US5352463A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
Assignee: Indiana University Health Inc
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Filing: 1992-11-13
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Granted: 1994-10-04
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Expires: 2012-11-13
Abstract
Abstract A fluidized, injectable tissue graft composition is described. The composition comprises comminuted intestinal submucosa or protease-digested intestinal submucosa. Methods for the preparation and use of injectable tissue graft compositions are described. In preferred embodiments the tissue graft material is prepared from the intestinal submucosa comprising the tunica submucosa, the muscularis mucosa and the stratum compactum of a segment of intestinal tissue of a warm-blooded vertebrate. Effective amounts of the fluidized graft compositions can be injected to promote repair tissue defects by inducing formation of endogenous tissues.
Inventors
- 👤 Steven F. Badylak
- 👤 Robert J. Demeter
- 👤 Michael Hiles
- 👤 Sherry Voytik
- 👤 Peter M. Knapp, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:22
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3629; A61F; A61F2/00; A61F2/0004; A61F2/0031; A61F2/0036; A61F2/02; A61F2/28; A61K; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61L27/3641; A61L27/3645; A61L27/3654; A61F2/04; A61F2/06; A61F2/30; A61F2/38; A61F2/3872; A61F2/08; A61F2002/0894; A61F2002/2835; A61F2002/30001; A61F2002/30316; A61F2002/30535; A61F2002/30581
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
97 words
A method for surgical reconstruction of a collagenous meniscus at the interface of articulating bones, said method comprising the step of surgically implanting into said interface a meniscus graft comprising a sheet of a first tissue graft composition comprising the tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate, said sheet being formed into a sealed pouch and filled with a second tissue graft composition comprising comminuted or protease digested tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate.
Claim 2
Independent Claim
97 words
A method for surgical reconstruction of a collagenous meniscus at the interface of articulating bones, said method comprising the step of surgically implanting into said interface a meniscus graft comprising a sheet of a first tissue graft composition comprising the tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate, said sheet being formed into a sealed pouch and filled with a second tissue graft composition comprising comminuted or protease digested tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate.
Claim 3
Dependent Claim
72 words
A tissue graft construct comprising a sheet of a first tissue graft composition comprising the tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate, said sheet being formed into a sealed pouch and filled with a second tissue graft composition comprising comminuted or protease digested tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate.
Claim 4
Dependent Claim
72 words
A tissue graft construct comprising a sheet of a first tissue graft composition comprising the tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate, said sheet being formed into a sealed pouch and filled with a second tissue graft composition comprising comminuted or protease digested tunica submucosa and basalar portions of the tunica mucosa of a segment of intestine of a warm-blooded vertebrate.
References Cited (Backward Citations)
US4902508A
Cited
US4956178A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-03 | 1998-04-04 | 1998-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-03 | 2002-04-04 | 2002-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-03 | 2006-04-04 | 2006-10-04 | $7700.00 | Window Closed / Lapsed |