US6077256A
Expired / Lapsed
US
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Delivery of a composition to the lung
Assignee: Anesiva Inc
•
Filing: 1998-10-06
•
Granted: 2000-06-20
•
Expires: 2018-10-06
Abstract
Abstract In general, the invention features methods for delivering a composition to the lung in a non-surgical, percutaneous approach by utilizing the pulmonary vasculature (i.e., the pulmonary arteries and veins). Also disclosed are methods allowing for the lung-specific delivery of a composition, as well as a catheter that includes a deployable arm.
Inventors
- 👤 Michael J. Mann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:53
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3687; A61M1/3615; A61B; A61B90/00; A61B90/39; A61B2090/3954; A61M25/00; A61M25/0043; A61M2025/0057
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
109 words
A method for delivering a composition to a lung, said method comprising the steps of: (a) inserting a pulmonary artery catheter into a pulmonary artery supplying said lung via a first non-surgical percutaneous route, wherein said pulmonary artery catheter comprises a deployable means for occluding said inserted pulmonary artery; (b) inserting a pulmonary vein catheter into a pulmonary vein draining said lung via a second non-surgical percutaneous route, wherein said pulmonary vein catheter comprises a deployable means for occluding said inserted pulmonary vein; and (c) delivering said composition to said lung via at least one of the group consisting of said pulmonary artery catheter and said pulmonary vein catheter.
Claim 2
Independent Claim
109 words
A method for delivering a composition to a lung, said method comprising the steps of: (a) inserting a pulmonary artery catheter into a pulmonary artery supplying said lung via a first non-surgical percutaneous route, wherein said pulmonary artery catheter comprises a deployable means for occluding said inserted pulmonary artery; (b) inserting a pulmonary vein catheter into a pulmonary vein draining said lung via a second non-surgical percutaneous route, wherein said pulmonary vein catheter comprises a deployable means for occluding said inserted pulmonary vein; and (c) delivering said composition to said lung via at least one of the group consisting of said pulmonary artery catheter and said pulmonary vein catheter.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein said lung comprises two or more pulmonary veins that drain said lung.
Claim 4
Dependent Claim
78 words
The method of claim 2, wherein step (b) further comprises inserting a pulmonary vein catheter into each of said pulmonary veins draining said lung, wherein each of said pulmonary vein catheters comprises a deployable means for occluding the pulmonary vein into which it is inserted, the number of pulmonary vein catheters is equal to the number of pulmonary veins draining said lung, and not more than one of said pulmonary vein catheters is inserted into one pulmonary vein.
Claim 5
Dependent Claim
31 words
The method of claim 2, wherein said pulmonary vein catheter further comprises a number of deployable arms that is equal to the number of pulmonary veins draining said lung minus one.
Claim 6
Dependent Claim
67 words
The method of claim 4, wherein step (b) further comprises inserting said deployable arms of said pulmonary vein catheter into said number of pulmonary veins draining said lung minus one, wherein each of said deployable arms, when deployed, comprises a deployable means for occluding the pulmonary vein into which it is inserted, and not more than one of said deployable arms is inserted into one pulmonary vein.
Claim 7
Dependent Claim
40 words
The method of claim 5, wherein said delivery step is via at least one of the group consisting of said pulmonary artery catheter, said pulmonary vein catheter, and at least one of said deployable arms of said pulmonary vein catheter.
Claim 8
Dependent Claim
54 words
The method of claim 6, wherein said composition delivered to said lung is collected by at least one of the group consisting of said pulmonary artery catheter, said pulmonary vein catheter, and at least one of said deployable arms of said pulmonary vein catheter, wherein said delivering catheter and said collecting catheter are different.
Claim 9
Dependent Claim
32 words
The method of claim 7, wherein said delivery catheter is connected to said collecting catheter, whereby said composition collected by said collecting catheter is returned to said lung by said delivering catheter.
Claim 10
Dependent Claim
32 words
The method of claim 3, wherein said delivering step is via at least one of the group consisting of said pulmonary artery catheter and at least one of said pulmonary vein catheters.
Claim 11
Dependent Claim
46 words
The method of claim 7, wherein said composition delivered to said lung is collected by at least one of the group consisting of said pulmonary artery catheter and at least one of said pulmonary vein catheters, wherein said delivering catheter and said collecting catheter are different.
Claim 12
Dependent Claim
32 words
The method of claim 10, wherein said delivering catheter is connected to said collecting catheter, whereby said composition collected by said collecting catheter is returned to said lung by said delivering catheter.
Claim 13
Dependent Claim
42 words
The method of claim 1, wherein said composition delivered to said lung is collected by at least one of the group consisting of said pulmonary artery catheter and said pulmonary vein catheter, wherein said delivering catheter and said collecting catheter are different.
Claim 14
Dependent Claim
32 words
The method of claim 12, wherein said delivering catheter is connected to said collecting catheter, whereby said composition collected by said collecting catheter is returned to said lung by said delivering catheter.
Claim 15
Dependent Claim
28 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter is adapted for insertion via a conventional introducer sheathe.
Claim 16
Dependent Claim
26 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter is adapted for insertion over a guidewire.
Claim 17
Dependent Claim
27 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter is equipped with a gauge for monitoring pressure.
Claim 18
Dependent Claim
29 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter is equipped with a flow meter for monitoring flow rate.
Claim 19
Dependent Claim
25 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter is at least in part radio-opaque.
Claim 20
Dependent Claim
37 words
The method of claim 1, wherein at least one of said pulmonary artery catheter and said pulmonary vein catheter further comprises a lumen that is in communication with a port located distal to said deployable occluding means.
Claim 21
Dependent Claim
41 words
The method of claim 1, wherein at least one of said first non-surgical percutaneous route and said second non-surgical percutaneous route is visualized by a guidance technique selected from the group consisting of ultrasound guidance, radiographic guidance, and magnetic resonance guidance.
Claim 22
Dependent Claim
15 words
The method of claim 1, wherein said first non-surgical percutaneous route is an intravenous approach.
Claim 23
Dependent Claim
15 words
The method of claim 1, wherein said second non-surgical percutaneous route is an intra-arterial approach.
Claim 24
Dependent Claim
29 words
The method of claim 1, wherein, said composition is delivered to said lung via said pulmonary vein catheter and is collected from said lung via said pulmonary artery catheter.
Claim 25
Independent Claim
131 words
A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of: (a) inserting a pulmonary vein catheter into a pulmonary vein of said lung via a non-surgical percutaneous route, wherein said pulmonary vein catheter comprises (i) a deployable means for occluding the pulmonary vein into which it has been inserted, and (ii) a number of deployable arms that is equal to the number of pulmonary veins of said lung minus one; (b) inserting each of said deployable arms into a different pulmonary vein of said lung, wherein the pulmonary vein into which a deployable arm is inserted does not contain said pulmonary vein catheter; and (b) delivering said drug to said lung via said pulmonary vein catheter and said deployable arms.
Claim 26
Independent Claim
131 words
A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of: (a) inserting a pulmonary vein catheter into a pulmonary vein of said lung via a non-surgical percutaneous route, wherein said pulmonary vein catheter comprises (i) a deployable means for occluding the pulmonary vein into which it has been inserted, and (ii) a number of deployable arms that is equal to the number of pulmonary veins of said lung minus one; (b) inserting each of said deployable arms into a different pulmonary vein of said lung, wherein the pulmonary vein into which a deployable arm is inserted does not contain said pulmonary vein catheter; and (b) delivering said drug to said lung via said pulmonary vein catheter and said deployable arms.
Claim 27
Dependent Claim
30 words
The method of claim 24, wherein said non-surgical percutaneous route is visualized by a guidance technique selected from the group consisting of ultrasound guidance, radiographic guidance, and magnetic resonance guidance.
Claim 28
Dependent Claim
14 words
The method of claim 24, wherein said non-surgical percutaneous route is an intravenous approach.
Claim 29
Dependent Claim
19 words
The method of claim 24, wherein said pulmonary vein catheter is adapted for insertion via a conventional introducer sheathe.
Claim 30
Dependent Claim
17 words
The method of claim 24, wherein said pulmonary vein catheter is adapted for insertion over a guidewire.
Claim 31
Dependent Claim
18 words
The method of claim 24, wherein said pulmonary vein catheter is equipped with a gauge for monitoring pressure.
Claim 32
Dependent Claim
20 words
The method of claim 24, wherein said pulmonary vein catheter is equipped with a flow meter for monitoring flow rate.
Claim 33
Dependent Claim
16 words
The method of claim 24, wherein said pulmonary vein catheter is at least in part radio-opaque.
Claim 34
Dependent Claim
28 words
The method of claim 24, wherein said pulmonary vein catheter further comprises a lumen that is in communication with a port located distal to said deployable occluding means.
Claim 35
Independent Claim
85 words
A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of: (a) inserting a pulmonary vein catheter into each pulmonary vein of said lung via a non-surgical percutaneous route, wherein each pulmonary vein catheter comprises a deployable means for occluding the pulmonary vein into which it has been inserted and not more than one catheter is inserted into a single pulmonary vein; and (b) delivering said drug to said lung via the pulmonary vein catheters.
Claim 36
Independent Claim
85 words
A method for delivering a drug to a lung comprising more than one pulmonary vein, said method comprising the steps of: (a) inserting a pulmonary vein catheter into each pulmonary vein of said lung via a non-surgical percutaneous route, wherein each pulmonary vein catheter comprises a deployable means for occluding the pulmonary vein into which it has been inserted and not more than one catheter is inserted into a single pulmonary vein; and (b) delivering said drug to said lung via the pulmonary vein catheters.
Claim 37
Dependent Claim
30 words
The method of claim 33, wherein said non-surgical percutaneous route is visualized by a guidance technique selected from the group consisting of ultrasound guidance, radiographic guidance, and magnetic resonance guidance.
Claim 38
Dependent Claim
12 words
The method of claim 33, wherein said non-surgical percutaneous route is intravenous.
Claim 39
Dependent Claim
20 words
The method of claim 33, wherein said pulmonary vein catheter is adapted for vein insertion via a conventional introducer sheathe.
Claim 40
Dependent Claim
17 words
The method of claim 33, wherein said pulmonary vein catheter is adapted for insertion over a guidewire.
Claim 41
Dependent Claim
18 words
The method of claim 33, wherein said pulmonary vein catheter is equipped with a gauge for monitoring pressure.
Claim 42
Dependent Claim
20 words
The method of claim 33, wherein said pulmonary vein catheter is equipped with a flow meter for monitoring flow rate.
Claim 43
Dependent Claim
16 words
The method of claim 33, wherein said pulmonary vein catheter is at least in part radio-opaque.
Claim 44
Dependent Claim
28 words
The method of claim 33, wherein said pulmonary vein catheter further comprises a lumen that is in communication with a port located distal to said deployable occluding means.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-06-20 | 2003-12-20 | 2004-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-20 | 2007-12-20 | 2008-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-06-20 | 2011-12-20 | 2012-06-20 | $7700.00 | Window Closed / Lapsed |