US4316883A
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Radioactive composition
Assignee: ICN Switzerland AG
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Filing: 1978-02-21
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Granted: 1982-02-23
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Expires: 1998-02-21
Abstract
Abstract A radioactive composition for the scintigraphic imaging of the hepatobiliary system is disclosed, the composition comprising a complex of 99m Tc with a [2,6-di(lower)alkyl or 2,4,6-tri(lower)alkyl-acetanilido]-iminodiacetic acid having a total of at least 3 carbon atoms in the alkyl groups, or a salt thereof, in sterile aqueous solution. In a preferred composition the complex contains in addition a tin salt and is prepared directly prior to use by reacting NaTcO 4 with SnCl 2 and the iminodiacetic acid.
Inventors
- 👤 Marc de Schrijver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:09
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
72 words
A radioactive composition for the scintigraphic imaging of the hepatobiliary system, the composition comprising a complex of 99m Tc with a dicarboxylic acid of the formula: ##STR4## in which R 1 and R 2 are each an ethyl or an isopropyl group, and R 3 is hydrogen, or each of R 1 , R 2 and R 3 are a methyl group, or one of its water-soluble salts, in sterile, aqueous solution.
Claim 2
Dependent Claim
72 words
A radioactive composition for the scintigraphic imaging of the hepatobiliary system, the composition comprising a complex of 99m Tc with a dicarboxylic acid of the formula: ##STR4## in which R 1 and R 2 are each an ethyl or an isopropyl group, and R 3 is hydrogen, or each of R 1 , R 2 and R 3 are a methyl group, or one of its water-soluble salts, in sterile, aqueous solution.
Claim 3
Dependent Claim
19 words
The composition of claim 1 wherein R 1 , R 2 and R 3 are each a methyl group.
Claim 4
Dependent Claim
15 words
The composition of claim 1 further comprising tin chloride as a component of the complex.
Claim 5
Dependent Claim
15 words
The composition of claim 1 wherein the dicarboxylic acid is present as its sodium salt.
Claim 6
Dependent Claim
16 words
The composition of claim 1 further comprising a tin salt as a component of the complex.
Claim 7
Dependent Claim
38 words
A method of preparing the composition of claim 1, the method comprising allowing the dicarboxylic acid defined in claim 1, or a water-soluble salt thereof, to react under sterile conditions with an aqueous solution containing 99m Tc ions.
Claim 8
Dependent Claim
31 words
The method of claim 8 wherein the dicarboxylic acid or the water-soluble salt thereof is allowed to react with an aqueous 99m Tc-pertechnetate solution in the presence of a tin(II) salt.
Claim 9
Dependent Claim
24 words
The method of claim 7 wherein the 99m Tc-pertechnetate solution is a solution of sodium 99m Tc-pertechnetate and the tin(II) salt is tin(II) chloride.
Claim 10
Dependent Claim
21 words
A method for imaging the hepatobiliary system comprising injecting the composition of claim 1 and subsequently scanning the body for radioactivity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-22 | 1985-08-24 | 1986-02-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-22 | 1989-08-24 | 1990-02-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-22 | 1993-08-24 | 1994-02-23 | $7700.00 | Window Closed / Lapsed |