US5936256A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preparing a biological material for use in ophthalmology
Assignee: STAAR Surgical AG
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Filing: 1998-11-17
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Granted: 1999-08-10
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Expires: 2018-11-17
Abstract
Abstract A collagen containing substrate comprising cattle basal membrane is conditioned by incubating the membranes in a mixture of pepsin, hyaluronidase and acetic acid and separating the collagen from the mixture. The mixture can include pepsin, hyaluronidase and a 0.5 M solution of acetic acid in 1:1:10 proportions. The incubation is conducted for about 10 hours at about 45° C. After incubation, collagen is separated from the mixture by centrifuging at a speed of 5000 to 30000 rpms for about 30 minutes. The collagen is mixed with polymerizable monomer and polymerized to form a gel that can be ground to form an intraocular or contact lens.
Inventors
- 👤 Svyatoslav Nikolayevich Fedorov
- 👤 Sergei Nikolayevich Bagrov
- 👤 Yevgeny Viktorovich Larionov
- 👤 Vladimir Borisovich Malyshev
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:13
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
13 words
A composition, comprising: collagen containing cattle basal membrane, pepsin, hyaluronidase and acetic acid.
Claim 2
Dependent Claim
13 words
A composition, comprising: collagen containing cattle basal membrane, pepsin, hyaluronidase and acetic acid.
Claim 3
Dependent Claim
20 words
The composition of claim 1, wherein said collagen containing cattle basal membrane is cattle connective tissue comprising Type IV collagen.
Claim 4
Dependent Claim
14 words
The composition of claim 1, wherein said collagen is a non-fibrillar, short chain structure.
Claim 5
Dependent Claim
21 words
The composition of claim 1, wherein said collagen containing cattle basal membrane is from a crystalline lens, kidney capsule or placenta.
Claim 6
Dependent Claim
23 words
The composition of claim 1, comprising cattle basal membrane in a mixture of pepsin, hyaluronidase and acetic acid in about a 1:1:10 proportion.
Claim 7
Dependent Claim
15 words
The composition of claim 5, wherein said acetic acid is about a 0.5 M solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-08-09 | 2003-02-08 | 2003-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-08-09 | 2007-02-08 | 2007-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-08-09 | 2011-02-08 | 2011-08-10 | $7700.00 | Window Closed / Lapsed |