US20020035401A1
Expired / Lapsed
US
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Osteogenic implants derived from bone
Assignee: Warsaw Orthopedic Inc
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Filing: 2001-10-09
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Granted: —
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Expires: 2021-10-09
Abstract
Abstract An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
Inventors
- 👤 Todd Boyce
- 👤 David Kaes
- 👤 Nelson Scarborough
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61L; A61L27/00; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/3691; A61F2/30; A61F2002/30001; A61F2002/30316; A61F2002/30535; A61F2250/00; A61F2250/0058; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 43
Claim 1
Independent Claim
50 words
1 . An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the coherent mass formed at least in part from elongate bone-derived elements optionally in combination with bone powder, the osteoimplant possessing an average void volume of not greater than about 32%.
Claim 2
Dependent Claim
50 words
1 . An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the coherent mass formed at least in part from elongate bone-derived elements optionally in combination with bone powder, the osteoimplant possessing an average void volume of not greater than about 32%.
Claim 3
Dependent Claim
19 words
2 . The osteoimplant of claim 1 having a thickness of between about 50 microns and about 2000 microns.
Claim 4
Dependent Claim
40 words
3 . The osteoimplant of claim 1 wherein the coherent mass has a bone element content of from about 5 to 100 weight percent based on the weight of the coherent mass calculated prior to compression of the coherent mass.
Claim 5
Dependent Claim
27 words
4 . The osteoimplant of claim 1 wherein the bone-derived particles are selected from the group consisting of nondemineralized bone particles, demineralized bone particles, and mixtures thereof.
Claim 6
Dependent Claim
26 words
5 . The osteoimplant of claim 1 wherein the bone particles are obtained from cortical, cancellous or cortico-cancellous bone of autogenous, allogenic, xenogenic or transgenic origin.
Claim 7
Dependent Claim
22 words
6 . The osteoimplant of claim 1 wherein the bone particles comprise a mixture of nondemineralized bone particles and demineralized bone particles.
Claim 8
Dependent Claim
24 words
7 . The osteoimplant of claim 1 wherein the ratio of elongate bone-derived elements to bone powder to is between about 1:0 to 1:9.
Claim 9
Dependent Claim
19 words
8 . The osteoimplant of claim 1 wherein the coherent mass is mechanically shaped to a specific three-dimensional architecture.
Claim 10
Dependent Claim
14 words
9 . The osteoimplant of claim 1 wherein the bone-derived particles are fully demineralized.
Claim 11
Dependent Claim
14 words
10 . The osteoimplant of claim 4 further comprising at least one bio-compatible component.
Claim 12
Dependent Claim
38 words
11 . The osteoimplant of claim 10 wherein the biocompatible component is selected from the group consisting of biocompatible fluid carrier, biocompatible binder, filler, fiber, mesh, substance providing radiopacity, plasticizer, biostatic/biocidal agent, surface active agent and bioactive substance.
Claim 13
Dependent Claim
27 words
12 . The osteoimplant of claim 1 further comprising at least one zone of impermeability to soft tissue ingrowth wherein said zone is integral with the osteoimplant.
Claim 14
Dependent Claim
23 words
13 . The osteoimplant of claim 1 configured and dimensioned in the shape of a sheet, plate, disk, tunnel, ring, cone, or tube.
Claim 15
Dependent Claim
68 words
14 . A method of forming an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone particles optionally in combination with one or more biocompatible components, the coherent mass formed at least in part from elongate bone-derived elements optionally in combination with bone powder; and, mechanically shaping the coherent mass of bone particles to form the osteogenic osteoimplant.
Claim 16
Dependent Claim
68 words
14 . A method of forming an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone particles optionally in combination with one or more biocompatible components, the coherent mass formed at least in part from elongate bone-derived elements optionally in combination with bone powder; and, mechanically shaping the coherent mass of bone particles to form the osteogenic osteoimplant.
Claim 17
Dependent Claim
26 words
15 . The method of claim 14 wherein the bone particles are obtained from cortical, cancellous and corticocancellous bone of autogenous, allogenic, xenogenic and transgenic origin.
Claim 18
Dependent Claim
38 words
16 . The method of claim 14 wherein the biocompatible component is selected from the group consisting of biocompatible fluid carrier, biocompatible binder, filler, fiber, mesh, substance providing radiopacity, plasticizer, biostatic/biocidal agent, surface active agent, and bioactive substance.
Claim 19
Dependent Claim
24 words
17 . The method of claim 14 which further comprises applying heat to the composition before, during or after mechanically shaping the coherent mass.
Claim 20
Dependent Claim
25 words
18 . The method of claim 14 which further comprises cross-linking bone particles within the composition before, during or after mechanically shaping the coherent mass.
Claim 21
Dependent Claim
22 words
19 . The method of claim 14 which further comprises dehydrating the composition before, during or after mechanically shaping the coherent mass.
Claim 22
Dependent Claim
21 words
20 . The method of claim 17 which further comprises dehydrating the heated, mechanically shaped coherent mass after applying the heat.
Claim 23
Dependent Claim
18 words
21 . The method of claim 14 wherein the step of mechanically shaping comprises pressing, extruding and/or rolling.
Claim 24
Dependent Claim
16 words
22 . The method of claim 21 further comprising means for the application of lateral force.
Claim 25
Dependent Claim
16 words
23 . The method of claim 22 wherein a compressive and lateral force is applied simultaneously.
Claim 26
Dependent Claim
28 words
24 . The method of claim 14 further comprising the step of placing the coherent mass between two flexible stick-resistant surfaces prior to the step of mechanically shaping.
Claim 27
Dependent Claim
34 words
25 . The method of claim 14 further comprising the step of placing the coherent mass of bone-derived particles on an inflexible, impermeable, horizontally planar work surface prior to the step of mechanically shaping.
Claim 28
Dependent Claim
26 words
26 . The method of claim 25 wherein the step of mechanically shaping further comprises contacting the coherent mass with at least one revolving cylindrical roller.
Claim 29
Dependent Claim
32 words
27 . The method of claim 26 wherein at least one of the revolving cylindrical roller is modified to provide for the surface treatment of one or both surfaces of the osteoimplant.
Claim 30
Dependent Claim
42 words
28 . The method of claim 14 further comprising the step of: occluding a portion of the surface area of the osteoimplant to provide at least one zone of impermeability to soft tissue ingrowth wherein said zone is integral with the osteoimplant.
Claim 31
Dependent Claim
22 words
29 . The method of claim 28 wherein the occluding step comprises heating a portion of the surface area at elevated temperature.
Claim 32
Dependent Claim
27 words
30 . The method of claim 28 wherein the occluding step comprises crosslinking bone particles at a portion of the surface area of the mechanically shaped mass.
Claim 33
Dependent Claim
23 words
31 . The method of claim 14 further comprising the step of shaping the osteoimplant to a determined form, configuration and/or three-dimensional architecture.
Claim 34
Dependent Claim
22 words
32 . The method of claim 14 further comprising the step of layering and fastening the osteoimplant to form a laminate material.
Claim 35
Dependent Claim
40 words
33 . An osteoimplant comprising a mechanically shaped composition of elongate bone particles selected from the group consisting of nondemineralized bone particles, demineralized bone particles, and combinations thereof, wherein the osteoimplant possesses a void volume not greater than about 32%.
Claim 36
Dependent Claim
40 words
33 . An osteoimplant comprising a mechanically shaped composition of elongate bone particles selected from the group consisting of nondemineralized bone particles, demineralized bone particles, and combinations thereof, wherein the osteoimplant possesses a void volume not greater than about 32%.
Claim 37
Dependent Claim
14 words
34 . The osteoimplant of claim 33 further comprising at least one biocompatible component.
Claim 38
Dependent Claim
37 words
35 . The osteoimplant of claim 33 wherein the biocompatible component is selected from the group consisting of biocompatible fluid carrier, biocompatible binder, filler, fiber, mesh, substance imparting radiopacity, surface active agent, bioactive substance and biostatic/biocidal agent.
Claim 39
Dependent Claim
12 words
36 . An osteoimplant prepared by the method of claim 14 .
Claim 40
Dependent Claim
12 words
37 . An osteoimplant prepared by the method of claim 17 .
Claim 41
Dependent Claim
12 words
38 . An osteoimplant prepared by the method of claim 26 .
Claim 42
Dependent Claim
12 words
39 . An osteoimplant prepared by the method of claim 28 .
Claim 43
Dependent Claim
12 words
40 . An osteoimplant prepared by the method of claim 31 .
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