US3832458A
Expired / Lapsed
US
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Hydrophilic silicone composition and method
Assignee: RIVER C FOUNDATION
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Filing: 1971-12-06
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Granted: 1974-08-27
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Expires: 1991-12-06
Abstract
Abstract A water permeable composition comprising a copolymer of a polysiloxane and N-vinyl pyrrolidone wherein the N-vinyl pyrrolidone is distributed through the thickness of the composition. The composition is useful for forming capsules containing a water soluble drug which can be implanted in an animal to distribute the drug thereto.
Inventors
- 👤 E Merrill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 20:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4816
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
35 words
An implantate for releasing a drug in the tissue of a living organism comprising a drug enclosed in a sealed seamless container in accordance with claim 1 which is in the form of a capsule.
Claim 2
Dependent Claim
13 words
The drug carrier of claim 1 wherein the copolymer contains a reinforcing filler.
Claim 3
Dependent Claim
12 words
The drug carrier of claim 3 wherein the filler is fume silica.
Claim 4
Dependent Claim
12 words
The implantate of claim 2 wherein the copolymer contains a reinforcing filler.
Claim 5
Dependent Claim
17 words
The drug carrier of claim 1 having a hydrophilic polymer grafted to at least one surface thereof.
Claim 6
Dependent Claim
17 words
The drug carrier of claim 2 having a hydrophilic polymer grafted to at least one surface thereof.
Claim 7
Dependent Claim
17 words
The drug carrier of claim 3 having a hydrophilic polymer grafted to, at least, one surface thereof.
Claim 8
Dependent Claim
17 words
The drug carrier of claim 4 having a hydrophilic polymer grafted to at least one surface thereof.
Claim 9
Dependent Claim
17 words
The drug carrier of claim 5 having a hydrophilic polymer grafted to at least one surface thereof.
Claim 10
Dependent Claim
19 words
The drug carrier of claim 1 wherein the N-vinyl pyrrolidone is homogeneously distributed throughout the thickness of the composition.
Claim 11
Dependent Claim
11 words
The drug carrier of claim 1 wherein the drug is water-soluble.
Claim 12
Dependent Claim
10 words
The implantate of claim 2 wherein the drug is water-soluble.
Claim 13
Dependent Claim
12 words
The drug carrier of claim 4 wherein the drug is water soluble.
Claim 14
Dependent Claim
11 words
The implantate of claim 5 wherein the drug is water soluble.
Claim 15
Dependent Claim
12 words
The drug carrier of claim 6 wherein the drug is water soluble.
Claim 16
Dependent Claim
12 words
The drug carrier of claim 7 wherein the drug is water soluble.
Claim 17
Dependent Claim
12 words
The drug carrier of claim 8 wherein the drug is water soluble.
Claim 18
Dependent Claim
12 words
The drug carrier of claim 9 wherein the drug is water soluble.
Claim 19
Dependent Claim
12 words
The drug carrier of claim 10 wherein the drug is water soluble.
Claim 20
Dependent Claim
11 words
The drug carrier of claim 1 wherein the drug is ACTH.
Claim 21
Dependent Claim
27 words
A method for delivering a drug into an animal body which comprises implanting within the lining tissue of the body a drug carrier according to claim 1.
Claim 22
Dependent Claim
19 words
The method of claim 22 wherein at least one surface of said wall has a hydrophilic polymer grafted thereto.
Claim 23
Dependent Claim
12 words
The method of claim 23 wherein said grafted polymer is poly(N-vinyl pyrrolidone).
Claim 24
Dependent Claim
10 words
The method of claim 22 wherein the drug is water-soluble.
Claim 25
Dependent Claim
18 words
The method of claim 22 wherein N-vinyl pyrrolidone is homogeneously distributed throughout the thickness of the drug carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-08-26 | 1978-02-25 | 1978-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-08-26 | 1982-02-25 | 1982-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-08-26 | 1986-02-25 | 1986-08-27 | $7700.00 | Window Closed / Lapsed |