US5000957A — Dispenser comprising hydrophilic osmopolymer

Claim 1

Independent Claim 163 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) wall means that surrounds and defines an internal compartment, said wall means comprising at least in part a composition permeable to the passage of fluid present in the environment of use; (b) thermoplastic means in the compartment for absorbing thermal energy from the environment of use for dispensing a beneficial agent; (c) a beneficial agent present in the thermoplastic means for absorbing thermal energy for dispensing the beneficial agent; (d) a hydrophilic osmopolymer in the compartment for expanding, occupying an increasing area of the compartment, and for pushing the thermoplastic means from the compartment; (e) lamina means for enhancing the amount of beneficial agent delivered from the dispensing device in the compartment positioned between the thermoplastic means and the hydrophilic osmopolymer; and (f) exit means in the wall for releasing the beneficial agent from the dispensing device to the environment of use over time.

Claim 2

Dependent Claim 163 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing device comprising: (a) wall means that surrounds and defines an internal compartment, said wall means comprising at least in part a composition permeable to the passage of fluid present in the environment of use; (b) thermoplastic means in the compartment for absorbing thermal energy from the environment of use for dispensing a beneficial agent; (c) a beneficial agent present in the thermoplastic means for absorbing thermal energy for dispensing the beneficial agent; (d) a hydrophilic osmopolymer in the compartment for expanding, occupying an increasing area of the compartment, and for pushing the thermoplastic means from the compartment; (e) lamina means for enhancing the amount of beneficial agent delivered from the dispensing device in the compartment positioned between the thermoplastic means and the hydrophilic osmopolymer; and (f) exit means in the wall for releasing the beneficial agent from the dispensing device to the environment of use over time.

Claim 3

Dependent Claim 25 words

The dispensing device for delivery the beneficial agent formulation to the environment of use according to claim 1, wherein the hydrophilic osmopolymer comprises an osmagent.

Claim 4

Dependent Claim 31 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means comprises in at least a part a semipermeable composition.

Claim 5

Dependent Claim 35 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the exit means in the wall for delivering the beneficial agent comprises at least one passageway.

Claim 6

Dependent Claim 41 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the exit means in the wall for delivering the beneficial agent comprises at least one passageway formed in the environment of use.

Claim 7

Dependent Claim 38 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means that surrounds and defines the compartment comprises in at least a part a microporous polymer member.

Claim 8

Dependent Claim 38 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means that surrounds and defines the compartment comprises in at least a part an impermeable polymer member.

Claim 9

Dependent Claim 50 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the exit means in the wall for delivering the beneficial agent from the device comprises a passageway forming material that is removed therefrom by fluid present in the environment of use.

Claim 10

Dependent Claim 33 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means comprises a microporus member laminated in part to a semipermeable member.

Claim 11

Dependent Claim 33 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the thermoplastic means form a dispensable composition at a temperature greater than 25° C.

Claim 12

Dependent Claim 60 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means comprises a member selected from the group consisting of a cellulose ester, cellulose diester, cellulose triester, cellulose ether, cellulose ester-ether, cellulose acylate, cellulose diacylate, cellusose triacylate, cellulose acetate, cellulose acetate butyrate, cellulose propionate morphilinobutyrate, and cellulose aetate phthalate.

Claim 13

Dependent Claim 64 words

The dispensing device for delivering the beneficial agent formulation to the environment of use according to claim 1, wherein the wall means comprises a member selected from the group consisting of a cellulose ester, cellulose diester, cellulose triester, cellulose ether, cellulose ester-ether, cellulose acylate, cellulose diacylate, cellusose triacylate, cellulose acetate, cellulose acetate butyrate, cellulose propionate morphilinobutyrate, and cellulose aetate phthalate, and a pore former.

Claim 14

Dependent Claim 152 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing system comprising: (a) a hollow body member having an internal lumen; (b) a thermoplastic heat-sensitive beneficial agent formulation in the lumen that forms a deliverable formulation at a temperature of at least 25° C.; (c) hydrogel means in the lumen for expanding from a first size to an increased size; (f) laminar means in the lumen for lessening the mixing of the thermoplastic means with hydrogel means, said laminar means positioned between the thermoplastic means and the hydrogel means; (e) a wall surrounding the hollow body, the wall comprising in at least a part a composition that is permeable to the passage of fluid; and, (f) at least one passageway means in the wall communicating with the lumen for delivering the formulation to the environment of use at a controlled rate over a prolonged period of

Claim 15

Dependent Claim 152 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the dispensing system comprising: (a) a hollow body member having an internal lumen; (b) a thermoplastic heat-sensitive beneficial agent formulation in the lumen that forms a deliverable formulation at a temperature of at least 25° C.; (c) hydrogel means in the lumen for expanding from a first size to an increased size; (f) laminar means in the lumen for lessening the mixing of the thermoplastic means with hydrogel means, said laminar means positioned between the thermoplastic means and the hydrogel means; (e) a wall surrounding the hollow body, the wall comprising in at least a part a composition that is permeable to the passage of fluid; and, (f) at least one passageway means in the wall communicating with the lumen for delivering the formulation to the environment of use at a controlled rate over a prolonged period of

Claim 16

Dependent Claim 186 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the delivering system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising in at least in part a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent; (b) means in the lumen for maintaining the delivery system in the environment of use over time, said means having a density of at least 1.2; (c) hydrogel means in the lumen for expanding and occupying an increased volume of the lumen; (d) a heat-sensitive means in the lumen that forms a dispensable carrier at a temperature greater than 25° C.; (e) a beneficial agent present in the heat-sensitive means; (f) lamina means in the lumen between the hydrogel means and the heat-sensitive means, said lamina means positioned there between for lessening the migration of beneficial agent from the heat-sensitive means into the hydrogen means; and, (g) exit means in the wall for communicating with the lumen for delivering the beneficial agent to the environment of use over time.

Claim 17

Dependent Claim 186 words

A dispensing device for delivering a beneficial agent formulation to an environment of use, the delivering system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising in at least in part a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent; (b) means in the lumen for maintaining the delivery system in the environment of use over time, said means having a density of at least 1.2; (c) hydrogel means in the lumen for expanding and occupying an increased volume of the lumen; (d) a heat-sensitive means in the lumen that forms a dispensable carrier at a temperature greater than 25° C.; (e) a beneficial agent present in the heat-sensitive means; (f) lamina means in the lumen between the hydrogel means and the heat-sensitive means, said lamina means positioned there between for lessening the migration of beneficial agent from the heat-sensitive means into the hydrogen means; and, (g) exit means in the wall for communicating with the lumen for delivering the beneficial agent to the environment of use over time.

Claim 18

Dependent Claim 20 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the beneficial agent formulation is avermectin.

Claim 19

Dependent Claim 20 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the beneficial agent formulation comprises ivermectin.

Claim 20

Dependent Claim 31 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the heat-sensitive beneficial agent formulation comprises a block copolymer comprising 1,2-butylene oxide and ethylene oxide and ivermectin.

Claim 21

Dependent Claim 24 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the heat-sensitive means comprises a food grade wax and ivermectin.

Claim 22

Dependent Claim 27 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the hydrogel means comprises a sodium salt of polyacrylic acid and sodium chloride.

Claim 23

Dependent Claim 23 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the wall comprises cellulose acetate butyrate and polyethylene glycol.

Claim 24

Dependent Claim 47 words

The delivery system for delivering a beneficial agent formulation according to claim 14, wherein the means for maintaining the delivery system in the environment of use comprises a member selected from the group consisting of iron, steel, iron magnesium alloy, and a mixture of cobalt and iron.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1994-03-18	1994-09-17	1995-03-19	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1998-03-18	1998-09-17	1999-03-19	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2002-03-18	2002-09-17	2003-03-19	$7700.00	Window Closed / Lapsed

Dispenser comprising hydrophilic osmopolymer

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag