US4228149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release compositions
Assignee: Pfizer Inc
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Filing: 1978-05-30
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Granted: 1980-10-14
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Expires: 1998-05-30
Abstract
Abstract Sustained release composition comprising a water soluble veterinary medicament dispersed in a sheet of water insoluble polymer, which sheet is of a size and composition such that it is capable of being constrained in a position which allows oral administration and is, in the rumen, capable of moving relative to this position to retain the composition therein.
Inventors
- 👤 Malcolm D. Brewer
- 👤 Gerald J. L. Griffin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0068; A61D; A61D7/00; A61P; A61P43/00
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
98 words
A device adapted for administration to ruminants comprising a water soluble veterinary medicament dispersed in a resilient sheet of water insoluble ethylene-vinyl acetate copolymer, said medicament being present in an amount corresponding to 30 to 75% by weight of said sheet, said copolymer sheet being of a size and composition such that it is capable of being constrained by constraining means in a rolled-up configuration which permits oral administration, said constraining means being operable to release said constrained sheet in the rumen environment, said sheet when unconstrained thereby assuming an unrolled configuration favoring retention thereof in the rumen.
Claim 2
Independent Claim
98 words
A device adapted for administration to ruminants comprising a water soluble veterinary medicament dispersed in a resilient sheet of water insoluble ethylene-vinyl acetate copolymer, said medicament being present in an amount corresponding to 30 to 75% by weight of said sheet, said copolymer sheet being of a size and composition such that it is capable of being constrained by constraining means in a rolled-up configuration which permits oral administration, said constraining means being operable to release said constrained sheet in the rumen environment, said sheet when unconstrained thereby assuming an unrolled configuration favoring retention thereof in the rumen.
Claim 3
Dependent Claim
14 words
A device according to claim 1 wherein the polymer contains 10 to 60% acetate.
Claim 4
Dependent Claim
12 words
A device according to claim 1 wherein the medicant is an anthelmintic.
Claim 5
Dependent Claim
27 words
A device according to claim 3 wherein the anthelmintic is morantel, pyrantel, tetramisole, levamisole, butamisole, nitramisole or diethyl cabamazine, a salt thereof, or a salt of nitroxynil.
Claim 6
Dependent Claim
16 words
A device according to claim 4 wherein the anthelmintic is morantel, levamisole, or a salt thereof.
Claim 7
Dependent Claim
26 words
A device according to claim 1 wherein the medicament is an insecticide, a methane inhibitor, a coccidiostat, a vitamin, a mineral supplement or a growth promotor.
Claim 8
Dependent Claim
18 words
A device according to claim 1 wherein the medicament represents 40 to 65% by weight of the sheet.
Claim 9
Dependent Claim
19 words
A device according to claim 1 comprising a water soluble anthelmintic dispersed in a sheet of ethylene-vinyl acetate copolymer.
Claim 10
Dependent Claim
16 words
A device according to claim 8 wherein the medicament is morentel, levamisole or a salt thereof.
Claim 11
Dependent Claim
18 words
A device according to claim 1 wherein said sheet is coated by a film comprising a water-insoluble polymer.
Claim 12
Dependent Claim
15 words
A device according to claim 10 wherein the polymer contains 10 to 60% vinyl acetate.
Claim 13
Dependent Claim
17 words
A device according to claim 11 wherein the sheet polymer contains from 18 to 21% vinyl acetate.
Claim 14
Dependent Claim
15 words
A device according to claim 17 wherein the film polymer contains about 41.7% vinyl acetate.
Claim 15
Dependent Claim
14 words
A device according to claim 10 wherein the film contains a water degradable filler.
Claim 16
Dependent Claim
16 words
A device according to claim 14 wherein the filler represents 20 to 60% of the film.
Claim 17
Dependent Claim
13 words
A device according to claim 15 wherein the filler is starch or lactose.
Claim 18
Dependent Claim
15 words
A device according to claim 10 wherein the film covers both surfaces of the sheet.
Claim 19
Dependent Claim
12 words
A device according to claim 10 wherein the medicament is an anthelmintic.
Claim 20
Dependent Claim
27 words
A device according to claim 18 wherein the anthelmintic is morantel, pyrantel, tetramisole, levamisole, butamisole, nitramisole or diethyl cabamizine, a salt thereof, or a salt of nitroxynil.
Claim 21
Dependent Claim
18 words
A device according to claim 18 wherein the anthelmintic represents 40 to 65% by weight of the sheet.
Claim 22
Dependent Claim
15 words
A device according to claim 20 wherein the anthelmintic is morantel or a salt thereof.
Claim 23
Dependent Claim
15 words
A device according to claim 20 wherein the anthelmintic is levamisole, or a salt thereof.
Claim 24
Dependent Claim
64 words
A device according to claim 10 wherein the sheet is an ethylene-vinyl acetate copolymer with a vinyl acetate content of 18 to 21% containing 60% morantel citrate and of thickness 1.0 to 1.5 mm, the film coats both surfaces of the sheet, and said film comprises ethylene-vinyl acetate copolymer and 35 to 40% starch and has a thickness of from 0.2 to 0.4 mm.
Claim 25
Dependent Claim
25 words
A method of treatment of disorders in ruminant animals, which method comprises the oral administration to the animal of a device according to claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-14 | 1984-04-14 | 1984-10-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-14 | 1988-04-14 | 1988-10-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-14 | 1992-04-14 | 1992-10-14 | $7700.00 | Window Closed / Lapsed |