US5562608A
Expired / Lapsed
US
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Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
Assignee: Temple University
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Filing: 1995-04-13
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Granted: 1996-10-08
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Expires: 2015-04-13
Abstract
Abstract An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.
Inventors
- 👤 K. Michael Sekins
- 👤 Thomas H. Shaffer
- 👤 Marla R. Wolfson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61F; A61F7/00; A61F7/12; A61F7/123; A61M; A61M16/00; A61M16/04; A61M16/0402; A61M16/0404; A61M16/0434; A61M16/0454; A61M16/0459; A61M16/0463; A61M16/0475; A61M16/0477; A61M16/0479; A61M16/0486; A61N; A61N7/00; A61N7/02; A61N7/022; B; B06; B06B; B06B1/00; B06B1/02; B06B1/06; B06B1/0607; B06B1/0622; B06B1/0633; A61B; A61B17/00; A61B17/22; A61B2017/22051; A61B2017/22054; A61B18/00; A61B2018/00005; A61B2018/00011; A61F2007/0054; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/33; A61M2205/3368; Y; Y10; Y10S; Y10S128/00; Y10S128/913; Y10T; Y10T137/00; Y10T137/8593; Y10T137/87571; Y10T137/87652
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
49 words
A method for pulmonary delivery of a biological agent, comprising the steps of: providing a substantially homoqeneous liquid carrier comprising a fluorocarbon liquid; suspending an immiscible biological agent in said liquid carrier; and delivering said liquid carrier containing said biological agent through a human or animal's pulmonary air passages.
Claim 2
Independent Claim
49 words
A method for pulmonary delivery of a biological agent, comprising the steps of: providing a substantially homoqeneous liquid carrier comprising a fluorocarbon liquid; suspending an immiscible biological agent in said liquid carrier; and delivering said liquid carrier containing said biological agent through a human or animal's pulmonary air passages.
Claim 3
Dependent Claim
23 words
The method of claim 1, wherein said suspending step is accomplished by dispersing said biological agent in droplet form into said liquid carrier.
Claim 4
Dependent Claim
24 words
The method of claim 2, wherein said dispersing accomplished by passing said biological agent through nozzles located within a flow of said liquid carrier.
Claim 5
Independent Claim
219 words
A method for delivering a biological agent into a human or animal's pulmonary system through the human or animal's pulmonary air passages comprising the steps of: a) providing an apparatus for delivery of a biological agent comprising a conduit having a proximal end adapted to receive a liquid carrier flow, at least one lumen defining a liquid carrier flow path within the conduit, a distal delivery end adapted for delivering the liquid carrier flow to a device that provides liquid communication to pulmonary air passages, a mechanical means for dispersing a biological agent in the liquid carrier flow path within the conduit comprising a plurality of nozzles disposed in spaced array within the liquid carrier flow path wherein each nozzle has a proximal end adapted to receive biological agent and a distal end adapted for delivering the biological agent as a dispersion in the liquid carrier flow; b) introducing the apparatus for delivery of a biological agent into the pulmonary air passages of a human or animal; c) establishing a flow of liquid carrier within the liquid carrier flow path; d) establishing a flow of biological agent through the nozzles thereby dispersing the biological agent within the liquid carrier flow; e) delivering the liquid carrier with dispersed biological agent into the pulmonary air passages of the human or animal.
Claim 6
Independent Claim
219 words
A method for delivering a biological agent into a human or animal's pulmonary system through the human or animal's pulmonary air passages comprising the steps of: a) providing an apparatus for delivery of a biological agent comprising a conduit having a proximal end adapted to receive a liquid carrier flow, at least one lumen defining a liquid carrier flow path within the conduit, a distal delivery end adapted for delivering the liquid carrier flow to a device that provides liquid communication to pulmonary air passages, a mechanical means for dispersing a biological agent in the liquid carrier flow path within the conduit comprising a plurality of nozzles disposed in spaced array within the liquid carrier flow path wherein each nozzle has a proximal end adapted to receive biological agent and a distal end adapted for delivering the biological agent as a dispersion in the liquid carrier flow; b) introducing the apparatus for delivery of a biological agent into the pulmonary air passages of a human or animal; c) establishing a flow of liquid carrier within the liquid carrier flow path; d) establishing a flow of biological agent through the nozzles thereby dispersing the biological agent within the liquid carrier flow; e) delivering the liquid carrier with dispersed biological agent into the pulmonary air passages of the human or animal.
Claim 7
Dependent Claim
26 words
The method of claim 4, wherein the liquid carrier comprises one or more of a fluorocarbon, a perfluorochemical, a perfluorocarbon, a breathable liquid, saline and silicon.
Claim 8
Dependent Claim
28 words
The method of claim 4, further comprising the step of providing the liquid carrier in a substantially degassed state as it is delivered into the pulmonary air passages.
Claim 9
Dependent Claim
19 words
The method of claim 4, further comprising a step of removing the liquid carrier from the pulmonary air passages.
Claim 10
Dependent Claim
27 words
The method of claim 4, further comprising a step of heating the pulmonary air passages, and tissues adjacent the pulmonary air passages, with an ultrasound producing device.
Claim 11
Dependent Claim
27 words
The method of claim 4, wherein the apparatus further comprises a temperature sensor and the method includes the step of sensing the temperature of the liquid carrier.
Claim 12
Dependent Claim
27 words
The method of claim 4, wherein the apparatus further comprises a pressure sensor and the method includes the step of sensing the pressure of the liquid carrier.
Claim 13
Dependent Claim
29 words
The method of claim 4, wherein the method further comprises the step of selectively sealing part of the pulmonary air passages from the remainder of the pulmonary air passages.
Claim 14
Dependent Claim
16 words
The method of claim 11, wherein the sealing step comprises inflating one or more inflatable cuffs.
Claim 15
Dependent Claim
29 words
The method of claim 4, wherein the introducing step is partially accomplished by using a fiber-optic system to locate the position of the apparatus within the pulmonary air passages.
Claim 16
Dependent Claim
28 words
The method of claim 8, wherein the heating step further comprises surgically entering the chest cavity to allow placement of the ultrasound producing device within the chest cavity.
Claim 17
Dependent Claim
31 words
The method of claim 4, wherein the biological agent is in a form comprising one or more of a suspension, a dispersion, a liquid, an emulsion, a powder and an encapsulation.
Claim 18
Dependent Claim
10 words
The method of claim 4, further comprising vibrating the nozzles.
Claim 19
Dependent Claim
15 words
The method of claim 4, further comprising providing oscillatory pulses of pressure to the nozzles.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-10-08 | 2000-04-08 | 2000-10-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-10-08 | 2004-04-08 | 2004-10-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-10-08 | 2008-04-08 | 2008-10-08 | $7700.00 | Window Closed / Lapsed |