US4714607A
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NMR contrast agents
Assignee: GE Healthcare AS
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Filing: 1985-05-30
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Granted: 1987-12-22
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Expires: 2005-05-30
Abstract
Abstract There are provided NMR contrast agents comprising water-soluble paramagnetic metal chelates, preferably of Cr(III), Fe(III) or Gd(III), wherein the chelating entity is an anilide group containing organic moiety, preferably a compound of formula I ##STR1## wherein R 1 to R 5 may represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups. The agents are especially suitable for use in NMR imaging of the hepatobiliary system.
Inventors
- 👤 Jo Klaveness
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:05
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
70 words
An NMR contrast agent comprising at least one water-soluble non-radioactive paramagnetic metal chelate together with at least one physiologically acceptable carrier or excipient, wherein the chelating entity is a chelating agent of formula I ##STR3## wherein R 1 to R 5 , which may be the same or different, each represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups, or a physiologially acceptable salt thereof.
Claim 2
Dependent Claim
70 words
An NMR contrast agent comprising at least one water-soluble non-radioactive paramagnetic metal chelate together with at least one physiologically acceptable carrier or excipient, wherein the chelating entity is a chelating agent of formula I ##STR3## wherein R 1 to R 5 , which may be the same or different, each represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups, or a physiologially acceptable salt thereof.
Claim 3
Dependent Claim
55 words
A water-soluble non-radioactive paramagnetic metal chelate wherein the chelating entity is the residue of a compound of formula I ##STR4## wherein R 1 to R 5 , which may be the same or diffrent, each represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups, or a physiologically acceptable salt thereof.
Claim 4
Dependent Claim
55 words
A water-soluble non-radioactive paramagnetic metal chelate wherein the chelating entity is the residue of a compound of formula I ##STR4## wherein R 1 to R 5 , which may be the same or diffrent, each represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups, or a physiologically acceptable salt thereof.
Claim 5
Dependent Claim
19 words
A contrast agent as claimed in claim 1 wherein said chelate is a chelate of a trivalent metal ion.
Claim 6
Dependent Claim
33 words
A contrast agent as claimed in claim 3 wherein said chelate is a chelate of a metal ion selected from the group consisting of Cr 3+ , Fe 3+ and Gd 3+ .
Claim 7
Dependent Claim
21 words
A contrast agent as claimed in claim 1 comprising from 0.1 to 200 mM of said paramagnetic metal in aqueous solution.
Claim 8
Dependent Claim
64 words
A contrast agent as claimed in claim 1 wherein R 1 to R 5 are fluorine atoms or R 1 , R 3 and R 5 are hydrogen atoms and R 2 and R 4 are trifluoromethyl groups, or R 1 and R 5 are C 1-4 alkyl groups and R 2 to R 4 are hydrogen atoms, or a physiologically acceptable salt thereof.
Claim 9
Dependent Claim
12 words
A chelate as claimed in claim 2 of a trivalent metal ion.
Claim 10
Dependent Claim
27 words
A chelate as claimed in claim 7 wherein said metal ion is selected from the group consisting of Cr 3+ , Fe 3+ and Gd 3+ .
Claim 11
Dependent Claim
64 words
A chelate as claimed in claim 2 wherein in said chelating entity of formula I R 1 to R 5 are fluorine atoms or R 1 , R 3 and R 5 are hydrogen atoms and R 2 and R 4 are trifluoromethyl groups, or R 1 and R 5 are C 1-4 alkyl groups and R 2 to R 4 are hydrogen atoms.
Claim 12
Dependent Claim
18 words
A contrast agent as claimed in claim 4 wherein said chelate is a chelate of Fe 3+ .
Claim 13
Dependent Claim
18 words
A contrast agent as claimed in claim 4 wherein said chelate is a chelate of Gd 3+ .
Claim 14
Dependent Claim
18 words
A contrast agent as claimed in claim 4 wherein said chelate is a chelate of Cr 3+ .
Claim 15
Dependent Claim
21 words
A contrast agent as claimed in claim 12 wherein said chelating entity is n-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid or a physiologically acceptable salt thereof.
Claim 16
Dependent Claim
19 words
A contrast agent as claimed in claim 13 wherein said chelate is the chromium (III) chelate of N-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 17
Dependent Claim
23 words
A contrast agent as claimed in claim 13 wherein said chelate is the chromium (III) chelate of the meglumine salt of N-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 18
Dependent Claim
19 words
A contrast as claimed in claim 12 wherein said chelate is the chromium (III) chelate of N-(2,6-dimethylphenyl-carbamoylmethyl) iminoacetic acid.
Claim 19
Dependent Claim
20 words
A contrast agent as claimed in claim 12 wherein said chelate is the chromium (III) chelate of N-(2,4,6-trimethylphenyl-carbamoylmethyl) iminodiacetic acid.
Claim 20
Dependent Claim
22 words
A contrast agent as claimed in claim 1 wherein said chelating entity is the meglumine salt of chelating agent of formula I.
Claim 21
Dependent Claim
15 words
A chelate as claimed in claim 8 wherein said metal ion is Fe 3+ .
Claim 22
Dependent Claim
15 words
A chelate as claimed in claim 8 wherein said metal ion is Gd 3+ .
Claim 23
Dependent Claim
15 words
a chelate as claimed in claim 8 wherein said metal ion is Cr 3+ .
Claim 24
Dependent Claim
23 words
A chelate as claimed in claim 21 wherein said chelating entity is the residue of N-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid or a physiologically acceptable salt thereof.
Claim 25
Dependent Claim
15 words
A chelate as claimed in claim 2 being the chromium (III) chelate of N-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 26
Dependent Claim
19 words
A chelate as claimed in claim 2 being the chromium (III) chelate of the meglumine salt of N-(2,6-diethylphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 27
Dependent Claim
15 words
A chelate as claimed in claim 2 being the chromium (III) chelate of N-(2,6-dimethlphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 28
Dependent Claim
15 words
A chelate as claimed in claim 2 being the chromium (III) chelate of N-(2,4,6-trimethylphenyl-carbamoylmethyl)iminodiacetic acid.
Claim 29
Dependent Claim
24 words
A chelate as claimed in claim 2 wherein the chelating entity is the residue of the meglumine salt of a compound of formula I.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-21 | 1991-06-22 | 1991-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-21 | 1995-06-22 | 1995-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-21 | 1999-06-22 | 1999-12-22 | $7700.00 | Window Closed / Lapsed |