US4017596A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiopharmaceutical chelates and method of external imaging
Assignee: Research Corp
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Filing: 1975-09-02
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Granted: 1977-04-12
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Expires: 1995-09-02
Abstract
Abstract A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid or an 8-hydroxyquinoline useful as a radiopharmaceutical external imaging agent. The invention also includes preparative methods therefor.
Inventors
- 👤 Michael Dewey Loberg
- 👤 Patrick Stephen Callery
- 👤 Malcolm Cooper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:36
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
15 words
A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid.
Claim 2
Dependent Claim
15 words
A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid.
Claim 3
Dependent Claim
13 words
A chelate of technetium-99m cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and an 8-hyroxyquinoline.
Claim 4
Dependent Claim
13 words
A chelate of technetium-99m cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and an 8-hyroxyquinoline.
Claim 5
Dependent Claim
20 words
A composition comprising a mixture of the technetium-99m chelate of claim 1 and the stannous chelate of said chelating agent.
Claim 6
Dependent Claim
23 words
A composition comprising a mixture of the technetium-99m chelate of claim 1, the stannous chelate of said chelating agent and said chelating agent.
Claim 7
Dependent Claim
32 words
The chelate of claim 1 wherein said iminodiacetic acid chelating agent is N-methyliminodiacetic acid, N-[N'-(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid, N-(10-carboxydecyl) iminodiacetic acid, N-(O-bromobenzyl) iminodiacetic acid, N-[3-(1-naphthyloxy)-2-hydroxypropyl] iminodiacetic acid, nitrilo-triacetic acid or 2,6-pyridinedicarboxylic acid.
Claim 8
Dependent Claim
4 words
N-[N'(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid.
Claim 9
Dependent Claim
4 words
N-[N'(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid.
Claim 10
Dependent Claim
23 words
A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 1.
Claim 11
Dependent Claim
23 words
A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 2.
Claim 12
Dependent Claim
17 words
A method of preparing the chelate of claim 1 comprising reacting said radio-isotope with said chelating agent.
Claim 13
Dependent Claim
10 words
The method of claim 9 wherein said radioisotope is technetium-99m.
Claim 14
Dependent Claim
21 words
The method of claim 10 wherein said chelate is prepared by reducing a pertechnetrate in the presence of said chelating agent.
Claim 15
Dependent Claim
17 words
The method of claim 11 wherein said reduction is effected utilizing stannous chloride as a reducing agent.
Claim 16
Dependent Claim
17 words
A method of preparing the chelate of claim 2 comprising reacting said radio-isotope with said chelating agent.
References Cited (Backward Citations)
US3466361A
Cited
US3728351A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |