US7001551B2
Expired / Lapsed
US
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Method of forming a composite bone material implant
Assignee: Allograft Research Technologies Inc
•
Filing: 2002-04-23
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Granted: 2006-02-21
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Expires: 2022-04-23
Abstract
Abstract A method of forming a bone composite, comprising: providing bone tissue; grinding said bone tissue to form ground tissue; molding the ground bone tissue into a bone composite; applying a binder to the bone composite; applying a vacuum to the mold, and optionally milling or refining the bone composite to the desired shape. Additionally, bone tissue composites made therefrom are included. The composites may be, for example, a bone pin, screw, or prosthesis.
Inventors
- 👤 Thomas L. Meredith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:58
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61B17/866; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/46; A61F2/4644; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61L27/48; A61L31/00; A61L31/005; A61L31/12; A61L31/125; A61L31/129; A61B17/80; A61F2002/2817; A61F2002/30001; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/30225; A61F2002/30235; A61F2002/30667; A61F2002/30677; A61F2/3094; A61F2/30942; A61F2002/30957; A61F2002/4645; A61F2230/00; A61F2230/0063; A61F2230/0069; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S264/00; Y10S264/78
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
111 words
A method of forming a bone composite, comprising: (i) providing bone tissue; (ii) grinding said bone tissue to form ground bone tissue; (iii) transferring said ground bone tissue into a mold and compacting said ground bone tissue while maintaining canals within said around bone tissue to form a bone composite; (iv) applying a binder to the bone tissue to set within said ground bone tissue and to partially fill the canals of said around bone tissue; (v) applying a vacuum to the mold concurrently with step (iv) to substantially evenly disperse the binder throughout said ground bone tissue; and (vi) optionally milling or refining the bone composite to the desired shape.
Claim 2
Independent Claim
111 words
A method of forming a bone composite, comprising: (i) providing bone tissue; (ii) grinding said bone tissue to form ground bone tissue; (iii) transferring said ground bone tissue into a mold and compacting said ground bone tissue while maintaining canals within said around bone tissue to form a bone composite; (iv) applying a binder to the bone tissue to set within said ground bone tissue and to partially fill the canals of said around bone tissue; (v) applying a vacuum to the mold concurrently with step (iv) to substantially evenly disperse the binder throughout said ground bone tissue; and (vi) optionally milling or refining the bone composite to the desired shape.
Claim 3
Dependent Claim
22 words
The method of claim 1 , wherein the binder is present in an amount of from about 5% to about 80% (w/v).
Claim 4
Dependent Claim
22 words
The method of claim 1 , wherein the binder is present in an amount of from about 20% to about 50% (w/v).
Claim 5
Dependent Claim
18 words
The method of claim 1 , wherein the ground bone tissue is greater than 90% cortical bone tissue.
Claim 6
Dependent Claim
18 words
The method of claim 1 , wherein the ground bone tissue is greater than 95% cortical bone tissue.
Claim 7
Dependent Claim
19 words
The method of claim 1 , wherein the ground bone tissue is from 125 to 850 microns in size.
Claim 8
Dependent Claim
19 words
The method of claim 1 , wherein the binder is applied by an injection, spray, bath, soaking or layering.
Claim 9
Dependent Claim
37 words
The method of claim 1 , wherein the binder is a biological adhesive, bioactive glass ceramic, dental resin sealant, glass ionomer cement, gelatin-resorcinol-formaldehyde glue, collagen-based glue, cellulosic, bioabsorbable polymer, nonbioabsorbable polymer, starch ethylenevinyl alcohol, polycyanoacrylate, or polyphosphazene.
Claim 10
Dependent Claim
21 words
The method of claim 1 , wherein the bone composite is a bone pin, screw, sheet, plate, disk, cylinder or prosthesis.
Claim 11
Dependent Claim
26 words
The method of claim 1 , which further comprises applying a filler, fiber, plasticizer, biostatic/biocidal agent, surface active agent, or bioactive agent to the bone tissue.
Claim 12
Dependent Claim
20 words
The method of claim 1 , wherein the vacuum force is about 29.9 inches Hg to about 19.7 inches Hg.
Claim 13
Dependent Claim
20 words
The method of claim 1 , wherein the vacuum force is about 29.5 inches Hg to about 24 inches Hg.
Claim 14
Dependent Claim
25 words
The method of claim 1 , wherein the vacuum is applied to the mold for a period of about 1 second to about 10 minutes.
Claim 15
Dependent Claim
27 words
The method of claim 1 , wherein the vacuum is applied to the mold for a period of about 1 second to less than about 1 minute.
Claim 16
Dependent Claim
22 words
The method of claim 1 , wherein the compressive force is applied for a period of 1 second to about 10 minutes.
Claim 17
Dependent Claim
16 words
The method of claim 1 , wherein the (iv) begins at the same time as (v).
Claim 18
Dependent Claim
13 words
The method of claim 1 , wherein (iv) and (v) overlaps in time.
Claim 19
Dependent Claim
26 words
The method of claim 1 , wherein (v) overlaps in time with the application of a compressive force of less than 1,000 psi to the mold.
Claim 20
Dependent Claim
26 words
The method of claim 1 , further comprising: applying a compressive force of less than 1000 psi to the mold to compact said ground bone tissue.
Claim 21
Dependent Claim
15 words
The method of claim 19 , wherein the compressive force is less than 200 psi.
Claim 22
Dependent Claim
16 words
The method of claim 19 , wherein the compressive force is applied before (v) is complete.
Claim 23
Dependent Claim
15 words
The method of claim 1 , wherein the bone tissue is substantially cortical bone tissue.
Claim 24
Dependent Claim
13 words
The method of claim 22 , wherein the bone tissue is substantially demineralized.
Claim 25
Dependent Claim
17 words
The method of claim 22 , wherein the bone tissue is greater than 70% cortical bone tissue.
Claim 26
Dependent Claim
11 words
The method of claim 1 , wherein the binder comprises cyanoacrylates.
Claim 27
Dependent Claim
16 words
The method of claim 25 , wherein the cyanoacrylates comprise ester chain, N-butyl, or butyl cyanoacrylates.
Claim 28
Dependent Claim
13 words
The method of claim 25 , wherein the cyanoacrylates are long chain cyanoacrylates.
Claim 29
Dependent Claim
17 words
The method of claim 1 , wherein the ground bone tissue is hydrated after the grinding step.
Claim 30
Dependent Claim
22 words
The method of claim 28 , wherein the ground bone tissue is hydrated in an amount of 1 to about 5% (volume).
Claim 31
Dependent Claim
12 words
The method of claim 28 , wherein the hydrate is demineralized water.
Claim 32
Independent Claim
145 words
A method of forming a bone composite, comprising: (i) providing bone tissue; (ii) grinding said bone tissue to form ground bone tissue ranging in size from about 125 microns to about 850 microns;. (iii) hydrating and transferring said ground bone tissue into a mold and compacting said ground bone tissue while maintaining voids within said around bone tissue to form a bone composite; (iv) applying a cyanoacrylate binder to the bone tissue to set within said ground bone tissue and to partially fill the voids of said around bone tissue; (v) applying a vacuum to the mold concurrently with step (iv) to substantially evenly disperse the cyanoacrylate binder throughout said ground bone tissue; (vi) applying a compressive force of less than 1000 psi to the mold to compact said ground bone tissue; and (vii) optionally milling or refining the bone composite to the desired shape.
Claim 33
Independent Claim
145 words
A method of forming a bone composite, comprising: (i) providing bone tissue; (ii) grinding said bone tissue to form ground bone tissue ranging in size from about 125 microns to about 850 microns;. (iii) hydrating and transferring said ground bone tissue into a mold and compacting said ground bone tissue while maintaining voids within said around bone tissue to form a bone composite; (iv) applying a cyanoacrylate binder to the bone tissue to set within said ground bone tissue and to partially fill the voids of said around bone tissue; (v) applying a vacuum to the mold concurrently with step (iv) to substantially evenly disperse the cyanoacrylate binder throughout said ground bone tissue; (vi) applying a compressive force of less than 1000 psi to the mold to compact said ground bone tissue; and (vii) optionally milling or refining the bone composite to the desired shape.
Claim 34
Dependent Claim
15 words
The method of claim 31 , wherein the bone tissue is substantially cortical bone tissue.
Claim 35
Dependent Claim
13 words
The method of claim 31 , wherein the bone tissue is substantially demineralized.
Claim 36
Dependent Claim
18 words
The method of claim 31 , wherein the bone tissue is greater than about 90% cortical bone tissue.
Claim 37
Dependent Claim
20 words
The method of claim 31 , wherein the vacuum force is about 29.5 inches Hg to about 24 inches Hg.
Claim 38
Dependent Claim
18 words
The method of claim 31 , wherein the vacuum time is about 1 second to about 1 minute.
Claim 39
Dependent Claim
22 words
The method of claim 31 , wherein the compressive force occurs for a period of about 1 second to about 10 minutes.
Claim 40
Dependent Claim
13 words
The method of claim 31 , wherein (v) and (vi) overlap in time.
Claim 41
Dependent Claim
13 words
The method of claim 31 , wherein (iv) and (v) overlap in time.
Claim 42
Dependent Claim
15 words
The method of claim 31 , wherein the compressive force is less than 200 psi.
Claim 43
Dependent Claim
14 words
The method of claim 31 , wherein (v) is complete before (vi) is complete.
Claim 44
Dependent Claim
18 words
The method of claim 41 , further comprising a second application of a vacuum after (vi) is complete.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2009-02-20 | 2009-08-22 | 2010-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2013-02-20 | 2013-08-22 | 2014-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2017-02-20 | 2017-08-22 | 2018-02-21 | $7700.00 | Window Closed / Lapsed |