US6666886B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue equivalent approach to a tissue-engineered cardiovascular valve
Assignee: University of Minnesota System
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Filing: 2000-02-16
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Granted: 2003-12-23
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Expires: 2020-02-16
Abstract
Abstract The invention provides a molded valve leaflet containing a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment. The invention also provides a valve equivalent containing a plurality of molded valve leaflets that are connected to a base, wherein the molded valve leaflets include a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.
Inventors
- 👤 Robert T. Tranquillo
- 👤 Timothy S. Girton
- 👤 Michael Neidert
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:08
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61F2/2415; A61L27/14; A61L27/22; A61L27/225; A61L27/24; A61L27/3839; A61L27/3843; A61F2/2475
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
26 words
A molded valve leaflet comprising a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.
Claim 2
Dependent Claim
26 words
A molded valve leaflet comprising a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.
Claim 3
Dependent Claim
13 words
The molded valve leaflet of claim 1 , wherein the biopolymer is cross-linked.
Claim 4
Dependent Claim
30 words
The molded valve leaflet of claim 2 , wherein a stress-strain curve obtained using the molded valve leaflet is similar to a stress-strain curve obtained using a native valve leaflet.
Claim 5
Dependent Claim
15 words
The molded valve leaflet of claim 1 , wherein the biopolymer is a fibrillar biopolymer.
Claim 6
Dependent Claim
16 words
The molded valve leaflet of claim 4 , wherein the fibrillar biopolymer is collagen or fibrin.
Claim 7
Dependent Claim
15 words
The molded valve leaflet of claim 1 , wherein the cells are fibroblasts or myofibroblasts.
Claim 8
Dependent Claim
28 words
The molded valve leaflet of claim 1 , wherein the molded valve leaflet is a replacement for a native heart valve leaflet or a native venous valve leaflet.
Claim 9
Dependent Claim
41 words
A valve equivalent comprising a plurality of molded valve leaflets connected to a base, wherein the molded valve leaflets comprise a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.
Claim 10
Dependent Claim
41 words
A valve equivalent comprising a plurality of molded valve leaflets connected to a base, wherein the molded valve leaflets comprise a molded biopolymer having fibrils and cells within the molded biopolymer, wherein the fibrils of the molded biopolymer have commisure-to-commisure alignment.
Claim 11
Dependent Claim
23 words
The valve equivalent of claim 8 , wherein the valve equivalent has 2, 3, or 4 molded valve leaflets connected to the base.
Claim 12
Dependent Claim
12 words
The valve equivalent of claim 8 , wherein the biopolymer is cross-linked.
Claim 13
Dependent Claim
33 words
The valve equivalent of claim 10 , wherein a stress-strain curve obtained using at least one of the molded valve leaflets is similar to a stress-strain curve obtained using a native valve leaflet.
Claim 14
Dependent Claim
14 words
The valve equivalent of claim 8 , wherein the biopolymer is a fibrillar biopolymer.
Claim 15
Dependent Claim
15 words
The valve equivalent of claim 12 , wherein the fibrillar biopolymer is collagen or fibrin.
Claim 16
Dependent Claim
14 words
The valve equivalent of claim 8 , wherein the cells are fibroblasts or myofibroblasts.
Claim 17
Dependent Claim
21 words
The valve equivalent of claim 8 , wherein the valve equivalent is a heart valve equivalent or a venous valve replacement.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-12-22 | 2007-06-23 | 2007-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-12-22 | 2011-06-23 | 2011-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-12-22 | 2015-06-23 | 2015-12-23 | $7700.00 | Window Closed / Lapsed |