US20030014126A1
Expired / Lapsed
US
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Graft prosthesis devices containing renal capsule collagen
Assignee: Cook Biotech Inc
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Filing: 2002-06-28
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Granted: —
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Expires: 2022-06-28
Abstract
Abstract The invention provides tissue graft compositions comprising collagen-based extracellular matrices derived from renal capsules of warm-blooded vertebrates. The invention further provides a process of harvesting and purifying a renal capsule to provide an extracellular matrix material having beneficial use as a tissue graft and/or cell growth material.
Inventors
- 👤 Umesh Patel
- 👤 Michael Hiles
- 👤 Jason Hodde
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:23
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3633; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L26/0057; A61L27/14; A61L27/22; A61L27/24
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
10 words
1 . A tissue graft prosthesis comprising renal capsule collagen.
Claim 2
Dependent Claim
10 words
1 . A tissue graft prosthesis comprising renal capsule collagen.
Claim 3
Dependent Claim
20 words
2 . The tissue graft prosthesis of claim 1 wherein said renal capsule collagen is from a warm blooded vertebrate.
Claim 4
Dependent Claim
16 words
3 . The tissue graft prosthesis of claim 2 comprising a sheet of renal capsule collagen.
Claim 5
Dependent Claim
26 words
4 . The tissue graft prosthesis of claim 3 wherein said sheet of renal capsule collagen exhibits a tensile strength of at least about 4 MPa.
Claim 6
Dependent Claim
28 words
5 . The tissue graft prosthesis of claim 3 wherein said sheet of renal capsule collagen has an endotoxin level no greater than 20 endotoxin units per gram.
Claim 7
Dependent Claim
29 words
6 . The tissue graft prosthesis of claim 5 wherein said sheet of renal capsule collagen has a bioburden level of less than 2 colony forming units per gram.
Claim 8
Dependent Claim
16 words
7 . The tissue graft prosthesis of claim 1 wherein said graft prosthesis is a powder.
Claim 9
Dependent Claim
16 words
8 . The tissue graft prosthesis of claim 1 wherein said graft prosthesis is a tube.
Claim 10
Dependent Claim
18 words
9 . The tissue graft prosthesis of claim 1 wherein said graft prosthesis is an essentially planar sheet.
Claim 11
Dependent Claim
18 words
10 . An article of manufacture comprising renal capsule collagen and sterile packaging containing the renal capsule collagen.
Claim 12
Dependent Claim
18 words
10 . An article of manufacture comprising renal capsule collagen and sterile packaging containing the renal capsule collagen.
Claim 13
Dependent Claim
14 words
11 . The article of claim 10 wherein said renal capsule collagen is dried.
Claim 14
Dependent Claim
16 words
12 . The articles of claim 10 wherein said renal capsule collagen is in hydrated form.
Claim 15
Dependent Claim
16 words
13 . The article of claim 10 wherein said renal capsule collagen is in sheet form.
Claim 16
Dependent Claim
16 words
14 . The article of claim 10 wherein said renal capsule collagen is in powder form.
Claim 17
Dependent Claim
16 words
15 . The article of claim 10 wherein said renal capsule collagen is in tubular form.
Claim 18
Dependent Claim
16 words
16 . The article of claim 10 wherein said renal capsule collagen is in fluidized form.
Claim 19
Dependent Claim
21 words
17 . A method for preparing an extracellular matrix composition, comprising: decellularizing renal capsule tissue to form the extracellular matrix composition.
Claim 20
Dependent Claim
21 words
17 . A method for preparing an extracellular matrix composition, comprising: decellularizing renal capsule tissue to form the extracellular matrix composition.
Claim 21
Dependent Claim
17 words
18 . The method of claim 17 wherein said renal capsule tissue is from a warm-blooded vertebrate.
Claim 22
Dependent Claim
22 words
19 . The method of claim 18 wherein said warm-blooded vertebrate is selected from a group consisting of porcine, bovine and ovine.
Claim 23
Dependent Claim
14 words
20 . The method of claim 18 wherein said warm-blooded vertebrate is a pig.
Claim 24
Dependent Claim
20 words
21 . The method of claim 17 wherein said decellularizing comprises exposing said renal capsule tissue to a decellularization agent.
Claim 25
Dependent Claim
14 words
22 . The method of claim 21 wherein said agent is an oxidizing agent.
Claim 26
Dependent Claim
14 words
23 . The method of claim 21 wherein said agent is a peroxy compound.
Claim 27
Dependent Claim
14 words
24 . The method of claim 23 wherein said peroxy compound is peracetic acid.
Claim 28
Dependent Claim
29 words
25 . The method of claim 17 wherein said tissue graft composition comprises a renal capsule extracellular matrix structure having a tensile strength of at least about 4 MPa.
Claim 29
Dependent Claim
17 words
26 . The method of claim 17 further comprising forming said renal capsule tissue into a powder.
Claim 30
Dependent Claim
17 words
27 . The method of claim 17 further comprising fluidizing said renal capsule tissue by enzyme digestion.
Claim 31
Dependent Claim
15 words
28 . The method of claim 21 wherein said agent is a hypertonic salt solution.
Claim 32
Dependent Claim
15 words
29 . A method of tissue grafting, comprising grafting a mammal with renal capsule collagen.
Claim 33
Dependent Claim
15 words
29 . A method of tissue grafting, comprising grafting a mammal with renal capsule collagen.
Claim 34
Dependent Claim
23 words
30 . The method of tissue grafting of claim 29 wherein said renal capsule collagen is from an animal xenogenic to said mammal.
Claim 35
Dependent Claim
18 words
31 . The method of tissue grafting of claim 30 wherein said renal capsule is porcine renal capsule.
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