US4883699A — Polymeric article having high tensile energy to b…

Claim 1

Independent Claim 151 words

An article, suitable for use as a body implant, having been formed from a multiple phase polymeric composition comprising: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polymeric component capable of absorbing water in an amount of no more than about 30% by weight based on the weight of the non-hydrophilic polymer; and (b) a second phase which comprises a hydrophilic polymeric component capable of absorbing at least about 50% water, by weight based on the weight of the hydrophilic polymer; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 2

Dependent Claim 151 words

An article, suitable for use as a body implant, having been formed from a multiple phase polymeric composition comprising: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polymeric component capable of absorbing water in an amount of no more than about 30% by weight based on the weight of the non-hydrophilic polymer; and (b) a second phase which comprises a hydrophilic polymeric component capable of absorbing at least about 50% water, by weight based on the weight of the hydrophilic polymer; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 3

Dependent Claim 18 words

An article in accordance with claim 1, wherein said second phase is dispersed in said continuous first phase.

Claim 4

Dependent Claim 31 words

An article in accordance with claim 1, wherein said non-hydrophilic polymer component comprises a polyurethane an ethylene-vinyl acetate copolymer, an ethylene-ethyl acrylate copolymer, a low crystalline polyamide or an aliphatic polyester.

Claim 5

Dependent Claim 15 words

An article in accordance with claim 3, wherein the non-hydrophilic polymer component comprises a polyurethane.

Claim 6

Dependent Claim 34 words

An article in accordance with claim 1, wherein the hydrophilic polymeric component comprises polyvinyl alcohol, poly(ethylene oxide), polypropylene oxide, poly(ethylene glycol), polypropylene glycol, polytetramethylene oxide polyvinyl propylidene, polyacrylamide, poly(hydroxy ethyl acrylate) or poly(hydroxyethyl methacrylate).

Claim 7

Dependent Claim 15 words

An article in accordance with claim 5, wherein the hydrophilic polymeric component comprises poly(ethylene oxide).

Claim 8

Dependent Claim 20 words

An article in accordance with claim 1, wherein said multiple phase composition comprises a physical mixture of said polymeric components.

Claim 9

Dependent Claim 13 words

An article in accordance with claim 1, wherein said composition position is crosslinked.

Claim 10

Dependent Claim 20 words

An article in accordance with claim 1, wherein the composition position has a softening ratio of at least about 6:1.

Claim 11

Dependent Claim 20 words

An article in accordance with claim 1, wherein the composition position has a softening ratio of at least about 10:1.

Claim 12

Dependent Claim 19 words

An article in accordance with claim 1, wherein the composition has a swelling ratio of at least about 1.7:1.

Claim 13

Dependent Claim 19 words

An article in accordance with claim 1, wherein the composition has a swelling ratio of at least about 2.0:1.

Claim 14

Dependent Claim 23 words

An article in accordance with claim 1, wherein the composition has a energy to break of at least about 1400 N-cm/cm 3 .

Claim 15

Dependent Claim 25 words

An article in accordance with claim 1, wherein the composition has a 2.5% Secant modulus when hydrated of less than about 4,000 N/cm 2 .

Claim 16

Dependent Claim 21 words

An article in accordance with claim 1, which is a tubular article, the walls of which are made of said composition.

Claim 17

Dependent Claim 13 words

An article in accordance with claim 15, which is a catheter or cannula.

Claim 18

Dependent Claim 158 words

An tubular article suitable for use as a catheter or cannula the walls of which have been formed from a multiple phase polymeric composition comprising a physical mixture of: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polymeric component capable of absorbing water in an amount of no more than about 30% by weight based on the weight of the non-hydrophilic polymer; and (b) a second phase which comprises a hydrophilic polymeric component capable of absorbing at least about 50% water, by weight based on the weight of the hydrophilic polymer; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 19

Dependent Claim 158 words

An tubular article suitable for use as a catheter or cannula the walls of which have been formed from a multiple phase polymeric composition comprising a physical mixture of: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polymeric component capable of absorbing water in an amount of no more than about 30% by weight based on the weight of the non-hydrophilic polymer; and (b) a second phase which comprises a hydrophilic polymeric component capable of absorbing at least about 50% water, by weight based on the weight of the hydrophilic polymer; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 20

Dependent Claim 16 words

A tubular article in accordance with claim 17, wherein said non-hydrophilic polymeric component comprises a polyurethane.

Claim 21

Dependent Claim 15 words

A tubular article in accordance with claim 17, wherein said hydrophilic component comprises polyethylene oxide.

Claim 22

Dependent Claim 109 words

An article suitable for use as a body implant, having been formed from a multiple phase polymeric composition comprising: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polyurethane; and (b) a second phase which comprises a hydrophilic polyethylene oxide; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 23

Dependent Claim 109 words

An article suitable for use as a body implant, having been formed from a multiple phase polymeric composition comprising: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polyurethane; and (b) a second phase which comprises a hydrophilic polyethylene oxide; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 N-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 24

Dependent Claim 18 words

An article in accordance with claim 20, wherein said second phase is dispersed in said continuous first phase.

Claim 25

Dependent Claim 20 words

An article in accordance with claim 21, wherein said multiple phase composition comprises a physical mixture of said polymeric components.

Claim 26

Dependent Claim 12 words

An article in accordance with claim 22, wherein said composition is crosslinked.

Claim 27

Dependent Claim 19 words

An article in accordance with claim 20, wherein the composition has a softening ratio of at least about 6:1.

Claim 28

Dependent Claim 19 words

An article in accordance with claim 20, wherein the composition has a softening ratio of at least about 10:1.

Claim 29

Dependent Claim 19 words

An article in accordance with claim 20, wherein the composition has a swelling ratio of at least about 1.7:1.

Claim 30

Dependent Claim 19 words

An article in accordance with claim 20, wherein the composition has a swelling ratio of at least about 2.0:1.

Claim 31

Dependent Claim 23 words

An article in accordance with claim 20, wherein the composition has a energy to break of at least about 1400 N-cm/cm 3 .

Claim 32

Dependent Claim 25 words

An article in accordance with claim 20, wherein the composition has a 2.5% Secant modulus when hydrated of less than about 4,000 N/cm 2 .

Claim 33

Dependent Claim 119 words

A tubular article suitable for use as a catheter or cannular the walls of which have been formed from a multiple phase polymeric composition comprising a physical mixture of: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polyurethane; and (b) a second phase which comprises a hydrophilic polyethylene oxide; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 n-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Claim 34

Dependent Claim 119 words

A tubular article suitable for use as a catheter or cannular the walls of which have been formed from a multiple phase polymeric composition comprising a physical mixture of: (a) a first phase which is continuous and comprises a substantially non-hydrophilic polyurethane; and (b) a second phase which comprises a hydrophilic polyethylene oxide; wherein said article (i) is capable of absorbing water to an extent that it softens with a softening ratio of at least about 2:1 or swells with a swelling ratio of at least about 1.3:1; and (ii) has an energy to break of at least about 700 n-cm/cm 3 and a 2.5% Secant modulus of less than about 7,000 N/cm 2 , when substantially completely hydrated.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1992-11-27	1993-05-29	1993-11-28	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1996-11-27	1997-05-29	1997-11-28	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2000-11-27	2001-05-29	2001-11-28	$7700.00	Window Closed / Lapsed

Polymeric article having high tensile energy to break when hydrated

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