsorbed onto a surface thereof for sustained release in said mammalian host.
Claim 4
Dependent Claim
78 words
A matrix for implantation in a mammalian host comprising: a) biodegradable, biocompatible, mineral-free Type-I insoluble bone collagen particles, xenogenic to said host and having intraparticle pores, said particles being depleted in noncollagenous protein, having a mean diameter within the range of 70 μm to 850 μm, and an intraparticle surface area greater than the surface area of native demineralized bone powder, and b) a therapeutic drug adsorbed onto a surface thereof for sustained release in said mammalian host.
Claim 5
Dependent Claim
10 words
The matrix of claim 1, or 2 comprising packed particles.
Claim 6
Dependent Claim
21 words
The matrix of claim 3 wherein said particles have a mean diameter within the range of 150 μm to 420 μm.
Claim 7
Dependent Claim
10 words
The matrix of claim 3 wherein said particles are deglycosylated.
Claim 8
Dependent Claim
27 words
The matrix of claim 3 wherein the particles define interstices dimensioned to permit influx, proliferation and differentiation of migratory cells from the body of said mammalian host.
Claim 9
Dependent Claim
19 words
The matrix of claim 3 wherein said matrix is shaped to span a non-union fracture in said mammalian host.
Claim 10
Dependent Claim
21 words
The matrix of claim 3 wherein said particles are incubated with a swelling agent followed by washing to remove soluble components.
Claim 11
Dependent Claim
14 words
The matrix of claim 8 wherein said swelling agent is an organic protein denaturant.
Claim 12
Dependent Claim
11 words
The matrix of claim 8 wherein said swelling agent is dichloromethane.
Claim 13
Dependent Claim
12 words
The matrix of claim 8 wherein said swelling agent is hydrogen fluoride.
Claim 14
Dependent Claim
12 words
The matrix of claim 8 wherein said swelling agent is trifluoroacetic acid.
Claim 15
Dependent Claim
19 words
The matrix of claim 8 wherein said swelling agent is dichloromethane, acetonitrile, or isopropanol mixed with 0.1%-10% trifluoroacetic acid.
Claim 16
Dependent Claim
11 words
The matrix of claim 8 wherein said swelling agent is isopropanol.
Claim 17
Dependent Claim
11 words
The matrix of claim 8 wherein said swelling agent is acetonitrile.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |