US6284305B1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug coating with topcoat
Assignee: Boston Scientific Scimed Inc
•
Filing: 2000-05-18
•
Granted: 2001-09-04
•
Expires: 2020-05-18
Abstract
Abstract A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.
Inventors
- 👤 Ni Ding
- 👤 Michael N. Helmus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:40
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/141; A61L31/16; A61F2210/00; A61F2210/0014; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/416; A61L2300/42; A61L2300/60; A61L2300/602; A61L2300/606; A61L2300/608; A61L2420/00; A61L2420/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
100 words
A method of coating an implantable stent prosthesis having at least a portion which is implantable into the body of a patient, wherein at least a part of the stent portion is covered with a coating for release of at least one biologically active material; the method comprising: (a) applying an undercoat comprising a polymeric material and the biologically active material to the stent portion wherein the undercoat has a surface; and (b) applying a discontinuous topcoat which covers less than the entire surface of the undercoat, said topcoat comprising a polymeric material, substantially free of pores and pore-forming materials.
Claim 2
Independent Claim
100 words
A method of coating an implantable stent prosthesis having at least a portion which is implantable into the body of a patient, wherein at least a part of the stent portion is covered with a coating for release of at least one biologically active material; the method comprising: (a) applying an undercoat comprising a polymeric material and the biologically active material to the stent portion wherein the undercoat has a surface; and (b) applying a discontinuous topcoat which covers less than the entire surface of the undercoat, said topcoat comprising a polymeric material, substantially free of pores and pore-forming materials.
Claim 3
Dependent Claim
48 words
The method of claim 1 wherein the polymeric material of the undercoat is a hydrophobic elastomeric material and wherein the polymeric material of the undercoat is a biostable, biocompatible material which provides long term non-thrombogenicity to the stent portion during and after release of the biologically active material.
Claim 4
Dependent Claim
28 words
The method of claim 1 wherein the polymeric material of the topcoat is selected from the group consisting of fluorosilicone, polyethylene glycol (PEG), polysaccharides, phospholipids and combinations thereof.
Claim 5
Dependent Claim
20 words
The method of claim 1 wherein the topcoat covers from about 5% to 95% of the surface of the undercoat.
Claim 6
Dependent Claim
20 words
The method of claim 4 wherein the topcoat covers from about 20% to 85% of the surface of the undercoat.
Claim 7
Dependent Claim
23 words
The method of claim 1 wherein the topcoat has an average thickness of about the average particle size of the biologically active material.
Claim 8
Dependent Claim
18 words
The method of claim 1 wherein the topcoat has an average thickness of about 1 to 7 microns.
Claim 9
Dependent Claim
18 words
The method of claim 7 wherein the topcoat has an average thickness of about 1 to 5 microns.
Claim 10
Dependent Claim
32 words
The method of claim 1 wherein the polymeric material of the topcoat is a polymer which is incompatible with the polymeric material of the undercoat such that the discontinuous topcoat is formed.
Claim 11
Dependent Claim
25 words
The method of claim 1 which further comprises applying a poor solvent to the topcoat to shrink the polymeric material to form the discontinuous topcoat.
Claim 12
Dependent Claim
29 words
The method of claim 1 wherein the Young's modulus of the polymeric material of the undercoat and the Young's modulus of the polymeric material of the topcoat are different.
Claim 13
Dependent Claim
29 words
The method of claim 11 wherein the Young's modulus of the polymeric material of the topcoat is greater than the Young's modulus of the polymeric material of the undercoat.
References Cited (Backward Citations)
US3932627A
Cited
US4292965A
Cited
US4613665A
Cited
US4655771B1
Cited
US4655771A
Cited
US4954126A
Cited
US4954126B1
Cited
US4872867A
Cited
US5061275A
Cited
US4886062A
Cited
US4916193A
Cited
US5185408A
Cited
US5318779A
Cited
US5019096A
Cited
US5182317A
Cited
US5338770A
Cited
US5262451A
Cited
US5749915A
Cited
US5226913A
Cited
US5092877A
Cited
US5292802A
Cited
US5308889A
Cited
US4994071A
Cited
US5415619A
Cited
US5545208A
Cited
WO1991012779A1
Cited
US5447724A
Cited
US5258020A
Cited
US5163952A
Cited
US5180366A
Cited
US5304121A
Cited
WO1992015286A1
Cited
US5356433A
Cited
US5429618A
Cited
US5449382A
Cited
US5342348A
Cited
US5419760A
Cited
WO1994021308A1
Cited
WO1994021309A1
Cited
US5624411A
Cited
US5464650A
Cited
EP0623354A1
Cited
US5716981A
Cited
US5380299A
Cited
US5543155A
Cited
WO1996000272A1
Cited
US5637113A
Cited
EP0734721A2
Cited
US5980972A
Cited
US6042875A
Cited
US6110483A
Cited
US6198016B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-09-03 | 2005-03-05 | 2005-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-09-03 | 2009-03-05 | 2009-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-09-03 | 2013-03-05 | 2013-09-04 | $7700.00 | Window Closed / Lapsed |