US4308249A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiopharmaceutical complexes of N-(tri-substituted alkyl)-iminodiacetic acids
Assignee: GD Searle LLC
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Filing: 1979-12-13
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Granted: 1981-12-29
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Expires: 1999-12-13
Abstract
Abstract Complexes of radiolabelled metals with N-(tri-substituted alkyl)-iminodiacetic acids or salts thereof having utility as radiopharmaceutical agents for monitoring the activity of an organ, their preparation and a method employing such complexes for externally monitoring the activity of an organ are disclosed.
Inventors
- 👤 Patricia Frank
- 👤 Stephen Kraychy
- 👤 Ernest F. Le Von
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:43
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
54 words
A chelate of technetium-99 m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113 m and a compound having the formula ##STR4## wherein X and Y can be the same or different and each represents hydrogen or halogen, Z is carbamoyl or cyano, and n is 2, 3 or 4, or a pharmaceutically acceptable metal salt thereof.
Claim 2
Dependent Claim
54 words
A chelate of technetium-99 m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113 m and a compound having the formula ##STR4## wherein X and Y can be the same or different and each represents hydrogen or halogen, Z is carbamoyl or cyano, and n is 2, 3 or 4, or a pharmaceutically acceptable metal salt thereof.
Claim 3
Dependent Claim
8 words
The chelate of claim 1 of technetium-99 m.
Claim 4
Dependent Claim
12 words
The chelate of claim 1 wherein X and Y are each hydrogen.
Claim 5
Dependent Claim
9 words
The chelate of claim 1 wherein Z is cyano.
Claim 6
Dependent Claim
9 words
The chelate of claim 1 wherein n is 2.
Claim 7
Dependent Claim
8 words
The chelate of claim 1 of N-(3-cyano-3,3-diphenylpropyl)-iminodiacetic acid.
Claim 8
Dependent Claim
12 words
The chelate of claim 1 of a sodium salt of said compound.
Claim 9
Dependent Claim
11 words
The chelate of claim 1 comprising technetium-99 m and N-(3-cyano-3,3-diphenylpropyl)-iminodiacetic acid.
Claim 10
Dependent Claim
39 words
A method of externally monitoring a mammalian liver comprising administering intravenously to the mammal a solution of a chelate of claim 1 and measuring radioraphically the distribution of the chelate throughout the body and its clearance through the liver.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-28 | 1985-06-29 | 1985-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-28 | 1989-06-29 | 1989-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-28 | 1993-06-29 | 1993-12-29 | $7700.00 | Window Closed / Lapsed |