Patent DE2827488C3 successfully refreshed from Google Patents.
Patent US2354241A successfully refreshed from Google Patents.
US4055682A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Catheter and the method of making
Assignee: Sanwa Business Credit Corp
•
Filing: 1976-03-25
•
Granted: 1977-10-25
•
Expires: 1996-03-25
Abstract
Abstract A silicone catheter is rendered hydrophilic by contacting it with N-vinyl pyrrolidone (NVP) in bulk or in solution and exposing the catheter and NVP to ionizing radiation at high dose rate. Penetration of the NVP beyond a thin surface layer is prevented by controlling the dose of ionizing radiation and the concentration of NVP.
Inventors
- 👤 Edward Wilson Merrill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:12
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/0009; A61L; A61L29/00; A61L29/04; A61L29/06; A61L29/08; C; C08; C08L; C08L39/00; C08L39/04; C08L39/06; A61M25/0043; A61M25/0045; A61M2025/0046
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
164 words
The process for rendering superficially hydrophilic a catheter formed from a silicone composition by forming on the surface thereof a hydrophilic polymeric layer so thin that the stiffness of the catheter after treatment when dry is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking, which method comprises contacting the surface of the catheter uniformly with a liquid containing free-radical polymerizable precursor to said hydrophilic polymer layer, said precursor comprising N-vinylpyrrolidone (VNP), NVP and water or NVP, a hydroxalkyl acrylate and water, exposing said surface while in contact with said precursor to high rate dosage of high energy ionizing radiation sufficient to form a hydrophilic surface on said catheter, and controlling the intensity and duration of radiation and the concentration of the precursor to prevent excessive migration of precursor into the silicone polymer composition, thereby causing said precursor to graft to said surface and thereby producing a thin smooth hydrophilic layer uniformly over the entire surface.
Claim 2
Dependent Claim
164 words
The process for rendering superficially hydrophilic a catheter formed from a silicone composition by forming on the surface thereof a hydrophilic polymeric layer so thin that the stiffness of the catheter after treatment when dry is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking, which method comprises contacting the surface of the catheter uniformly with a liquid containing free-radical polymerizable precursor to said hydrophilic polymer layer, said precursor comprising N-vinylpyrrolidone (VNP), NVP and water or NVP, a hydroxalkyl acrylate and water, exposing said surface while in contact with said precursor to high rate dosage of high energy ionizing radiation sufficient to form a hydrophilic surface on said catheter, and controlling the intensity and duration of radiation and the concentration of the precursor to prevent excessive migration of precursor into the silicone polymer composition, thereby causing said precursor to graft to said surface and thereby producing a thin smooth hydrophilic layer uniformly over the entire surface.
Claim 3
Dependent Claim
148 words
The process for rendering superficially hydrophilic a catheter formed from a silicone composition by forming on the surface thereof a hydrophilic polymeric layer so thin that the stiffness of the catheter after treatment when dry is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking, which method comprises contacting the surface of the catheter uniformly with an aqueous solution containing N-vinylpyrrolidone in a volumetric concentration of not greater than 50 vol % NVP, exposing said surface while in contact with said solution to high rate dosage of high energy ionizing radiation sufficient to form a hydrophilic surface on said catheter, and controlling the intensity and duration of the radiation to prevent excessive migration of precursor into the silicone polymer composition, thereby causing NVP to graft to said surface and thereby producing a thin smooth hydrophilic layer over the entire surface.
Claim 4
Dependent Claim
148 words
The process for rendering superficially hydrophilic a catheter formed from a silicone composition by forming on the surface thereof a hydrophilic polymeric layer so thin that the stiffness of the catheter after treatment when dry is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking, which method comprises contacting the surface of the catheter uniformly with an aqueous solution containing N-vinylpyrrolidone in a volumetric concentration of not greater than 50 vol % NVP, exposing said surface while in contact with said solution to high rate dosage of high energy ionizing radiation sufficient to form a hydrophilic surface on said catheter, and controlling the intensity and duration of the radiation to prevent excessive migration of precursor into the silicone polymer composition, thereby causing NVP to graft to said surface and thereby producing a thin smooth hydrophilic layer over the entire surface.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-24 | 1981-04-25 | 1981-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-24 | 1985-04-25 | 1985-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-24 | 1989-04-25 | 1989-10-25 | $7700.00 | Window Closed / Lapsed |