US6699231B1
Expired / Lapsed
US
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Methods and apparatus for perfusion of isolated tissue structure
Assignee: PINPOINT THERAPEUTICS Inc
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Filing: 1998-12-30
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Granted: 2004-03-02
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Expires: 2018-12-30
Abstract
Abstract Organs and other tissue structures are isolated and perfused with a therapeutic agent. Isolation is effected by endovascularly positioning catheters having occlusion balloons within the arteries or other blood vessels which supply blood to the organ. Similarly, blood flow from the organ back to the patient's circulatory system is blocked by endovascularly positioning one or more catheters carrying occlusion members within the veins or other blood vessels leading from the organ. The therapeutic agent may then be perfused through the organ in either an antegrade or retrograde fashion using the endovascularly positioned catheters while maintaining isolation.
Inventors
- 👤 Wesley D. Sterman
- 👤 John H. Stevens
- 👤 Hanson S. Gifford, III
- 👤 Lawrence C. Siegel
- 👤 Joe B. Putnam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:22
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12131; A61B17/12136; A61B17/12027; A61B17/1204; A61B17/12045; A61B17/12099; A61B17/12109; A61M; A61M1/00; A61M1/36; A61M1/3613; A61M25/00; A61M25/10; A61M25/1011; A61B2017/12127; A61M1/3615; A61M2025/1043; A61M2025/1052
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
212 words
A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient's circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising: endovascularly positioning a first catheter in the artery; endovascularly positioning a second catheter in the vein; occluding the artery around the first catheter; occluding the vein around the second catheter; delivering a perfusate comprising a therapeutic agent and an oxygen carrier to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, the tissue structure being an organ selected from the group consisting of the brain, at least one breast, at least one lung, at least one kidney, the liver, the spleen, the stomach, the intestines, the pancreas, the colon, the bladder, the thyroid gland, and the prostate; collecting the perfusate through the other of the at least one of the first and second catheters after the perfusate has perfused at least a portion of the tissue structure; extracorporeally pumping the perfusate back to the at least one of the first and second catheters; and extracorporeally oxygenating the oxygen carrier.
Claim 2
Independent Claim
212 words
A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient's circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising: endovascularly positioning a first catheter in the artery; endovascularly positioning a second catheter in the vein; occluding the artery around the first catheter; occluding the vein around the second catheter; delivering a perfusate comprising a therapeutic agent and an oxygen carrier to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, the tissue structure being an organ selected from the group consisting of the brain, at least one breast, at least one lung, at least one kidney, the liver, the spleen, the stomach, the intestines, the pancreas, the colon, the bladder, the thyroid gland, and the prostate; collecting the perfusate through the other of the at least one of the first and second catheters after the perfusate has perfused at least a portion of the tissue structure; extracorporeally pumping the perfusate back to the at least one of the first and second catheters; and extracorporeally oxygenating the oxygen carrier.
Claim 3
Dependent Claim
32 words
The method as in claim 1 , wherein the perfusate is delivered through the first catheter into the artery and collected from the vein by the second catheter to establish antegrade perfusion.
Claim 4
Dependent Claim
32 words
The method as in claim 1 , wherein the perfusate is delivered through the second catheter into the vein and collected from the artery by the first catheter to establish retrograde perfusion.
Claim 5
Dependent Claim
28 words
A method as in claim 1 , wherein the perfusate comprises an agent selected from the group consisting of a drug, a diagnostic agent, and a biologic material.
Claim 6
Dependent Claim
16 words
The method as in claim 1 , wherein the oxygenated carrier is a synthetic oxygen carrier.
Claim 7
Dependent Claim
14 words
The method as in claim 1 , wherein the oxygenated carrier is oxygenated blood.
Claim 8
Dependent Claim
18 words
The method of claim 1 , comprising the step of heating the tissue structure during the delivering step.
Claim 9
Dependent Claim
23 words
The method of claim 7 , wherein the heating step raises the temperature of the tissue structure to at least about 100° F.
Claim 10
Dependent Claim
23 words
The method of claim 7 , wherein the heating step raises the temperature of the tissue structure to at least about 105° F.
Claim 11
Dependent Claim
28 words
The method of claim 7 , wherein the heating step comprises heating the perfusate before the delivering step, and wherein the perfusate transfers heat to the tissue structure.
Claim 12
Independent Claim
137 words
A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient's circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising: endovascularly positioning a first catheter in the artery; endovascularly positioning a second catheter in the vein; occluding the artery around the first catheter; and occluding the vein around the second catheter; and delivering a perfusate to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, wherein the tissue structure is a liver, the first catheter occludes a hepatic artery, the second catheter occludes a hepatic vein, and a third catheter occludes a portal vein.
Claim 13
Independent Claim
137 words
A method of treatment of a tissue structure in a patient, the tissue structure being coupled to an artery through which blood flows from the patient's circulatory system to the tissue structure and to a vein through which blood flows away from the tissue structure to the circulatory system, the method comprising: endovascularly positioning a first catheter in the artery; endovascularly positioning a second catheter in the vein; occluding the artery around the first catheter; and occluding the vein around the second catheter; and delivering a perfusate to the tissue structure through at least one of the first and second catheters while the artery and vein remain occluded, wherein the tissue structure is a liver, the first catheter occludes a hepatic artery, the second catheter occludes a hepatic vein, and a third catheter occludes a portal vein.
Claim 14
Dependent Claim
15 words
The method as in claim 11 , further comprising adding therapeutic agent to the perfusate.
Claim 15
Dependent Claim
32 words
The method as in claim 11 , wherein the perfusate is delivered through at least one of the first and third catheters and collected in the second catheter to establish antegrade perfusion.
Claim 16
Dependent Claim
32 words
The method as in claim 11 , wherein the perfusate is delivered through the second catheter and collected in at least one of the first and third catheters to establish retrograde perfusion.
Claim 17
Dependent Claim
18 words
The method of claim 11 , comprising the step of heating the tissue structure during the delivering step.
Claim 18
Dependent Claim
23 words
The method of claim 15 , wherein the heating step raises the temperature of the tissue structure to at least about 100° F.
Claim 19
Dependent Claim
23 words
The method of claim 15 , wherein the heating step raises the temperature of the tissue structure to at least about 105° F.
Claim 20
Dependent Claim
28 words
The method of claim 15 , wherein the heating step comprises heating the perfusate before the delivering step, and wherein the perfusate transfers heat to the tissue structure.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2007-03-02 | 2007-09-01 | 2008-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-03-02 | 2011-09-01 | 2012-03-02 | $3760.00 | Window Closed / Lapsed |
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