US3760805A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Osmotic dispenser with collapsible supply container
Assignee: Alza Corp
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Filing: 1971-01-13
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Granted: 1973-09-25
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Expires: 1991-01-13
Abstract
Abstract An osmotic dispenser is comprised of (1) a water porous housing member confining (2) a first flexible bag of relatively impervious material containing an active agent and provided with active agent dispensing head, and (3) a second bag of controlled permeability to moisture containing a solution which exhibits an osmotic pressure gradient against water. The first and second bags are disposed within the housing member such that water permeates from the external environment through the housing and migrates by osmosis into the solution contained in the second bag which increases in volume thereby generating mechanical force on the first bag, which mechanical force in turn ejects the active agent out of the apparatus.
Inventors
- 👤 T Higuchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:06
CPC Classifications
A; A01; A01G; A01G7/00; A01G7/06; A61; A61D; A61D7/00; A61K; A61K9/00; A61K9/0002; A61K9/0004; B; B01; B01J; B01J4/00; B01J4/04; B65; B65D; B65D1/00; B65D1/02; B65D1/04
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
25 words
The osmotic dispnser as defined by claim 1, wherein the active agent is selected from the group consisting of a drug and a bio-affecting composition.
Claim 2
Dependent Claim
22 words
The osmotic dispenser as defined by claim 1, wherein the active agent contained therein is in the form of a semisolid formulation.
Claim 3
Dependent Claim
24 words
The osmotic dispenser as defined by claim 1, wherein the solution exhibiting an osmotic pressure gradient against water is a saturated aqueous salt solution.
Claim 4
Dependent Claim
19 words
The osmotic dispenser as defined by claim 4, wherein the saturated salt solution contains excess solute in solid form.
Claim 5
Dependent Claim
41 words
The osmotic dispenser as defined by claim 1, wherein the first flexible bag (2) is comprised of a member selected from the group consisting of polyethylene, polyethylene terephthalate, polyvinyl chloride, metal-foil polyethylene laminate, neoprene rubber, natural gum rubber and rubber hydrochloride.
Claim 6
Dependent Claim
36 words
The osmotic dispenser as defined by claim 1, wherein the second bag (3) is comprised of a member selected from the group consisting of cellulose acetate, silicone rubber, polxurethane, natural rubber and hydrolyzed ethylene/vinyl acetate copolymer.
Claim 7
Dependent Claim
58 words
The osmotic dispenser as defined by claim 1, wherein the housing member (1) is comprised of a member selected from the group consisting of perforated polystyrene, perforated polyethylene, perforated polypropylene, perforated polymethylmethacrylate, perforated polyvinyl chloride, perforated reinforced epoxy resin, perforated sheet metal, metallic screen, perforated galvanized pipe, porous sintered brass tubing, porous styrene/acrylonitrile copolymer, and porous sintered polyethylene.
Claim 8
Dependent Claim
29 words
The osmotic dispenser of claim 2 wherein the said housing member (1) is in the configuration of an intravaginal device, ring-shaped, and adapted to be placed around the cervix.
Claim 9
Dependent Claim
20 words
The osmotic dispenser of claim 2 wherein the said housing member (1) is in the configuration of a veterinary bolus.
Claim 10
Dependent Claim
21 words
The osmotic dispenser as defined by claim 1, wherein the bags (2) and (3) are disposed in an essentially parallel configuration.
Claim 11
Dependent Claim
21 words
The osmotic dispenser as defined by claim 1, wherein the bags (2) and (3) are disposed in an essentially concentric configuration.
Claim 12
Dependent Claim
56 words
The osmotic dispenser as defined by claim 1, wherein the osmotically effective solute is selected from the group consisting of magnesium chloride, magnesium sulphate, sodium chloride, potassium sulphate, sodium carbonate, sodium sulphite, sodium sulphate, sodium bicarbonate, potassium acid phthalate, calcium bicarbonate, potassium acid phosphate, raffinose, tartaric acid, succinic acid, calcium succinate, calcium lactate and magnesium succinate.
Claim 13
Dependent Claim
20 words
The osmotic dispenser as defined by Claim 1, further comprising ballast means to adjust the specific gravity of the device.
Claim 14
Dependent Claim
16 words
The osmotic dispenser as defined by claim 14 having a specific gravity of greater than 1.5.
Claim 15
Dependent Claim
25 words
The osmotic dispenser as defined by claim 1, further comprising separator means disposed between the said housing member (1) and the said second bag (3).
Claim 16
Dependent Claim
24 words
The osmotic dispenser as defined by claim 9, further comprising a plurality of duct-like fine tubule connections through the said housing member (1) thereof.
Claim 17
Dependent Claim
128 words
An osmotic active agent dispenser comprising a shape retaining injector divided into two compartments by a flexible diaphragm, one of said compartments having an outer wall of relatively impervious material containing an active agent and provided with means for releasing the active agent to the exterior of the dispenser, and the other compartment having an outer wall of membrane material having controlled permeability to water, being at least in part non-planar in configuration, and containing an osmotically effective solute which, in solution, exhibits an osmotic pressure gradient against water whereby as water flows into the solute compartment in a tendency towards osmotic equilibrium with its environment, said diaphragm expands to continuously squeeze active agent from the dispenser at an osmotically controlled rate over a prolonged period of time.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-09-24 | 1977-03-26 | 1977-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-09-24 | 1981-03-26 | 1981-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-09-24 | 1985-03-26 | 1985-09-25 | $7700.00 | Window Closed / Lapsed |