US4642230A — Release device

Claim 1

Independent Claim 88 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically active material and being degradable when the bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 2

Dependent Claim 88 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically active material and being degradable when the bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 3

Dependent Claim 19 words

A release device as set forth in claim 1 wherein said outer segments are tubular segments of inert material.

Claim 4

Dependent Claim 23 words

A release device as set forth in claim 2 wherein said outer segments seal relative to one another by abutting against one another.

Claim 5

Dependent Claim 22 words

A release device as set forth in claim 3 further including a sealing washer between each adjacent pair of said outer segments.

Claim 6

Dependent Claim 19 words

A release device according to claim 1 wherein said biologically active material is Lasalocid comprising the formula 3-methyl-6-[7-ethyl-4-hydroxy-3,5-dimethyl-6-oxo-7-[5-ethyl-3-methyl-5-(5-ethyl-5-hydroxy-6-methyl-2-tetrahydropyranyl)-2-tetrahydrofuryl}heptyl]-salicyclic acid.

Claim 7

Dependent Claim 23 words

A release device as set forth in claim 1 wherein said biologically-active material is M139603 comprising the chemical structure of 2,3,4,5-tetrahydro-3-[(2S)-2-{(1S,2R,6S)--6-[(E)-2-}(2R,3R,6S)-6-[(E)-2-}(2R,3R,6S)-3,4,5,6-tetrahydro-6-{(3S,E-3-{(2R,3S,5R)-2,3,4,5-tetrahydro-5-[(1S)-1-methoxyethyl]-3-methylfur-2-yl}-but-1-enyl}-3-methyl-2H-pyran-2-yl{-3-hyroxyprop-1-enyl]-2-methylcyclohexyl}propionyl]furan-2,4-dione, sodium salt).

Claim 8

Dependent Claim 93 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a unitary rod-form core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically active material and being degradable when said bolus is exposed to a liquid environment to release said material into said environment, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 9

Dependent Claim 93 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a unitary rod-form core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically active material and being degradable when said bolus is exposed to a liquid environment to release said material into said environment, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 10

Dependent Claim 95 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a plurality of spaced-apart circular inner segments of biologically active material and being degradable when said bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 11

Dependent Claim 95 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a plurality of spaced-apart circular inner segments of biologically active material and being degradable when said bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 12

Dependent Claim 129 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a plurality of spaced-apart annular inner segments of biologically active material penetrated by a rod, said inner segments and said rod being degradable when said bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments each having a respective flange extending inwardly to said rod thereby to space apart a respective pair of said inner segments, said outer segments being arranged to be shed from the bolus as said core is progressively degraded.

Claim 13

Dependent Claim 129 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a plurality of spaced-apart annular inner segments of biologically active material penetrated by a rod, said inner segments and said rod being degradable when said bolus is exposed to a liquid environment to release said material, and said casing comprising a plurality of outer segments each having a respective flange extending inwardly to said rod thereby to space apart a respective pair of said inner segments, said outer segments being arranged to be shed from the bolus as said core is progressively degraded.

Claim 14

Dependent Claim 16 words

A release device as set forth in claim 9 wherein said rod is of magnesium alloy.

Claim 15

Dependent Claim 22 words

A release device as set forth in claim 9 wherein the said segments are retained relative to one another by the rod.

Claim 16

Dependent Claim 116 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising first inner segments of a biologically active material, and second inner segments of metal, which may also be biologically active, separating said first inner segments, which first and second inner segments are degradable when the bolus is exposed to a liquid environment, to release said biologically active material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 17

Dependent Claim 116 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising first inner segments of a biologically active material, and second inner segments of metal, which may also be biologically active, separating said first inner segments, which first and second inner segments are degradable when the bolus is exposed to a liquid environment, to release said biologically active material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 18

Dependent Claim 18 words

A release device as set forth in claim 12 wherein said second inner segments are of magnesium alloy.

Claim 19

Dependent Claim 30 words

A release device as set forth in claim 12 wherein said biologically active material is selected from the group consisting of therapeutic agents, anti-coccidials, growth promotants, anthelmintics, insecticides and parasiticides.

Claim 20

Dependent Claim 106 words

A release device in the form of a bolus of generally elongate configuration having two ends said bolus comprising a liquid impermeable casing, a core surrounded by said casing and exposed at least at one of said two ends of the bolus, and means adapted to inhibit regurgitation by an animal dosed with the device, said core comprising a biologically active material and being degradable when the bolus is exposed to the rumen juices of a dosed animal to release said biologically active material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 21

Dependent Claim 106 words

A release device in the form of a bolus of generally elongate configuration having two ends said bolus comprising a liquid impermeable casing, a core surrounded by said casing and exposed at least at one of said two ends of the bolus, and means adapted to inhibit regurgitation by an animal dosed with the device, said core comprising a biologically active material and being degradable when the bolus is exposed to the rumen juices of a dosed animal to release said biologically active material, and said casing comprising a plurality of outer segments which are successively shed from the bolus as said core is progressively degraded.

Claim 22

Dependent Claim 41 words

A release device as set forth in claim 15 wherein said means adapted to inhibit regurgitation comprises weighting means effective to retain the bolus in the rumen of the dosed animal until the biologically active material of the core is spent.

Claim 23

Dependent Claim 84 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments disposed in abutting liquid-tight sealing engagement with each other.

Claim 24

Dependent Claim 84 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments disposed in abutting liquid-tight sealing engagement with each other.

Claim 25

Dependent Claim 87 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments provided with abutting flanges disposed in liquid-tight sealing engagement with each other.

Claim 26

Dependent Claim 87 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments provided with abutting flanges disposed in liquid-tight sealing engagement with each other.

Claim 27

Dependent Claim 87 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments provided with interengageable edges disposed in sealing liquid-tight engagement with each other.

Claim 28

Dependent Claim 87 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite unattached segments provided with interengageable edges disposed in sealing liquid-tight engagement with each other.

Claim 29

Dependent Claim 86 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite segments disposed end-to-end with sealing washers positioned therebetween in sealing liquid-tight engagement therewith.

Claim 30

Dependent Claim 86 words

A release device in the form of a bolus of generally elongate configuration having two ends, said bolus comprising a liquid-impermeable casing and a core surrounded by said casing and exposed at least at one of said two ends of the bolus, said core comprising a biologically-active material and being degradable when the bolus is exposed to a liquid environment to release said material and said casing comprising a plurality of outer finite segments disposed end-to-end with sealing washers positioned therebetween in sealing liquid-tight engagement therewith.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1990-02-09	1990-08-11	1991-02-10	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1994-02-09	1994-08-11	1995-02-10	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1998-02-09	1998-08-11	1999-02-10	$7700.00	Window Closed / Lapsed

Release device

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