US20030158515A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device and method for intra-bronchial provision of a therapeutic agent
Assignee: Gyrus ACMI Inc
•
Filing: 2002-12-11
•
Granted: —
•
Expires: 2022-12-11
Abstract
Abstract The present invention includes an intra-bronchial device, system, and method for providing a therapeutic agent to a patient. A device includes a flow control member for placement in an air passageway communicating with a lung portion, and when deployed in the air passageway inhibits a therapeutic agent distal of the control member from moving proximal of the control member, and includes the therapeutic agent associated with the flow control member. The control member may inhibit movement of the therapeutic agent by limiting airflow, and may include a one-way valve limiting exhalation of air from the lung portion. The control member may include a flexible membrane impervious to air flow, or a separator arranged to inhibit the movement of the therapeutic agent. The control member may include at least one anchor, and the anchor may be releasable from the air passageway for removal of the intra-bronchial device.
Inventors
- 👤 Hugo Gonzalez
- 👤 Steven Springmeyer
- 👤 Richard Shea
- 👤 John Wang
- 👤 Lauri DeVore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:40
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12027; A61B17/12036; A61B17/1204; A61B17/12099; A61B17/12104; A61B17/12131; A61B17/12159; A61B17/12168; A61B17/12172; A61M25/00; A61M25/01; A61M25/02; A61M25/04; A61B2017/1205; A61B17/22; A61B2017/22051; A61B2017/22065; A61B2017/22067; A61B17/24; A61B2017/242; A61B2217/00; A61B2217/002; A61B2217/005; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2002/043; A61M1/00; A61M1/71; A61M1/79; A61M25/0067; A61M25/0074; A61M25/0075; A61M2025/0076; A61M2210/00; A61M2210/10; A61M2210/1025; A61M2210/1035; A61N; A61N5/00; A61N5/10; A61N5/1001; A61N2005/1019; A61N2005/1021; A61N5/1027
Claims Analysis
Total Claims: 59
Claim 1
Independent Claim
30 words
1 . An intra-bronchial device comprising: a member arranged for placement in an air passageway; and a therapeutic agent associated with the member and arranged for provision to a patient.
Claim 2
Dependent Claim
30 words
1 . An intra-bronchial device comprising: a member arranged for placement in an air passageway; and a therapeutic agent associated with the member and arranged for provision to a patient.
Claim 3
Dependent Claim
27 words
2 . The intra-bronchial device of claim 1 , wherein the member is further arranged for inhibiting the therapeutic agent from moving proximal of the control member.
Claim 4
Dependent Claim
29 words
3 . The intra-bronchial device of claim 1 , further including at least one anchor that retains the intra-bronchial device within the air passageway when the anchor is deployed.
Claim 5
Dependent Claim
26 words
4 . The intra-bronchial device of claim 3 , wherein at least one anchor is releasable from the air passageway for removal of the intra-bronchial device.
Claim 6
Dependent Claim
43 words
5 . A assembly comprising: a therapeutic agent arranged for intra-bronchial delivery into an air passageway of a patient; and a flow control member arranged for placement in the air passageway and inhibiting the therapeutic agent from moving proximal of the control member.
Claim 7
Dependent Claim
43 words
5 . A assembly comprising: a therapeutic agent arranged for intra-bronchial delivery into an air passageway of a patient; and a flow control member arranged for placement in the air passageway and inhibiting the therapeutic agent from moving proximal of the control member.
Claim 8
Dependent Claim
39 words
6 . The assembly of claim 5 , wherein the flow control member is arranged to allow the therapeutic agent to be associated with the flow control member after the flow control member is placed in the air passageway.
Claim 9
Dependent Claim
44 words
7 . The assembly of claim 5 , wherein the flow control member is arranged to allow the therapeutic agent to be placed into the air passageway distal of the flow control member after the flow control member is placed in the air passageway.
Claim 10
Dependent Claim
44 words
8 . An intra-bronchial device for maintaining a therapeutic agent within an air passageway, the device comprising: a flow control member arranged for placement in the air passageway and inhibiting the therapeutic agent from moving proximal of the control member; and the therapeutic agent.
Claim 11
Dependent Claim
44 words
8 . An intra-bronchial device for maintaining a therapeutic agent within an air passageway, the device comprising: a flow control member arranged for placement in the air passageway and inhibiting the therapeutic agent from moving proximal of the control member; and the therapeutic agent.
Claim 12
Dependent Claim
26 words
9 . The intra-bronchial device of claim 8 , wherein the control member inhibits movement of the therapeutic agent by limiting flow from the air passageway.
Claim 13
Dependent Claim
26 words
10 . The intra-bronchial device of claim 8 , wherein the control member inhibits movement of the therapeutic agent by limiting flow into the air passageway.
Claim 14
Dependent Claim
28 words
11 . The intra-bronchial device of claim 8 , wherein the control member inhibits the movement of the therapeutic agent by limiting mucociliary transport from the air passageway.
Claim 15
Dependent Claim
17 words
12 . The intra-bronchial device of claim 8 , wherein the control member includes a one-way valve.
Claim 16
Dependent Claim
21 words
13 . The intra-bronchial device of claim 12 , wherein the one-way valve permits inhalation of air into the air passageway.
Claim 17
Dependent Claim
21 words
14 . The intra-bronchial device of claim 12 , wherein the one-way valve permits exhalation of air from the air passageway.
Claim 18
Dependent Claim
21 words
15 . The intra-bronchial device of claim 8 , wherein the control member includes a flexible membrane impervious to air flow.
Claim 19
Dependent Claim
35 words
16 . The intra-bronchial device of claim 15 , wherein the flexible membrane is arranged in cooperation with a wall of the air passageway to form a one-way valve permitting airflow from the air passageway.
Claim 20
Dependent Claim
35 words
17 . The intra-bronchial device of claim 15 , wherein the flexible membrane is arranged in cooperation with a wall of the air passageway to form a one-way valve permitting airflow into the air passageway.
Claim 21
Dependent Claim
30 words
18 . The intra-bronchial device of claim 8 , wherein the control member includes a separator arranged to inhibit the movement of the therapeutic agent while allowing movement of air.
Claim 22
Dependent Claim
41 words
19 . The intra-bronchial device of claim 18 , wherein molecules of the therapeutic agent are associated with molecules larger than air molecules, and the separator is arranged to inhibit movement of the associated molecules while allowing movement of air molecules.
Claim 23
Dependent Claim
37 words
20 . The intra-bronchial device of claim 8 , wherein the control member includes a semi-permeable membrane arranged to retain the therapeutic agent distal of the control member while permitting air and water molecules to be exhaled.
Claim 24
Dependent Claim
32 words
21 . The intra-bronchial device of claim 8 , wherein the control member limits airflow from the air passageway sufficiently to maintain inflation of a lung portion communicating with the air passageway.
Claim 25
Dependent Claim
27 words
22 . The intra-bronchial device of claim 8 , wherein the control member allows airflow from the air passageway sufficiently to prevent over-inflation of the lung portion.
Claim 26
Dependent Claim
33 words
23 . The intra-bronchial device of claim 8 , wherein the control member further includes at least one anchor that retains the intra-bronchial device within the air passageway when the anchor is deployed.
Claim 27
Dependent Claim
26 words
24 . The intra-bronchial device of claim 23 , wherein at least one anchor is releasable from the air passageway for removal of the intra-bronchial device.
Claim 28
Dependent Claim
27 words
25 . The intra-bronchial device of claim 8 , wherein the control member is further arranged to automatically terminate the inhibiting of movement by the therapeutic agent.
Claim 29
Dependent Claim
22 words
26 . The intra-bronchial device of claim 25 , wherein the automatic termination is provided by a deterioration of the control member.
Claim 30
Dependent Claim
22 words
27 . The intra-bronchial device of claim 25 , wherein the automatic termination is provided by a dissolution of the control member.
Claim 31
Dependent Claim
24 words
28 . The intra-bronchial device of claim 8 , wherein the control member is further arranged to permit mucociliary transport from the air passageway.
Claim 32
Dependent Claim
24 words
29 . The intra-bronchial device of claim 8 , wherein the therapeutic agent is associated with at least a portion of the control member.
Claim 33
Dependent Claim
23 words
30 . The intra-bronchial device of claim 29 , wherein the therapeutic agent overlies at least a portion of the airflow control member.
Claim 34
Dependent Claim
24 words
31 . The device of claim 29 , wherein the therapeutic agent is imbedded in at least a portion of the airflow control member.
Claim 35
Dependent Claim
24 words
32 . The device of claim 29 , wherein the therapeutic agent is absorbed in at least a portion of the airflow control member.
Claim 36
Dependent Claim
24 words
33 . The device of claim 29 , wherein the therapeutic agent is co-mixed with at least a portion of the airflow control member.
Claim 37
Dependent Claim
27 words
34 . The device of claim 29 , wherein the control member further includes an absorptive member and the therapeutic agent is absorbed by the absorptive member.
Claim 38
Dependent Claim
23 words
35 . The device of claim 8 , wherein control member includes a cavity, and the therapeutic agent is carried in the cavity.
Claim 39
Dependent Claim
25 words
36 . The device of claim 35 , wherein the cavity includes an absorptive member, and the therapeutic agent is absorbed by the absorptive member.
Claim 40
Dependent Claim
17 words
37 . The device of claim 35 , wherein the cavity includes a cover having an orifice.
Claim 41
Dependent Claim
69 words
38 . The device of claim 8 , wherein the therapeutic agent is one of antimicrobial agents such as adrenergic agents, antibiotic agents or antibacterial agents, antiviral agents, anthelmintic agents, anti-inflammatory agents, antineoplastic agents, antioxidant agents, biological reaction inhibitors, botulinum toxin agents, chemotherapy agents, diagnostic agents, gene therapy agents, hormonal agents, mucolytic agents, radioprotective agents, radioactive agents including brachytherapy materials, tissue growth inhibitors, tissue growth enhancers, and vasoactive agents.
Claim 42
Dependent Claim
72 words
39 . A system for intra-bronchially providing a therapeutic agent to a patient, the system comprising: an intra-bronchial device including a flow control device arranged for placement in an air passageway, and when deployed, limits flow from the air passageway sufficiently to inhibit a therapeutic agent distal of the control member from moving proximal; and an introducer that introduces the therapeutic agent in the lung portion distal of the airflow control member.
Claim 43
Dependent Claim
72 words
39 . A system for intra-bronchially providing a therapeutic agent to a patient, the system comprising: an intra-bronchial device including a flow control device arranged for placement in an air passageway, and when deployed, limits flow from the air passageway sufficiently to inhibit a therapeutic agent distal of the control member from moving proximal; and an introducer that introduces the therapeutic agent in the lung portion distal of the airflow control member.
Claim 44
Dependent Claim
37 words
40 . A method for providing a therapeutic agent to a patient, the method including the steps of: delivering a therapeutic agent to a lung portion; and inhibiting movement of the therapeutic agent from the lung portion.
Claim 45
Dependent Claim
37 words
40 . A method for providing a therapeutic agent to a patient, the method including the steps of: delivering a therapeutic agent to a lung portion; and inhibiting movement of the therapeutic agent from the lung portion.
Claim 46
Dependent Claim
35 words
41 . The method of claim 40 , wherein the inhibiting step includes the further step of limiting airflow from the lung portion to inhibit therapeutic agent distal of the control member from moving proximal.
Claim 47
Dependent Claim
20 words
42 . The method of claim 40 , including the further step of maintaining an inflation of the lung portion.
Claim 48
Dependent Claim
20 words
43 . The method of claim 40 , including the further step of maintaining a collapse of the lung portion.
Claim 49
Dependent Claim
28 words
44 . The method of claim 40 , wherein the delivering step is performed with one intra-bronchial device and the inhibiting step is performed with another intra-bronchial device.
Claim 50
Dependent Claim
18 words
45 . The method of claim 40 , including the further step of performing the delivering step again.
Claim 51
Dependent Claim
31 words
46 . The method of claim 40 , wherein the inhibiting step includes the further step of implanting an intra-bronchial device in an air passageway in communication with the lung portion.
Claim 52
Dependent Claim
21 words
47 . The method of claim 46 , wherein the delivery step includes providing the therapeutic agent to the intra-bronchial device.
Claim 53
Dependent Claim
18 words
48 . The method of claim 40 , including the further step of terminating the inhibition of movement.
Claim 54
Dependent Claim
69 words
49 . The method of claim 40 , wherein the therapeutic agent is one of antimicrobial agents such as adrenergic agents, antibiotic agents or antibacterial agents, antiviral agents, anthelmintic agents, anti-inflammatory agents, antineoplastic agents, antioxidant agents, biological reaction inhibitors, botulinum toxin agents, chemotherapy agents, diagnostic agents, gene therapy agents, hormonal agents, mucolytic agents, radioprotective agents, radioactive agents including brachytherapy materials, tissue growth inhibitors, tissue growth enhancers, and vasoactive agents.
Claim 55
Dependent Claim
43 words
50 . An intra-bronchial device for providing a therapeutic agent to a patient, the device comprising: means for delivering a therapeutic agent into an air passageway of the patient; and means for intra-bronchially inhibiting movement of the therapeutic agent from the air passageway.
Claim 56
Dependent Claim
43 words
50 . An intra-bronchial device for providing a therapeutic agent to a patient, the device comprising: means for delivering a therapeutic agent into an air passageway of the patient; and means for intra-bronchially inhibiting movement of the therapeutic agent from the air passageway.
Claim 57
Dependent Claim
21 words
51 . The intra-bronchial device of claim 50 , wherein the movement is inhibited by limiting exhalation from the air passageway.
Claim 58
Dependent Claim
21 words
52 . The intra-bronchial device of claim 50 , wherein the movement is inhibited by limiting inhalation into the air passageway.
Claim 59
Dependent Claim
23 words
53 . The intra-bronchial device of claim 50 , wherein the movement is inhibited by limiting movement of mucus from the air passageway.
References Cited (Backward Citations)
US2981254A
Cited
US3439233A
Cited
US3540431A
Cited
US3657744A
Cited
US3788327A
Cited
US3874388A
Cited
US4014318A
Cited
US4086665A
Cited
US4250873A
Cited
US4212463A
Cited
US4850999A
Cited
US4808183A
Cited
US4302854A
Cited
US4819664A
Cited
US4732152A
Cited
US4759758A
Cited
US4710192A
Cited
US4832680A
Cited
US4795449A
Cited
US4852568A
Cited
US4934999A
Cited
US4830003A
Cited
US5413599A
Cited
US4846836A
Cited
US4877025A
Cited
US5116564A
Cited
US4968294A
Cited
US5500014A
Cited
US5352240A
Cited
US5314473A
Cited
US6242472B1
Cited
US5562608A
Cited
US5061274A
Cited
US5411552A
Cited
US5116360A
Cited
US5358518A
Cited
US5161524A
Cited
US5151105A
Cited
US5662713A
Cited
US5123919A
Cited
US5445626A
Cited
US5382261A
Cited
US5409019A
Cited
US5411507A
Cited
US5797960A
Cited
US5306234A
Cited
US5486154A
Cited
US5366478A
Cited
US5431774A
Cited
US5549628A
Cited
US5392775A
Cited
US5803078A
Cited
US5499995C1
Cited
US5499995A
Cited
US5683451A
Cited
US5417226A
Cited
US5736002A
Cited
US5549626A
Cited
US5755770A
Cited
US5693089A
Cited
US5645565A
Cited
US5702409A
Cited
US5697968A
Cited
US5660175A
Cited
US5855601A
Cited
US5725519A
Cited
US6287334B1
Cited
US5851232A
Cited
US6488673B1
Cited
US6281589B1
Cited
US5954766A
Cited
US6558429B2
Cited
US6402806B1
Cited
US6174323B1
Cited
US6287290B1
Cited
US20010056274A1
Cited
US20020062120A1
Cited
US6352081B1
Cited
US6629951B2
Cited
US20010051799A1
Cited
US6293951B1
Cited
US6258100B1
Cited
US20020077593A1
Cited
US6398775B1
Cited
US20010037808A1
Cited
US6679264B1
Cited
US6261955B1
Cited
US6368954B1
Cited
US20020147462A1
Cited
US6527761B1
Cited
US6585639B1
Cited
US20020112729A1
Cited
US20030024527A1
Cited
US20030050648A1
Cited
US20030070682A1
Cited
US20030083671A1
Cited
US6592594B2
Cited
US20030154988A1
Cited
US20040039250A1
Cited
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.